Drug & supplement interaction

American Ivy + Modafinil

Modafinil brand names: Provigil, Sparlon, Alertec.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between American Ivy and Modafinil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

American Ivy and Modafinil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Modafinil and American Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ivy safety at a glance

American Ivy overall Use caution Little safety data exists, and the berries are toxic, so use it cautiously and avoid eating any part of the plant.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Modafinil and American Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Modafinil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Modafinil is filed under 9 classifications — including dopamine agonists, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. American Ivy has documented interactions with 1 drug class — the most serious being thiazide diuretics (moderate) — and none of Modafinil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Ivy Does Interact With Other Medications

American Ivy has 56 moderate known drug interactions in our database — Modafinil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 56 No known interaction 2,774 (incl. Modafinil)
Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

What to actually watch for

What Modafinil’s Own FDA Label Lists

This is not an interaction — none of it involves American Ivy. These are the most notable effects listed in the ADVERSE REACTIONS section of Modafinil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. One of them is worth acting on rather than waiting out — marked below.

  • Chest pain Worth acting on
  • Drowsiness mentioned in 4.4% of FDA reports for Modafinil
  • A stuffy or runny nose
  • Anxiety or restlessness mentioned in 4.7% of FDA reports for Modafinil
  • Back pain
  • Trouble sleeping
  • Stomach upset
  • Dizziness
  • Headache mentioned in 5.8% of FDA reports for Modafinil
  • Nausea mentioned in 7.0% of FDA reports for Modafinil

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Modafinil. Read the label on DailyMed › Where a percentage is shown, it is the share of 32,106 voluntary FDA FAERS reports for Modafinil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. American Ivy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Ivy side to compare — that is a limit of the record, not a statement that American Ivy has no side effects.

Everything else you take

See Every Supplement That Interacts With Modafinil

This page covers American Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Modafinil page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (major), Ephedra (major), Grapefruit (major) and Peyote (major).

By severity: 8 major · 150 moderate · 39 minor.

From our pharmacist’s overview on the Modafinil page

“Of the 197 supplements and herbs flagged for modafinil (Provigil, Alertec), eight carry a major rating, and those deserve real caution. Most of the rest fall into two themes.”

Reviewed by 2 · Jul 18, 2026

Open the Modafinil interaction page

How much people look this up

Where American Ivy and Modafinil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy
Steady interest

#1,078 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Modafinil
Top 25%

#421 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Ivy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ivy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Ivy and Modafinil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Ivy

What is American Ivy?

American Ivy
  • Digestive upset
  • To stimulate sweating
  • Traditional tonic use
  • Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Parthenocissus quinquefolia · Vitaceae · Bark, leaves, and stems (berries are considered poisonous) · Dried bark, tinctures, teas; rarely sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether American Ivy is a good idea for someone in your situation. Here is what our American Ivy record says about it on its own.

American Ivy: dosing

There is no established safe or effective dose for American Ivy. It is not a standardized supplement, so the strength of any product can vary a lot.If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Never make a home preparation from the raw plant or its berries.

From our American Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ivy monograph & all interactions
Medication

About Modafinil

What Is Modafinil Used For?

Brand names: Provigil, Sparlon, Alertec

Modafinil (also sold as Provigil) is used to improve wakefulness in adults who experience excessive sleepiness due to narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD).

In OSA, modafinil treats the sleepiness — not the underlying airway obstruction itself. It is used alongside standard treatments such as CPAP (a breathing device worn during sleep), not as a replacement for them. If CPAP is appropriate for you, your doctor will want you to use it consistently even while taking modafinil.

Most-Reported Side Effects for Modafinil

From FAERS, the FDA’s public side-effect reporting system (32,106 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 2,949 reports
Nausea 2,248 reports
Headache 1,870 reports
Fall 1,794 reports
Depression 1,619 reports
See full Modafinil drug information
Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
56Moderate
0Minor
2,773No known interaction
56 Moderate 2,773 No interaction
Moderate

56 interactions

No interaction 2,773 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,773 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page
See every supplement checked against Modafinil, ranked by severity
Evidence & sources

American Ivy References

The 1 sources that drive our American Ivy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Ivy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Oxalates — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ivy and Modafinil Together: Common Questions

Is it safe to take American Ivy with Modafinil?
We do not list a known interaction between American Ivy and Modafinil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the American Ivy and Modafinil combination checked?
Interactions in our licensed database are recorded against drug classes. Modafinil is filed under 9 classifications, and American Ivy has documented interactions with 1 drug class — none of Modafinil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Ivy interact with any other medications?
Yes. American Ivy has 56 documented drug interactions in our database — Modafinil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Modafinil interact with any supplements?
Yes. Modafinil has documented interactions with 197 supplements in our database — American Ivy is not one of them. The Modafinil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ivy monograph Uses, safety profile, and every drug interaction in one place Modafinil drug information The full plain-English guide to this medication Modafinil supplement interactions Every supplement checked against Modafinil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Modafinil and American Ivy?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.