Drug & supplement interaction

Allspice + Diphenhydramine, Zinc Oxide

Diphenhydramine, Zinc Oxide brand name: Caladryl Clear.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Allspice and Diphenhydramine, Zinc Oxide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Allspice and Diphenhydramine, Zinc Oxide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diphenhydramine, Zinc Oxide and Allspice in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Allspice safety at a glance

Allspice overall Use caution Food amounts are generally safe, but concentrated extracts and essential oil need caution and lack strong safety data.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diphenhydramine, Zinc Oxide and Allspice? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diphenhydramine, Zinc Oxide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diphenhydramine, Zinc Oxide is filed under 2 classifications — cytochrome p450 2d6 (cyp2d6) inhibitors, topical drugs. Allspice has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Diphenhydramine, Zinc Oxide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Allspice Does Interact With Other Medications

Allspice has 122 moderate known drug interactions in our database — Diphenhydramine, Zinc Oxide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Diphenhydramine, Zinc Oxide)
Taking anything else?

Check Another of Your Medications Against Allspice

Covers the 2,830 medications we’ve checked against Allspice. Pick one to open its full report.

What to actually watch for

What Allspice Itself Has Been Linked To

This is not an interaction — nothing below involves Diphenhydramine, Zinc Oxide. It is the side-effect record for Allspice on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Allspice, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Shortness of breath / A severe allergic reaction / Hives / An allergic reaction Worth acting on Additional detail

    “Orally and topically, allspice can cause allergic dermatitis in sensitive people. A case report describes a 41-year-old female with a history of allergic reactions to certain foods and drinks, with symptoms including lip angioedema, generalized hives and urticaria, vomiting, difficulty breathing, sneezing, ocular pruritus, and lacrimation, which responded to oral diphenhydramine.”

    Allspice · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 12635. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
    2. 30654. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
    3. 109925. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed
  • Itching / A skin rash / Vomiting Additional detail

    Recorded for Allspice in the same Natural Medicines adverse-effect record shown under Shortness of breath / A severe allergic reaction / Hives / An allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Allspice — expand a row for the licensed statement it rests on. We haven’t matched Diphenhydramine, Zinc Oxide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Diphenhydramine, Zinc Oxide.

Special populations

Allspice in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amounts as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Diphenhydramine, Zinc Oxide

This page covers Allspice only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diphenhydramine, Zinc Oxide page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the Diphenhydramine, Zinc Oxide page

“Caladryl Clear, the diphenhydramine and zinc oxide lotion people dab on itchy bites and rashes, carries a short and manageable interaction list. None of its six flagged ingredients rates major; five are moderate and one minor.”

Reviewed by 2 · Jul 18, 2026

Open the Diphenhydramine, Zinc Oxide interaction page

One more smart check

Taking Allspice as Part of a Dietary Supplement Product? Check It for Interactions

We hold 133 real supplement products containing Allspice, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Allspice. Even though Allspice itself has no known interaction with Diphenhydramine, Zinc Oxide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Allspice and Diphenhydramine, Zinc Oxide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Allspice
Top half

#482 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diphenhydramine, Zinc Oxide
Steady interest

#2,066 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Allspice reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Allspice and Diphenhydramine, Zinc Oxide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Allspice

What is Allspice?

Allspice
  • Digestive upset and gas
  • Muscle and joint pain (topical)
  • Toothache and oral discomfort
  • Antimicrobial uses
  • Flavoring in food and drinks

Allspice is a popular cooking spice from a Caribbean evergreen tree that has long been used in folk medicine for digestion, pain, and infections. There is very little high-quality human research to support these medicinal uses, so it is best thought of as a flavorful food rather than a proven treatment. Amounts used in cooking are generally considered safe, but concentrated extracts and the essential oil should be used carefully.

Pimenta dioica · Myrtaceae · Dried unripe berries, leaves, and essential oil · Whole or ground spice, tea, extract, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Allspice is a good idea for someone in your situation. Here is what our Allspice record says about it on its own.

Allspice: dosing

There is no established standard medicinal dose for allspice. Most people only encounter it in the small amounts used to flavor food, which are considered safe.For supplements, teas, or extracts, there is not enough reliable research to recommend a specific amount. If you choose to use a product, follow the directions on the label and do not exceed them.The essential oil is highly concentrated and should only be used externally and well diluted, never taken by mouth without professional guidance.

From our Allspice monograph — the full record covers uses, side effects and every documented interaction.

Read the full Allspice monograph & all interactions
Keep checking

Other Drugs & Allspice

Browse every other medication we’ve checked against Allspice — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Allspice page.

No interaction 2,707 drugs checked — show the list

We also checked Allspice against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Allspice list.

See the full Allspice interactions page
See every supplement checked against Diphenhydramine, Zinc Oxide, ranked by severity
Evidence & sources

Allspice References

The 5 references that drive our Allspice monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  3. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  4. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
  5. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Allspice and Diphenhydramine, Zinc Oxide Together: Common Questions

Is it safe to take Allspice with Diphenhydramine, Zinc Oxide?
We do not list a known interaction between Allspice and Diphenhydramine, Zinc Oxide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Allspice and Diphenhydramine, Zinc Oxide combination checked?
Interactions in our licensed database are recorded against drug classes. Diphenhydramine, Zinc Oxide is filed under 2 classifications, and Allspice has documented interactions with 1 drug class — none of Diphenhydramine, Zinc Oxide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Allspice interact with any other medications?
Yes. Allspice has 122 documented drug interactions in our database — Diphenhydramine, Zinc Oxide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diphenhydramine, Zinc Oxide interact with any supplements?
Yes. Diphenhydramine, Zinc Oxide has documented interactions with 6 supplements in our database — Allspice is not one of them. The Diphenhydramine, Zinc Oxide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Allspice monograph Uses, safety profile, and every drug interaction in one place Diphenhydramine, Zinc Oxide supplement interactions Every supplement checked against Diphenhydramine, Zinc Oxide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diphenhydramine, Zinc Oxide and Allspice?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.