Drug & supplement interaction

American Mistletoe + Brexpiprazole

Brexpiprazole brand name: Rexulti.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between American Mistletoe and Brexpiprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

American Mistletoe and Brexpiprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brexpiprazole and American Mistletoe in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Mistletoe safety at a glance

American Mistletoe overall Avoid American mistletoe contains toxic compounds and is not recommended for medicinal use.
Pregnancy Likely Unsafe When used orally. American mistletoe is considered an abortifacient. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brexpiprazole and American Mistletoe? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Brexpiprazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Brexpiprazole is filed under 8 classifications — including dopamine agonists, antipsychotic drugs, serotonergic drugs. American Mistletoe has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (major) and vasodilators (major) — and none of Brexpiprazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Mistletoe Does Interact With Other Medications

American Mistletoe has 190 major, known drug interactions in our database — Brexpiprazole isn’t one of them. If you take anything else, check it against the full list below.

Major 190 No known interaction 2,640 (incl. Brexpiprazole)
Taking anything else?

Check Another of Your Medications Against American Mistletoe

Covers the 2,830 medications we’ve checked against American Mistletoe. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests American Mistletoe and Brexpiprazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on Additional detail

    American Mistletoe

    “Evidence on adverse effects related to American mistletoe is limited to retrospective case reviews from poison control centers. Most reports suggest that American mistletoe may be relatively well tolerated at lower doses.”

    American Mistletoe · Natural Medicines adverse-effect record, reported in cardiac arrest.

    “Orally, large doses of American mistletoe may cause delirium and hallucinations (6).”

    American Mistletoe · Natural Medicines adverse-effect record, reported in delirium.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Brexpiprazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Brexpiprazole. Read the label on DailyMed ›

  • Diarrhea / Nausea Additional detail

    American Mistletoe

    “Orally, American mistletoe can cause acute gastroenteritis. Consuming large doses of American mistletoe may cause nausea, vomiting, and diarrhea. Diarrhea and vomiting from ingestion of American mistletoe can lead to dehydration, hypovolemic shock, and cardiovascular collapse (6).”

    American Mistletoe · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Brexpiprazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Brexpiprazole. Read the label on DailyMed ›

Reported for American Mistletoe but not commonly for Brexpiprazole: raised blood pressure, a slow heartbeat, dehydration and vomiting.

Effects for Brexpiprazole come from the ADVERSE REACTIONS section of its FDA label; effects for American Mistletoe come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 16,505 voluntary FDA FAERS reports for Brexpiprazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

American Mistletoe in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. American mistletoe is considered an abortifacient.

Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Brexpiprazole

This page covers American Mistletoe only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brexpiprazole page lists 177 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Indian Snakeroot (major), Lithium (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 130 moderate · 41 minor.

From our pharmacist’s overview on the Brexpiprazole page

“Brexpiprazole (Rexulti) treats schizophrenia and is added to antidepressants for depression, and its supplement list warrants real care before you add anything to it. The bulk of the 177 entries change how your liver clears the drug, so grapefruit can push levels up while St.”

Reviewed by 2 · Jul 18, 2026

Open the Brexpiprazole interaction page

How much people look this up

Where American Mistletoe and Brexpiprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Mistletoe
Steady interest

#1,039 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brexpiprazole
Steady interest

#1,435 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Mistletoe reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Mistletoe and Brexpiprazole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Mistletoe

What is American Mistletoe?

American Mistletoe
  • Traditional folk remedies
  • Digestive complaints
  • Decorative holiday plant

American mistletoe is a parasitic plant that is best known as a holiday decoration, not a proven medicine. It contains toxins that can harm the heart, gut, and blood vessels, and it has little reliable evidence to support any health use. We do not recommend taking it, and all parts should be kept away from children and pets.

Phoradendron leucarpum · Santalaceae · Leaves, stems, and berries · Rarely used as a supplement; historically as tea or dried plant. Most often seen as a holiday decoration.

An interaction check asks whether these two react with each other — it does not ask whether American Mistletoe is a good idea for someone in your situation. Here is what our American Mistletoe record says about it on its own.

American Mistletoe: dosing

There is no established safe or effective dose of American mistletoe. Because the plant is toxic and not recommended for medicinal use, no dosing guidance can be given.If you ever see a product containing mistletoe, do not take it without first speaking to a pharmacist or doctor. The safest approach is to avoid using American mistletoe internally altogether.

From our American Mistletoe monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Mistletoe monograph & all interactions
Medication

About Brexpiprazole

What Is Brexpiprazole Used For?

Brand name: Rexulti

Brexpiprazole tablets are approved for two uses in adults: as an add-on (adjunctive) treatment alongside antidepressants for major depressive disorder (MDD), and as a treatment for schizophrenia. These uses apply to both the generic brexpiprazole tablets and Rexulti.

Rexulti has one additional approved use: treating agitation associated with dementia due to Alzheimer's disease in adults. Rexulti is also approved for schizophrenia in adolescents ages 13 and older. Note that Rexulti is not approved for dementia-related psychosis without agitation from Alzheimer's disease, and it is not meant to be used on an as-needed basis for Alzheimer's-related agitation.

Most-Reported Side Effects for Brexpiprazole

From FAERS, the FDA’s public side-effect reporting system (16,505 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Weight increased 1,702 reports
Akathisia 869 reports
Tremor 654 reports
Anxiety 612 reports
Tardive dyskinesia 599 reports
See full Brexpiprazole drug information
Keep checking

Other Drugs & American Mistletoe

Browse every other medication we’ve checked against American Mistletoe — both the ones with a known interaction and the ones without. Select any drug for the full detail.

190Major
0Moderate
0Minor
2,639No known interaction
190 Major 2,639 No interaction
Major

190 interactions

Showing 60 of 190 major interactions — see all 190 on the American Mistletoe page.

No interaction 2,639 drugs checked — show the list

We also checked American Mistletoe against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,639 medications checked with no known interaction — see the full American Mistletoe list.

See the full American Mistletoe interactions page
See every supplement checked against Brexpiprazole, ranked by severity
Evidence & sources

American Mistletoe References

The 4 references that drive our American Mistletoe monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
  4. Moore HW. Mistletoe poisoning: a review of the available literature, and the report of a case of probable fatal poisoning. J S Carolina Med Assoc 1963;59(8):269-271.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Mistletoe and Brexpiprazole Together: Common Questions

Is it safe to take American Mistletoe with Brexpiprazole?
We do not list a known interaction between American Mistletoe and Brexpiprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do American Mistletoe and Brexpiprazole have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the American Mistletoe and Brexpiprazole combination checked?
Interactions in our licensed database are recorded against drug classes. Brexpiprazole is filed under 8 classifications, and American Mistletoe has documented interactions with 2 drug classes — none of Brexpiprazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Mistletoe interact with any other medications?
Yes. American Mistletoe has 190 documented drug interactions in our database — Brexpiprazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Brexpiprazole interact with any supplements?
Yes. Brexpiprazole has documented interactions with 177 supplements in our database — American Mistletoe is not one of them. The Brexpiprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Mistletoe monograph Uses, safety profile, and every drug interaction in one place Brexpiprazole drug information The full plain-English guide to this medication Brexpiprazole supplement interactions Every supplement checked against Brexpiprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Brexpiprazole and American Mistletoe?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.