Drug & supplement interaction

Active Hexose Correlated Compound (ahcc) + Ethinyl Estradiol, Norethindrone

Ethinyl Estradiol, Norethindrone brand names: Femhrt, Loestrin 21, Ovcon 35 21, Ovcon 50 28, Necon 0.5 35 21, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ethinyl Estradiol, Norethindrone states a food rule worth keeping to.

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Interaction report

Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ethinyl Estradiol, Norethindrone and Active Hexose Correlated Compound (ahcc) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Active Hexose Correlated Compound (ahcc) safety at a glance

Active Hexose Corr... overall Use caution Generally well tolerated in short-term studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ethinyl Estradiol, Norethindrone and Active Hexose Correlated Compound (ahcc)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ethinyl Estradiol, Norethindrone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ethinyl Estradiol, Norethindrone is filed under 13 classifications — including progestin, contraceptive drugs, estrogens. Active Hexose Correlated Compound (ahcc) has documented interactions with 2 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate) and immunosuppressants (moderate) — and none of Ethinyl Estradiol, Norethindrone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Active Hexose Correlated Compound (ahcc) Does Interact With Other Medications

Active Hexose Correlated Compound (ahcc) has 312 moderate known drug interactions in our database — Ethinyl Estradiol, Norethindrone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 312 No known interaction 2,518 (incl. Ethinyl Estradiol, Norethindrone)
Taking anything else?

Check Another of Your Medications Against Active Hexose Correlated Compound (ahcc)

Covers the 2,830 medications we’ve checked against Active Hexose Correlated Compound (ahcc). Pick one to open its full report.

What to actually watch for

What Ethinyl Estradiol, Norethindrone’s Own FDA Label Lists

This is not an interaction — none of it involves Active Hexose Correlated Compound (ahcc). These are the most notable effects listed in the ADVERSE REACTIONS section of Ethinyl Estradiol, Norethindrone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Raised blood pressure Worth acting on
  • Bleeding or bruising Worth acting on

From the ADVERSE REACTIONS section of the FDA label for Ethinyl Estradiol, Norethindrone. Read the label on DailyMed › Active Hexose Correlated Compound (ahcc)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Active Hexose Correlated Compound (ahcc) side to compare — that is a limit of the record, not a statement that Active Hexose Correlated Compound (ahcc) has no side effects.

How to take them

Some Ethinyl Estradiol, Norethindrone Products Have a Food Rule — Active Hexose Correlated Compound (ahcc) Should Not Break It

At least one FDA label for a product containing Ethinyl Estradiol, Norethindrone says to take it with food. If you take Active Hexose Correlated Compound (ahcc) on an empty stomach out of habit, keep them separate — and take Ethinyl Estradiol, Norethindrone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ethinyl Estradiol, Norethindrone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Tablets should be taken regularly with a meal or at bedtime.

From the Dosage and Administration section of the FDA label we read for Ethinyl Estradiol, Norethindrone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ethinyl Estradiol, Norethindrone

This page covers Active Hexose Correlated Compound (ahcc) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethinyl Estradiol, Norethindrone page lists 240 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 196 moderate · 38 minor.

From our pharmacist’s overview on the Ethinyl Estradiol, Norethindrone page

“If you take a birth control pill or hormone therapy containing ethinyl estradiol and norethindrone (Loestrin, Femhrt, and others), a few supplements can genuinely undermine it, so read this page with care. Six of the 240 ingredients on file are rated major, and those six come first.”

Reviewed by 2 · Jul 18, 2026

Open the Ethinyl Estradiol, Norethindrone interaction page

How much people look this up

Where Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Active Hexose Correlated Compound (ahcc)
Steady interest

#1,051 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethinyl Estradiol, Norethindrone
Top 10%

#258 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Active Hexose Correlated Compound (ahcc) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Active Hexose Correlated Compound (ahcc)

What is Active Hexose Correlated Compound (ahcc)?

Active Hexose Correlated Compound (ahcc)
  • Immune support
  • Supporting people during chemotherapy
  • General wellness
  • Liver health
  • HPV-related concerns

AHCC is a proprietary mushroom-derived supplement promoted mainly for immune support and to help people tolerate cancer treatment. Early human studies are interesting but small, and the overall evidence is limited and not conclusive for any condition. Talk with your pharmacist or doctor before using it, especially if you have a health condition or take medications.

Cultured mycelia of basidiomycete mushrooms (including shiitake, Lentinula edodes) · Capsules, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Active Hexose Correlated Compound (ahcc) is a good idea for someone in your situation. Here is what our Active Hexose Correlated Compound (ahcc) record says about it on its own.

Active Hexose Correlated Compound (ahcc): dosing

There is no official standardized dose of AHCC, and the amount used has varied across studies.

