Drug & supplement interaction

Akkermansia + Interferon Beta-1a

Interferon Beta-1a brand names: Rebif, Avonex.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Akkermansia and Interferon Beta-1a in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Akkermansia and Interferon Beta-1a

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Interferon Beta-1a and Akkermansia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Akkermansia at all — not against Interferon Beta-1a, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Akkermansia safety at a glance

Akkermansia overall Use caution Small human studies suggest short-term use is generally well tolerated, but long-term safety data are limited.

Pregnancy Avoid There is not enough safety information, so it is best to avoid during pregnancy.

Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Interferon Beta-1a and Akkermansia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Everything else you take

See Every Supplement That Interacts With Interferon Beta-1a

This page covers Akkermansia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Beta-1a page lists 57 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 3 major · 53 moderate · 1 minor.

From our pharmacist’s overview on the Interferon Beta-1a page

“Siberian cocklebur, an herb tied to documented cases of liver failure, is the first name to know for anyone injecting interferon beta-1a (Rebif, Avonex) for multiple sclerosis. Interferon beta-1a can strain the liver on its own, which is why prescribers order routine liver blood tests, and 38 of the 57 supplements on file carry that sa…”

Reviewed by 2 · Jul 18, 2026

Open the Interferon Beta-1a interaction page

How much people look this up

Where Akkermansia and Interferon Beta-1a Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Akkermansia

Steady interest

#728 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Interferon Beta-1a

Steady interest

#2,614 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Akkermansia is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Akkermansia reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Akkermansia and Interferon Beta-1a records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Akkermansia

What is Akkermansia?

Gut health support
Metabolic health and blood sugar
Weight management
Gut lining (barrier) support

Akkermansia muciniphila is a gut bacterium sold as a next-generation probiotic. Early research in animals and small human studies looks promising for metabolic and gut health, but the evidence is still limited and long-term safety is not fully known. Talk with your pharmacist or doctor before trying it, especially if you have a weakened immune system.

Akkermansia muciniphila · Akkermansiaceae · Whole bacterial cells (live or pasteurized) · Capsules, powders (probiotic supplements)

An interaction check asks whether these two react with each other — it does not ask whether Akkermansia is a good idea for someone in your situation. Here is what our Akkermansia record says about it on its own.

Akkermansia: dosing

There is no official, standardized dose for Akkermansia muciniphila. Doses are usually measured in colony-forming units (CFU) or by the amount of bacterial cells, and these vary from product to product.The best approach is to follow the directions on the product label and not take more than recommended. If you notice ongoing digestive problems, stop and get medical advice.

From our Akkermansia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Akkermansia monograph & all interactions

Medication

About Interferon Beta-1a Intramuscular Injection

What Is Interferon Beta-1a Intramuscular Injection Used For?

Brand names: Rebif, Avonex

Interferon beta-1a intramuscular injection is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:
- clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),
- relapsing-remitting forms (course of disease where symptoms flare up from time to time), or
- secondary progressive forms (course of disease where relapses occur more often).
Interferon beta-1a is in a class of medications called immunomodulators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.

Most-Reported Side Effects for Interferon Beta-1a

From FAERS, the FDA’s public side-effect reporting system (192,069 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Multiple sclerosis relapse 15,851 reports

Influenza like illness 13,253 reports

Fatigue 11,554 reports

Fall 10,604 reports

Multiple sclerosis 9,358 reports

See full Interferon Beta-1a Intramuscular Injection drug information

Keep checking

Other Drugs & Akkermansia

Browse every other medication we’ve checked against Akkermansia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Akkermansia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Akkermansia list.

See the full Akkermansia interactions page

See every supplement checked against Interferon Beta-1a, ranked by severity

Evidence & sources

Akkermansia References

The 2 sources that drive our Akkermansia monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Akkermansia is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Probiotics: What You Need To Know — NIH NCCIH Source
Probiotics — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Akkermansia and Interferon Beta-1a Together: Common Questions

Is it safe to take Akkermansia with Interferon Beta-1a?

We do not list a known interaction between Akkermansia and Interferon Beta-1a. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Interferon Beta-1a interact with any supplements?

Yes. Interferon Beta-1a has documented interactions with 57 supplements in our database — Akkermansia is not one of them. The Interferon Beta-1a interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Akkermansia monograph Uses, safety profile, and every drug interaction in one place Interferon Beta-1a Intramuscular Injection drug information The full plain-English guide to this medication Interferon Beta-1a supplement interactions Every supplement checked against Interferon Beta-1a, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Interferon Beta-1a and Akkermansia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.