Drug & supplement interaction

Abuta + Relugolix, Estradiol, Norethindrone Acetate

Relugolix, Estradiol, Norethindrone Acetate brand name: Myfembree.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Abuta and Relugolix, Estradiol, Norethindrone Acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Abuta and Relugolix, Estradiol, Norethindrone Acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Relugolix, Estradiol, Norethindrone Acetate and Abuta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Abuta safety at a glance

Abuta overall Use caution Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Avoid Traditionally used to affect the uterus and childbirth; avoid during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Relugolix, Estradiol, Norethindrone Acetate and Abuta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Relugolix, Estradiol, Norethindrone Acetate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Relugolix, Estradiol, Norethindrone Acetate is filed under 12 classifications — including progestin, ethinyl estradiol, estrogens. Abuta has documented interactions with 1 drug class — the most serious being diuretic drugs (moderate) — and none of Relugolix, Estradiol, Norethindrone Acetate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Abuta Does Interact With Other Medications

Abuta has 75 moderate known drug interactions in our database — Relugolix, Estradiol, Norethindrone Acetate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 75 No known interaction 2,755 (incl. Relugolix, Estradiol, Norethindrone Acetate)
Taking anything else?

Check Another of Your Medications Against Abuta

Covers the 2,830 medications we’ve checked against Abuta. Pick one to open its full report.

What to actually watch for

What Relugolix, Estradiol, Norethindrone Acetate’s Own FDA Label Lists

This is not an interaction — none of it involves Abuta. These are the most notable effects listed in the ADVERSE REACTIONS section of Relugolix, Estradiol, Norethindrone Acetate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • Bone thinning Worth acting on
  • Low mood Worth acting on
  • Raised blood pressure Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on
  • Bleeding or bruising Worth acting on
  • An allergic reaction Worth acting on
  • Changes to your period
  • A change in sex drive

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Relugolix, Estradiol, Norethindrone Acetate. Read the label on DailyMed › Abuta’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Abuta side to compare — that is a limit of the record, not a statement that Abuta has no side effects.

Everything else you take

See Every Supplement That Interacts With Relugolix, Estradiol, Norethindrone Acetate

This page covers Abuta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Relugolix, Estradiol, Norethindrone Acetate page lists 219 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 174 moderate · 37 minor.

From our pharmacist’s overview on the Relugolix, Estradiol, Norethindrone Acetate page

“Grapefruit is where I would start on this page. Myfembree (relugolix, estradiol, and norethindrone acetate) depends on the CYP3A4 enzyme to be cleared, and grapefruit juice blocks that enzyme, raising drug levels and side effect risk.”

Reviewed by 2 · Jul 18, 2026

Open the Relugolix, Estradiol, Norethindrone Acetate interaction page

One more smart check

Taking Abuta as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Abuta, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Abuta. Even though Abuta itself has no known interaction with Relugolix, Estradiol, Norethindrone Acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Abuta and Relugolix, Estradiol, Norethindrone Acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Abuta
Top half

#723 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Relugolix, Estradiol, Norethindrone Acetate
Steady interest

#2,053 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Abuta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Abuta and Relugolix, Estradiol, Norethindrone Acetate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Abuta

What is Abuta?

Abuta
  • Menstrual cramps and women's health
  • Kidney and urinary tract complaints
  • Digestive upset
  • Fever
  • Traditional support during pregnancy and childbirth

Abuta (Cissampelos pareira) is a tropical climbing plant used in traditional medicine, especially for menstrual and urinary complaints. Good-quality human studies are lacking, so its benefits and safety are not well established. Because of uncertain safety—and its traditional use to affect the uterus—it should be avoided during pregnancy and breastfeeding and discussed with a pharmacist or doctor first.

Cissampelos pareira · Menispermaceae · Root (most common), with bark, seeds, and above-ground parts also used · Dried root, tea/decoction, tincture, capsules, powder

An interaction check asks whether these two react with each other — it does not ask whether Abuta is a good idea for someone in your situation. Here is what our Abuta record says about it on its own.

Abuta: dosing

There is no established, standardized dose of abuta. Traditional preparations vary, and modern supplements come in different strengths and forms, so there is no single recommended amount that has been proven safe and effective.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Abuta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Abuta monograph & all interactions
Medication

About Relugolix, Estradiol, and Norethindrone

What Is Relugolix, Estradiol, and Norethindrone Used For?

Brand name: Myfembree

Myfembree is approved for two conditions in premenopausal women: managing heavy menstrual bleeding caused by uterine fibroids (non-cancerous growths in the uterus), and managing moderate to severe pain caused by endometriosis (a condition where tissue similar to the uterine lining grows outside the uterus).

Treatment with Myfembree should not exceed 24 months because of the risk of ongoing bone loss that may not fully reverse after stopping the medication.

See full Relugolix, Estradiol, and Norethindrone drug information
Keep checking

Other Drugs & Abuta

Browse every other medication we’ve checked against Abuta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
75Moderate
0Minor
2,754No known interaction
75 Moderate 2,754 No interaction
Moderate

75 interactions

Showing 60 of 75 moderate interactions — see all 75 on the Abuta page.

No interaction 2,754 drugs checked — show the list

We also checked Abuta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,754 medications checked with no known interaction — see the full Abuta list.

See the full Abuta interactions page
See every supplement checked against Relugolix, Estradiol, Norethindrone Acetate, ranked by severity
Evidence & sources

Abuta References

The 1 references that drive our Abuta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sayana SB, Khanwelkar CC, Nimmagadda VR, et al. Evaluation of diuretic activity of alcoholic extract of roots of cissampelos pareira in albino rats. J Clin Diagn Res. 2014;8(5):HC01-4.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Abuta and Relugolix, Estradiol, Norethindrone Acetate Together: Common Questions

Is it safe to take Abuta with Relugolix, Estradiol, Norethindrone Acetate?
We do not list a known interaction between Abuta and Relugolix, Estradiol, Norethindrone Acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Abuta and Relugolix, Estradiol, Norethindrone Acetate combination checked?
Interactions in our licensed database are recorded against drug classes. Relugolix, Estradiol, Norethindrone Acetate is filed under 12 classifications, and Abuta has documented interactions with 1 drug class — none of Relugolix, Estradiol, Norethindrone Acetate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Abuta interact with any other medications?
Yes. Abuta has 75 documented drug interactions in our database — Relugolix, Estradiol, Norethindrone Acetate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Relugolix, Estradiol, Norethindrone Acetate interact with any supplements?
Yes. Relugolix, Estradiol, Norethindrone Acetate has documented interactions with 219 supplements in our database — Abuta is not one of them. The Relugolix, Estradiol, Norethindrone Acetate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Abuta monograph Uses, safety profile, and every drug interaction in one place Relugolix, Estradiol, and Norethindrone drug information The full plain-English guide to this medication Relugolix, Estradiol, Norethindrone Acetate supplement interactions Every supplement checked against Relugolix, Estradiol, Norethindrone Acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Relugolix, Estradiol, Norethindrone Acetate and Abuta?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.