Drug & supplement interaction

Alpha-ketoglutarate (akg) + Carbidopa

Carbidopa brand name: Lodosyn.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Alpha-ketoglutarate (akg) and Carbidopa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alpha-ketoglutarate (akg) and Carbidopa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Carbidopa and Alpha-ketoglutarate (akg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-ketoglutarate (akg) at all — not against Carbidopa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-ketoglutarate (akg) safety at a glance

Alpha-ketoglutarat... overall Use caution Generally tolerated in short-term studies, but long-term human safety data are limited.
Pregnancy Avoid Not enough safety data, so avoid use during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Carbidopa and Alpha-ketoglutarate (akg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Carbidopa’s Own FDA Label Lists

This is not an interaction — none of it involves Alpha-ketoglutarate (akg). These are the most notable effects listed in the ADVERSE REACTIONS section of Carbidopa’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 8.7% of FDA reports for Carbidopa
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • Trouble passing urine Worth acting on
  • A heart attack Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 54 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Carbidopa. Read the label on DailyMed › Where a percentage is shown, it is the share of 52,609 voluntary FDA FAERS reports for Carbidopa that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Alpha-ketoglutarate (akg)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Alpha-ketoglutarate (akg) side to compare — that is a limit of the record, not a statement that Alpha-ketoglutarate (akg) has no side effects.

Everything else you take

See Every Supplement That Interacts With Carbidopa

This page covers Alpha-ketoglutarate (akg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carbidopa page lists 21 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Magnesium (major), 5-htp (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).

By severity: 2 major · 10 moderate · 9 minor.

From our pharmacist’s overview on the Carbidopa page

“Carbidopa (Lodosyn) keeps levodopa working in Parkinson's disease, so anything that blocks its absorption can cost real motor control, and two of the 21 supplements on this list do exactly that at a level rated major. Magnesium is the one that surprises people: in a human study it cut carbidopa absorption by 81 percent and levodopa's b…”

Reviewed by 2 · Jul 18, 2026

Open the Carbidopa interaction page

How much people look this up

Where Alpha-ketoglutarate (akg) and Carbidopa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-ketoglutarate (akg)
Steady interest

#1,377 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carbidopa
Top 25%

#599 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-ketoglutarate (akg) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-ketoglutarate (akg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alpha-ketoglutarate (akg) and Carbidopa records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpha-ketoglutarate (akg)

What is Alpha-ketoglutarate (akg)?

Alpha-ketoglutarate (akg)
  • Anti-aging and longevity support
  • Athletic performance and recovery
  • Muscle building
  • Bone health
  • General metabolic and energy support

Alpha-ketoglutarate (AKG) is a natural molecule in the body's energy-making (Krebs) cycle that is now sold as a supplement, mainly marketed for longevity, exercise, and muscle support. Most human evidence is limited or early, and many popular claims rest on lab or animal studies, so benefits are not well proven. Talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have a health condition.

Not applicable (a naturally occurring metabolic molecule, made synthetically for supplements) · Capsules, tablets, powders; often as calcium alpha-ketoglutarate (Ca-AKG), arginine alpha-ketoglutarate (AAKG), or ornithine alpha-ketoglutarate (OKG)

An interaction check asks whether these two react with each other — it does not ask whether Alpha-ketoglutarate (akg) is a good idea for someone in your situation. Here is what our Alpha-ketoglutarate (akg) record says about it on its own.

Alpha-ketoglutarate (akg): dosing

There is no official, established dose of AKG for any health condition. Doses used in studies have varied widely depending on the form (calcium AKG, arginine AKG, or ornithine AKG) and the purpose.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Alpha-ketoglutarate (akg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-ketoglutarate (akg) monograph & all interactions
Medication

About Carbidopa

What Is Carbidopa Used For?

Brand name: Lodosyn

Carbidopa tablets — sold under the brand name Lodosyn and as generic carbidopa — are used together with levodopa or carbidopa-levodopa to manage symptoms of Parkinson's disease, postencephalitic parkinsonism, and symptomatic parkinsonism that can result from carbon monoxide or manganese poisoning. Carbidopa is never used alone; it always works as a partner to levodopa-based therapy.

Lodosyn is specifically used when a patient taking carbidopa-levodopa isn't getting enough daily carbidopa from that combination, or when a patient needs the two drugs individually titrated (adjusted) rather than taken as a fixed combination. Adding carbidopa helps reduce the nausea and vomiting that levodopa often causes and allows lower doses of levodopa to be used.

Most-Reported Side Effects for Carbidopa

From FAERS, the FDA’s public side-effect reporting system (52,609 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 4,954 reports
Hallucination 4,554 reports
Tremor 3,533 reports
Dyskinesia 3,174 reports
Dizziness 2,837 reports
See full Carbidopa drug information
Keep checking

Other Drugs & Alpha-ketoglutarate (akg)

Browse every other medication we’ve checked against Alpha-ketoglutarate (akg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Alpha-ketoglutarate (akg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-ketoglutarate (akg) list.

See the full Alpha-ketoglutarate (akg) interactions page
See every supplement checked against Carbidopa, ranked by severity
Evidence & sources

Alpha-ketoglutarate (akg) References

The 2 sources that drive our Alpha-ketoglutarate (akg) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-ketoglutarate (akg) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Arginine — NIH Office of Dietary Supplements / MedlinePlus Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-ketoglutarate (akg) and Carbidopa Together: Common Questions

Is it safe to take Alpha-ketoglutarate (akg) with Carbidopa?
We do not list a known interaction between Alpha-ketoglutarate (akg) and Carbidopa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Carbidopa interact with any supplements?
Yes. Carbidopa has documented interactions with 21 supplements in our database — Alpha-ketoglutarate (akg) is not one of them. The Carbidopa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alpha-ketoglutarate (akg) monograph Uses, safety profile, and every drug interaction in one place Carbidopa drug information The full plain-English guide to this medication Carbidopa supplement interactions Every supplement checked against Carbidopa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Carbidopa and Alpha-ketoglutarate (akg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.