Drug & supplement interaction

American Ivy + Neratinib Maleate

Neratinib Maleate brand name: Nerlynx.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between American Ivy and Neratinib Maleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Neratinib Maleate states a food rule worth keeping to.

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Interaction report

American Ivy and Neratinib Maleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Neratinib Maleate and American Ivy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ivy safety at a glance

American Ivy overall Use caution Little safety data exists, and the berries are toxic, so use it cautiously and avoid eating any part of the plant.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Neratinib Maleate and American Ivy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Neratinib Maleate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Neratinib Maleate is filed under 3 classifications — hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. American Ivy has documented interactions with 1 drug class — the most serious being thiazide diuretics (moderate) — and none of Neratinib Maleate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Ivy Does Interact With Other Medications

American Ivy has 56 moderate known drug interactions in our database — Neratinib Maleate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 56 No known interaction 2,774 (incl. Neratinib Maleate)
Taking anything else?

Check Another of Your Medications Against American Ivy

Covers the 2,830 medications we’ve checked against American Ivy. Pick one to open its full report.

What to actually watch for

What Neratinib Maleate’s Own FDA Label Lists

This is not an interaction — none of it involves American Ivy. These are the most notable effects listed in the ADVERSE REACTIONS section of Neratinib Maleate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Dehydration Worth acting on
  • Kidney problems Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • Diarrhea mentioned in 54.4% of FDA reports for Neratinib Maleate
  • Acne
  • Reduced appetite mentioned in 11.0% of FDA reports for Neratinib Maleate
  • Dry skin

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Neratinib Maleate. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,294 voluntary FDA FAERS reports for Neratinib Maleate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. American Ivy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Ivy side to compare — that is a limit of the record, not a statement that American Ivy has no side effects.

How to take them

Some Neratinib Maleate Products Have a Food Rule — American Ivy Should Not Break It

At least one FDA label for a product containing Neratinib Maleate says to take it with food. If you take American Ivy on an empty stomach out of habit, keep them separate — and take Neratinib Maleate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Neratinib Maleate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 2.2 ) Extended adjuvant treatment of early-stage breast cancer: 240 mg (6 tablets) given orally once daily, with food, continuously until disease recurrence or for up to one year.

From the Dosage and Administration section of the FDA label we read for Neratinib Maleate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Neratinib Maleate

This page covers American Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Neratinib Maleate page lists 168 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 124 moderate · 38 minor.

From our pharmacist’s overview on the Neratinib Maleate page

“This list deserves a careful read, not a quick skim. Neratinib (Nerlynx) treats HER2-positive breast cancer, and 121 of the 168 supplements on file can raise or lower its blood level by acting on CYP3A4, the enzyme that clears it.”

Reviewed by 2 · Jul 18, 2026

Open the Neratinib Maleate interaction page

How much people look this up

Where American Ivy and Neratinib Maleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ivy
Steady interest

#934 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Neratinib Maleate
Top 25%

#472 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Ivy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ivy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The American Ivy and Neratinib Maleate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Ivy

What is American Ivy?

American Ivy
  • Digestive upset
  • To stimulate sweating
  • Traditional tonic use
  • Skin and swelling complaints (topical folk use)

American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there is very little human evidence to support any health benefit. Its berries contain oxalic acid and are considered poisonous, and the plant can irritate the skin. Because safety data is limited, talk with your pharmacist or doctor before using it.

Parthenocissus quinquefolia · Vitaceae · Bark, leaves, and stems (berries are considered poisonous) · Dried bark, tinctures, teas; rarely sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether American Ivy is a good idea for someone in your situation. Here is what our American Ivy record says about it on its own.

American Ivy: dosing

There is no established safe or effective dose for American Ivy. It is not a standardized supplement, so the strength of any product can vary a lot.If you choose to use a product that contains it, follow the directions on the label and do not exceed them. Never make a home preparation from the raw plant or its berries.

From our American Ivy monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ivy monograph & all interactions
Medication

About Neratinib

What Is Neratinib Used For?

Brand name: Nerlynx

Nerlynx (neratinib) is used on its own as extended adjuvant treatment — meaning ongoing therapy after initial treatment is done — for adults with early-stage HER2-positive breast cancer who have already completed trastuzumab-based therapy.

Nerlynx is also used in combination with another chemotherapy drug, capecitabine, for adults with advanced or metastatic (spread) HER2-positive breast cancer who have already received two or more prior HER2-targeted regimens in the metastatic setting.

See full Neratinib drug information
Keep checking

Other Drugs & American Ivy

Browse every other medication we’ve checked against American Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
56Moderate
0Minor
2,773No known interaction
56 Moderate 2,773 No interaction
Moderate

56 interactions

No interaction 2,773 drugs checked — show the list

We also checked American Ivy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,773 medications checked with no known interaction — see the full American Ivy list.

See the full American Ivy interactions page
See every supplement checked against Neratinib Maleate, ranked by severity
Evidence & sources

American Ivy References

The 1 sources that drive our American Ivy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Ivy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Oxalates — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ivy and Neratinib Maleate Together: Common Questions

Is it safe to take American Ivy with Neratinib Maleate?
We do not list a known interaction between American Ivy and Neratinib Maleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take American Ivy and Neratinib Maleate at the same time of day?
At least one FDA label for a product containing Neratinib Maleate says to take it with food. If you take American Ivy on an empty stomach out of habit, keep them separate and take Neratinib Maleate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Neratinib Maleate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the American Ivy and Neratinib Maleate combination checked?
Interactions in our licensed database are recorded against drug classes. Neratinib Maleate is filed under 3 classifications, and American Ivy has documented interactions with 1 drug class — none of Neratinib Maleate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Ivy interact with any other medications?
Yes. American Ivy has 56 documented drug interactions in our database — Neratinib Maleate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Neratinib Maleate interact with any supplements?
Yes. Neratinib Maleate has documented interactions with 168 supplements in our database — American Ivy is not one of them. The Neratinib Maleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ivy monograph Uses, safety profile, and every drug interaction in one place Neratinib drug information The full plain-English guide to this medication Neratinib Maleate supplement interactions Every supplement checked against Neratinib Maleate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Neratinib Maleate and American Ivy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.