Drug & supplement interaction

7,8-benzoflavone + Methenamine Hippurate

Methenamine Hippurate brand names: Urex, Hiprex.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 7,8-benzoflavone and Methenamine Hippurate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

7,8-benzoflavone and Methenamine Hippurate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methenamine Hippurate and 7,8-benzoflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for 7,8-benzoflavone at all — not against Methenamine Hippurate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7,8-benzoflavone safety at a glance

7,8-benzoflavone overall Avoid Human safety data are lacking and it is mainly a research chemical, not a tested supplement.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibit... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibit... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methenamine Hippurate and 7,8-benzoflavone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Methenamine Hippurate’s Own FDA Label Lists

This is not an interaction — none of it involves 7,8-benzoflavone. These are the most notable effects listed in the ADVERSE REACTIONS section of Methenamine Hippurate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Itching
  • Nausea mentioned in 6.6% of FDA reports for Methenamine Hippurate
  • A skin rash
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Methenamine Hippurate. Read the label on DailyMed › Where a percentage is shown, it is the share of 1,210 voluntary FDA FAERS reports for Methenamine Hippurate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. 7,8-benzoflavone’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no 7,8-benzoflavone side to compare — that is a limit of the record, not a statement that 7,8-benzoflavone has no side effects.

Special populations

7,8-benzoflavone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibitors are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methenamine Hippurate

This page covers 7,8-benzoflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methenamine Hippurate page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate) and Bifidobacterium Bifidum (moderate).

By severity: 1 major · 33 moderate · 10 minor.

From our pharmacist’s overview on the Methenamine Hippurate page

“Most people taking methenamine hippurate (Hiprex, Urex) use it daily to prevent repeat urinary tract infections, and many also take probiotics, which is where the bulk of this 44-ingredient list sits. Even so, the page deserves real vigilance, because one entry is rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Methenamine Hippurate interaction page

How much people look this up

Where 7,8-benzoflavone and Methenamine Hippurate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7,8-benzoflavone
Steady interest

#1,093 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methenamine Hippurate
Steady interest

#1,825 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7,8-benzoflavone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 7,8-benzoflavone and Methenamine Hippurate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7,8-benzoflavone

What is 7,8-benzoflavone?

  • Lowering estrogen levels
  • Raising testosterone
  • Reducing gynecomastia from anabolic steroids
  • Bodybuilding and athletic performance

7,8-Benzoflavone (alpha-naphthoflavone) is a synthetic flavone studied mainly in laboratories for its effects on enzymes like aromatase and certain liver enzymes. It is not an approved or well-studied dietary supplement in humans, its safety is poorly defined, and aromatase inhibitors are banned in sports — so it should not be used without medical supervision.

Synthetic flavone compound (also studied as a plant flavonoid derivative) · Research chemical; sometimes found in bodybuilding or 'aromatase inhibitor' supplements

An interaction check asks whether these two react with each other — it does not ask whether 7,8-benzoflavone is a good idea for someone in your situation. Here is what our 7,8-benzoflavone record says about it on its own.

7,8-benzoflavone: dosing

There is no established or safe human dose for 7,8-benzoflavone. It is not an approved supplement or medicine, and reliable dosing information does not exist.We do not recommend taking it.

From our 7,8-benzoflavone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7,8-benzoflavone monograph & all interactions
Medication

About Methenamine

What Is Methenamine Used For?

Brand names: Urex, Hiprex

Methenamine is used to suppress or prevent frequently recurring urinary tract infections (UTIs), including pyelonephritis (kidney infection) and cystitis (bladder infection). It is intended for long-term or ongoing use after another antibiotic has already cleared the active infection — not as a first treatment for a new, acute infection.

Methenamine Mandelate (available as an oral solution and tablet) is also indicated for infected residual urine that can occur with certain neurologic diseases. It is not appropriate as the sole treatment when an infection is causing systemic symptoms like chills and fever.

Most-Reported Side Effects for Methenamine Hippurate

From FAERS, the FDA’s public side-effect reporting system (1,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Urinary tract infection 163 reports
Diarrhea 81 reports
Nausea 80 reports
Fall 74 reports
Fatigue 74 reports
See full Methenamine drug information
Keep checking

Other Drugs & 7,8-benzoflavone

Browse every other medication we’ve checked against 7,8-benzoflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked 7,8-benzoflavone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7,8-benzoflavone list.

See the full 7,8-benzoflavone interactions page
See every supplement checked against Methenamine Hippurate, ranked by severity
Evidence & sources

7,8-benzoflavone References

The 1 references that drive our 7,8-benzoflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7,8-benzoflavone and Methenamine Hippurate Together: Common Questions

Is it safe to take 7,8-benzoflavone with Methenamine Hippurate?
We do not list a known interaction between 7,8-benzoflavone and Methenamine Hippurate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Methenamine Hippurate interact with any supplements?
Yes. Methenamine Hippurate has documented interactions with 44 supplements in our database — 7,8-benzoflavone is not one of them. The Methenamine Hippurate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7,8-benzoflavone monograph Uses, safety profile, and every drug interaction in one place Methenamine drug information The full plain-English guide to this medication Methenamine Hippurate supplement interactions Every supplement checked against Methenamine Hippurate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methenamine Hippurate and 7,8-benzoflavone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.