Drug & supplement interaction

Alpha-ketoglutarate (akg) + Iopamidol

Iopamidol brand name: Isovue.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Alpha-ketoglutarate (akg) and Iopamidol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Alpha-ketoglutarate (akg) and Iopamidol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Iopamidol and Alpha-ketoglutarate (akg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-ketoglutarate (akg) at all — not against Iopamidol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-ketoglutarate (akg) safety at a glance

Alpha-ketoglutarat... overall Use caution Generally tolerated in short-term studies, but long-term human safety data are limited.

Pregnancy Avoid Not enough safety data, so avoid use during pregnancy.

Breastfeeding Avoid Not enough safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Iopamidol and Alpha-ketoglutarate (akg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Iopamidol’s Own FDA Label Lists

This is not an interaction — none of it involves Alpha-ketoglutarate (akg). These are the most notable effects listed in the ADVERSE REACTIONS section of Iopamidol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Loss of vision Worth acting on
A change in thyroid levels Worth acting on
Hearing loss Worth acting on
Muscle weakness Worth acting on
Trouble passing urine Worth acting on
Unsteadiness Worth acting on
A slow heartbeat Worth acting on
Blood clots Worth acting on
Hallucinations Worth acting on
Fainting Worth acting on

Showing the 10 most notable of 51 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Iopamidol. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,936 voluntary FDA FAERS reports for Iopamidol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Alpha-ketoglutarate (akg)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Alpha-ketoglutarate (akg) side to compare — that is a limit of the record, not a statement that Alpha-ketoglutarate (akg) has no side effects.

Everything else you take

See Every Supplement That Interacts With Iopamidol

This page covers Alpha-ketoglutarate (akg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Iopamidol page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Iopamidol page

“Iopamidol (Isovue) is the contrast dye used to sharpen CT and X-ray images, and the 23 supplements on this list call for genuine care, starting with activated charcoal, the only entry rated major. It heads a group of 17 fibers, gums, and thickeners that can change how much of a medicine taken by mouth actually gets absorbed.”

Reviewed by 2 · Jul 18, 2026

Open the Iopamidol interaction page

How much people look this up

Where Alpha-ketoglutarate (akg) and Iopamidol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-ketoglutarate (akg)

Steady interest

#1,332 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Iopamidol

Steady interest

#2,785 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-ketoglutarate (akg) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-ketoglutarate (akg) reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alpha-ketoglutarate (akg) and Iopamidol records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Alpha-ketoglutarate (akg)

What is Alpha-ketoglutarate (akg)?

Anti-aging and longevity support
Athletic performance and recovery
Muscle building
Bone health
General metabolic and energy support

Alpha-ketoglutarate (AKG) is a natural molecule in the body's energy-making (Krebs) cycle that is now sold as a supplement, mainly marketed for longevity, exercise, and muscle support. Most human evidence is limited or early, and many popular claims rest on lab or animal studies, so benefits are not well proven. Talk with your pharmacist or doctor before starting it, especially if you are pregnant, breastfeeding, or have a health condition.

Not applicable (a naturally occurring metabolic molecule, made synthetically for supplements) · Capsules, tablets, powders; often as calcium alpha-ketoglutarate (Ca-AKG), arginine alpha-ketoglutarate (AAKG), or ornithine alpha-ketoglutarate (OKG)

An interaction check asks whether these two react with each other — it does not ask whether Alpha-ketoglutarate (akg) is a good idea for someone in your situation. Here is what our Alpha-ketoglutarate (akg) record says about it on its own.

Alpha-ketoglutarate (akg): dosing

There is no official, established dose of AKG for any health condition. Doses used in studies have varied widely depending on the form (calcium AKG, arginine AKG, or ornithine AKG) and the purpose.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Alpha-ketoglutarate (akg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-ketoglutarate (akg) monograph & all interactions

Medication

About Iopamidol

Most-Reported Side Effects for Iopamidol

From FAERS, the FDA’s public side-effect reporting system (2,936 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 187 reports

Urticaria 187 reports

Anaphylactic reaction 185 reports

Pruritus 166 reports

Nausea 162 reports

Keep checking

Other Drugs & Alpha-ketoglutarate (akg)

Browse every other medication we’ve checked against Alpha-ketoglutarate (akg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Alpha-ketoglutarate (akg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-ketoglutarate (akg) list.

See the full Alpha-ketoglutarate (akg) interactions page

See every supplement checked against Iopamidol, ranked by severity

Evidence & sources

Alpha-ketoglutarate (akg) References

The 2 sources that drive our Alpha-ketoglutarate (akg) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-ketoglutarate (akg) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Arginine — NIH Office of Dietary Supplements / MedlinePlus Source
Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-ketoglutarate (akg) and Iopamidol Together: Common Questions

Is it safe to take Alpha-ketoglutarate (akg) with Iopamidol?

We do not list a known interaction between Alpha-ketoglutarate (akg) and Iopamidol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Iopamidol interact with any supplements?

Yes. Iopamidol has documented interactions with 23 supplements in our database — Alpha-ketoglutarate (akg) is not one of them. The Iopamidol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alpha-ketoglutarate (akg) monograph Uses, safety profile, and every drug interaction in one place Iopamidol supplement interactions Every supplement checked against Iopamidol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Iopamidol and Alpha-ketoglutarate (akg)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.