From our Active Hexose Correlated Compound (ahcc) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Active Hexose Correlated Compound (ahcc) monograph & all interactions
Keep checking

Other Drugs & Active Hexose Correlated Compound (ahcc)

Browse every other medication we’ve checked against Active Hexose Correlated Compound (ahcc) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
312Moderate
0Minor
2,517No known interaction
312 Moderate 2,517 No interaction
Moderate

312 interactions

Showing 60 of 312 moderate interactions — see all 312 on the Active Hexose Correlated Compound (ahcc) page.

No interaction 2,517 drugs checked — show the list

We also checked Active Hexose Correlated Compound (ahcc) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,517 medications checked with no known interaction — see the full Active Hexose Correlated Compound (ahcc) list.

See the full Active Hexose Correlated Compound (ahcc) interactions page
See every supplement checked against Ethinyl Estradiol, Norethindrone, ranked by severity
Evidence & sources

Active Hexose Correlated Compound (ahcc) References

The 16 references that drive our Active Hexose Correlated Compound (ahcc) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  2. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  3. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
  4. Aviles, H., O'Donnell, P., Sun, B., and Sonnenfeld, G. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg.Infect.(Larchmt.) 2006;7(6):527-535. PubMed
  5. Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. PubMed
  6. Ritz, B. W. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Nutr.Rev. 2008;66(9):526-531. PubMed
  7. Terakawa, N., Matsui, Y., Satoi, S., Yanagimoto, H., Takahashi, K., Yamamoto, T., Yamao, J., Takai, S., Kwon, A. H., and Kamiyama, Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controll
  8. Mach, C. M., Fugii, H., Wakame, K., and Smith, J. Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr.Oncol. 2008;6(3):105-109.
  9. Wang, S., Welte, T., Fang, H., Chang, G. J., Born, W. K., O'Brien, R. L., Sun, B., Fujii, H., Kosuna, K., and Wang, T. Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. J Nutr. 2009;139(3 PubMed
  10. Yin, Z., Fujii, H., and Walshe, T. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hum.Immunol. 2010;71(12):1187-1190.
  11. Lee, W. W., Lee, N., Fujii, H., and Kang, I. Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1beta production from monocytes in humans. Cell Immunol. 2012;275(1-2):19-23.
  12. Daddaoua, A., Martinez-Plata, E., Ortega-Gonzalez, M., Ocon, B., Aranda, C. J., Zarzuelo, A., Suarez, M. D., de Medina, F. S., and Martinez-Augustin, O. The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actio
  13. Roman, B. E., Beli, E., Duriancik, D. M., and Gardner, E. M. Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. 2013;33(1):12-17. PubMed
  14. Uno, K., Kosuna, K., Sun, B., Fujii, H., Wakame, K., Chikumaru, S., Hosokawa, G., and Ueda, Y. Active Hexose Correlated Compound (AHCC) Improves Immunological Parameters and Performance Status of Patients with Solid Tumors. Biotherapy 2000;14(3):303-309.
  15. Ghoneum, M., Wimbley, M., Salem, F., McKlain, A., Attallah, N., and Gill, G. Immunomodulatory and anticancer effects of active hexose correlated compound (AHCC). Int J Immunother 1995;11:23-28.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone Together: Common Questions

Is it safe to take Active Hexose Correlated Compound (ahcc) with Ethinyl Estradiol, Norethindrone?
We do not list a known interaction between Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone at the same time of day?
At least one FDA label for a product containing Ethinyl Estradiol, Norethindrone says to take it with food. If you take Active Hexose Correlated Compound (ahcc) on an empty stomach out of habit, keep them separate and take Ethinyl Estradiol, Norethindrone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ethinyl Estradiol, Norethindrone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Active Hexose Correlated Compound (ahcc) and Ethinyl Estradiol, Norethindrone combination checked?
Interactions in our licensed database are recorded against drug classes. Ethinyl Estradiol, Norethindrone is filed under 13 classifications, and Active Hexose Correlated Compound (ahcc) has documented interactions with 2 drug classes — none of Ethinyl Estradiol, Norethindrone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Active Hexose Correlated Compound (ahcc) interact with any other medications?
Yes. Active Hexose Correlated Compound (ahcc) has 312 documented drug interactions in our database — Ethinyl Estradiol, Norethindrone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ethinyl Estradiol, Norethindrone interact with any supplements?
Yes. Ethinyl Estradiol, Norethindrone has documented interactions with 240 supplements in our database — Active Hexose Correlated Compound (ahcc) is not one of them. The Ethinyl Estradiol, Norethindrone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Active Hexose Correlated Compound (ahcc) monograph Uses, safety profile, and every drug interaction in one place Ethinyl Estradiol, Norethindrone supplement interactions Every supplement checked against Ethinyl Estradiol, Norethindrone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ethinyl Estradiol, Norethindrone and Active Hexose Correlated Compound (ahcc)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.