Drug & supplement interaction

Albizia Julibrissin + Protriptyline

Protriptyline brand name: Vivactil.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Albizia Julibrissin and Protriptyline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Albizia Julibrissin and Protriptyline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Protriptyline and Albizia Julibrissin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Albizia Julibrissin safety at a glance

Albizia Julibrissi... overall Use caution Limited human safety data, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; traditionally avoided in pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Protriptyline and Albizia Julibrissin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Protriptyline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Protriptyline is filed under 7 classifications — including tricyclic antidepressants (tcas), antidepressant drugs, serotonergic drugs. Albizia Julibrissin has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Protriptyline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Albizia Julibrissin Does Interact With Other Medications

Albizia Julibrissin has 248 moderate known drug interactions in our database — Protriptyline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Protriptyline)
Taking anything else?

Check Another of Your Medications Against Albizia Julibrissin

Covers the 2,830 medications we’ve checked against Albizia Julibrissin. Pick one to open its full report.

What to actually watch for

What Protriptyline’s Own FDA Label Lists

This is not an interaction — none of it involves Albizia Julibrissin. These are the most notable effects listed in the ADVERSE REACTIONS section of Protriptyline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Dependence or withdrawal symptoms Worth acting on
  • A bowel blockage Worth acting on
  • Trouble passing urine Worth acting on
  • Unsteadiness Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on

Showing the 10 most notable of 49 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Protriptyline. Read the label on DailyMed › Albizia Julibrissin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Albizia Julibrissin side to compare — that is a limit of the record, not a statement that Albizia Julibrissin has no side effects.

From our Q&A

Questions About Albizia Julibrissin or Protriptyline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Albizia Julibrissin or Protriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Protriptyline

This page covers Albizia Julibrissin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Protriptyline page lists 93 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Lithium (major), Scopolia (major) and 5-htp (moderate).

By severity: 4 major · 71 moderate · 18 minor.

From our pharmacist’s overview on the Protriptyline page

“Protriptyline (Vivactil) is an older tricyclic antidepressant, and I read its supplement list with genuine care because so much of it piles onto what the drug already does. Four of the 93 ingredients on file rate major, and those deserve your attention before anything else.”

Reviewed by 2 · Jul 18, 2026

Open the Protriptyline interaction page

One more smart check

Taking Albizia Julibrissin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 124 real supplement products containing Albizia Julibrissin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Albizia Julibrissin. Even though Albizia Julibrissin itself has no known interaction with Protriptyline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Albizia Julibrissin and Protriptyline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Albizia Julibrissin
Top half

#659 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Protriptyline
Top half

#786 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Albizia Julibrissin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Albizia Julibrissin and Protriptyline records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Albizia Julibrissin

What is Albizia Julibrissin?

Albizia Julibrissin
  • Anxiety and stress
  • Low mood or mild depression
  • Sleep trouble (insomnia)
  • Irritability
  • Traditional support for swelling or injuries

Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming the mind, lifting mood, and easing sleep problems. Human evidence is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Albizia julibrissin · Fabaceae · Flower (He Huan Hua) and stem bark (He Huan Pi) · Dried flowers or bark, teas, decoctions, tinctures, capsules, and powders

An interaction check asks whether these two react with each other — it does not ask whether Albizia Julibrissin is a good idea for someone in your situation. Here is what our Albizia Julibrissin record says about it on its own.

Albizia Julibrissin: dosing

There is no well-established or standardized dose for Albizia julibrissin. Traditional preparations use the dried flower or bark in teas and decoctions, but the strength of commercial products varies widely.If you choose to try it, follow the directions on the product label and do not exceed the suggested amount. A pharmacist can help you review the product and decide whether it is appropriate for you. Starting low and watching how you feel is a sensible approach with any new supplement.

From our Albizia Julibrissin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Albizia Julibrissin monograph & all interactions
Medication

About Protriptyline

What Is Protriptyline Used For?

Brand name: Vivactil

Protriptyline Hydrochloride tablets are used to treat symptoms of mental depression in patients who are under close medical supervision. Because it has activating (energizing) properties rather than sedating ones, it may be especially useful for people with depression who feel withdrawn or have very low energy.

See full Protriptyline drug information
Keep checking

Other Drugs & Albizia Julibrissin

Browse every other medication we’ve checked against Albizia Julibrissin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Albizia Julibrissin page.

No interaction 2,581 drugs checked — show the list

We also checked Albizia Julibrissin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Albizia Julibrissin list.

See the full Albizia Julibrissin interactions page
See every supplement checked against Protriptyline, ranked by severity
Evidence & sources

Albizia Julibrissin References

The 1 references that drive our Albizia Julibrissin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kang, T. H., Jeong, S. J., Kim, N. Y., Higuchi, R., and Kim, Y. C. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000;71(1-2):321-323. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Albizia Julibrissin and Protriptyline Together: Common Questions

Is it safe to take Albizia Julibrissin with Protriptyline?
We do not list a known interaction between Albizia Julibrissin and Protriptyline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Albizia Julibrissin and Protriptyline combination checked?
Interactions in our licensed database are recorded against drug classes. Protriptyline is filed under 7 classifications, and Albizia Julibrissin has documented interactions with 1 drug class — none of Protriptyline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Albizia Julibrissin interact with any other medications?
Yes. Albizia Julibrissin has 248 documented drug interactions in our database — Protriptyline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Protriptyline interact with any supplements?
Yes. Protriptyline has documented interactions with 93 supplements in our database — Albizia Julibrissin is not one of them. The Protriptyline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Albizia Julibrissin monograph Uses, safety profile, and every drug interaction in one place Protriptyline drug information The full plain-English guide to this medication Protriptyline supplement interactions Every supplement checked against Protriptyline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Protriptyline and Albizia Julibrissin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.