Brand-Name Drugs Starting With O
The month or window each one is expected to get its first, lower-cost generic. Each drug opens its own launch page with the patents, approvals and prices behind its month.
This list is aggregated from FDA records, court filings and company announcements. Coded and designed by Dr. Brian Staiger, PharmD, BCPS
Updated October 9, 2026 How we build our data
O
- Ocaliva Obeticholic Acid No date yet
- Odefsey Emtricitabine, Rilpivirine Hydrochloride, and Tenofovir Alafenamide Fumarate January 2032
- Odomzo Sonidegib Phosphate March 2036
- Ogsiveo Nirogacestat 2037 to 2038
- Ohtuvayre Ensifentrine June 2038
- Ojemda Tovorafenib August 2036
- Ojjaara Momelotinib December 2040
- Oleptro Trazodone Hydrochloride No date yet
- Olinvyk Oliceridine October 2034
- Olpruva Sodium Phenylbutyrate No date yet
- Olumiant Baricitinib Jan to Jun 2032
- Olysio Simeprevir Sodium July 2027
- Omeprazole Omeprazole December 2036
- Omidria Ketorolac Tromethamine and Phenylephrine Hydrochloride April 2032
- Omlonti Omidenepag Isopropyl January 2035
- Omnaris Ciclesonide No date yet
- Onapgo Apomorphine Hydrochloride February 2032
- Ongentys Opicapone December 2032
- Onivyde Irinotecan October 2036
- Onpattro Patisiran Sodium August 2035
- Onsolis Fentanyl Citrate No date yet
- Onureg Azacitidine 2027 to 2028
- Onyda XR Clonidine Hydrochloride July 2041
- Onzetra Xsail Sumatriptan October 2034
- Opfolda Miglustat August 2037
- Opsynvi Macitentan and Tadalafil September 2031
- Opvee Nalmefene Hydrochloride No date yet
- Opzelura Ruxolitinib Phosphate 2034 to 2035
- Orbactiv Oritavancin Diphosphate August 2029
- Orenitram Treprostinil Diolamine June 2027
- Orfadin Nitisinone February 2033
- Orgovyx Relugolix 2034 to 2035
- Oriahnn Elagolix, Estradiol, and Norethindrone Acetate 2035 to 2036
- Orilissa Elagolix Sodium 2034 to 2036
- Orkambi Ivacaftor and Lumacaftor June 2031
- Orladeyo Berotralstat Hydrochloride October 2035
- Orlynvah Probenecid and Sulopenem Etzadroxil April 2039
- Orserdu Elacestrant Hydrochloride 2035 to 2037
- Ortikos Budesonide September 2036
- Orzeyful Oveporexton August 2040
- Osmolex ER Amantadine Hydrochloride February 2038
- Osmoprep Sodium Phosphate, Dibasic, Anhydrous and Sodium Phosphate, Monobasic, Monohydrate No date yet
- Osphena Ospemifene 2026 to 2027
- Otezla Apremilast August 2028
- Otezla XR Apremilast 2031 to 2032
- Otiprio Ciprofloxacin November 2038
- Otrexup Methotrexate May 2031
- Oxaydo Oxycodone Hydrochloride No date yet
- Oxbryta Voxelotor January 2034
- Oxlumo Lumasiran 2038 to 2039
- Ozempic Semaglutide 2031 to 2032
See every expected first generic month by month on Generic Launches. Not seeing yours? Ask a pharmacist and we will look it up.