Drug & supplement interaction

Amino Acid Therapy + Zileuton

Zileuton brand names: Zyflo, Zyflo CR.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Amino Acid Therapy and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.

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Interaction report

Amino Acid Therapy and Zileuton

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zileuton and Amino Acid Therapy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Amino Acid Therapy at all — not against Zileuton, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Amino Acid Therapy safety at a glance

Amino Acid Therapy overall Use caution Most amino acids are reasonably safe in food amounts, but high-dose supplements should be used carefully.
Pregnancy Use caution A balanced diet provides amino acids; high-dose supplements during pregnancy are not well studied, so avoid unless advised by a doctor.
Breastfeeding Use caution Safety of high-dose amino acid supplements while breastfeeding is not well established, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zileuton and Amino Acid Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Zileuton’s Own FDA Label Lists

This is not an interaction — none of it involves Amino Acid Therapy. These are the most notable effects listed in the ADVERSE REACTIONS section of Zileuton’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on mentioned in 11.9% of FDA reports for Zileuton
  • Liver problems Worth acting on
  • An allergic reaction Worth acting on
  • Stomach upset
  • Stomach pain
  • Nausea mentioned in 6.3% of FDA reports for Zileuton
  • Diarrhea
  • A skin rash
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Zileuton. Read the label on DailyMed › Where a percentage is shown, it is the share of 637 voluntary FDA FAERS reports for Zileuton that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Amino Acid Therapy’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Amino Acid Therapy side to compare — that is a limit of the record, not a statement that Amino Acid Therapy has no side effects.

How to take them

Some Zileuton Products Have a Food Rule — Amino Acid Therapy Should Not Break It

At least one FDA label for a product containing Zileuton says to take it with food. If you take Amino Acid Therapy on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For ease of administration, ZYFLO may be taken with meals and at bedtime.

From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Zileuton

This page covers Amino Acid Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 163 moderate · 44 minor.

Open the Zileuton interaction page

How much people look this up

Where Amino Acid Therapy and Zileuton Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Amino Acid Therapy
Steady interest

#1,241 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zileuton
Steady interest

#1,700 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Amino Acid Therapy is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Amino Acid Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Amino Acid Therapy and Zileuton records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Amino Acid Therapy

What is Amino Acid Therapy?

  • Muscle building and recovery
  • Mood and sleep support
  • Fatigue and energy
  • Nutritional support
  • Wound healing

Amino acid therapy means using individual amino acids (the building blocks of protein) as supplements to support muscle, mood, sleep, or general nutrition. Some specific amino acids have good evidence for certain uses, but the broad idea of treating many conditions with custom amino acid blends is not well proven. Talk to your pharmacist or doctor before starting, especially if you have kidney or liver problems.

Individual amino acids (building blocks of protein) · Capsules, tablets, powders, intravenous (IV) solutions, and protein-based supplements

An interaction check asks whether these two react with each other — it does not ask whether Amino Acid Therapy is a good idea for someone in your situation. Here is what our Amino Acid Therapy record says about it on its own.

Amino Acid Therapy: dosing

There is no single standard dose for "amino acid therapy," because the right amount depends on the specific amino acid and the reason you are taking it. Doses studied for one amino acid do not apply to others.The safest approach is to follow the directions on the product label and not exceed them. They can help you decide whether a supplement is appropriate and at what amount.

From our Amino Acid Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Amino Acid Therapy monograph & all interactions
Medication

About Zileuton

What Is Zileuton Used For?

Brand names: Zyflo, Zyflo CR

Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.

Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.

See full Zileuton drug information
Keep checking

Other Drugs & Amino Acid Therapy

Browse every other medication we’ve checked against Amino Acid Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Amino Acid Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Amino Acid Therapy list.

See the full Amino Acid Therapy interactions page
See every supplement checked against Zileuton, ranked by severity
Evidence & sources

Amino Acid Therapy References

The 3 sources that drive our Amino Acid Therapy monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Amino Acid Therapy is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Amino Acid Therapy and Zileuton Together: Common Questions

Is it safe to take Amino Acid Therapy with Zileuton?
We do not list a known interaction between Amino Acid Therapy and Zileuton. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Amino Acid Therapy and Zileuton at the same time of day?
At least one FDA label for a product containing Zileuton says to take it with food. If you take Amino Acid Therapy on an empty stomach out of habit, keep them separate and take Zileuton with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Zileuton products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Zileuton interact with any supplements?
Yes. Zileuton has documented interactions with 213 supplements in our database — Amino Acid Therapy is not one of them. The Zileuton interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Amino Acid Therapy monograph Uses, safety profile, and every drug interaction in one place Zileuton drug information The full plain-English guide to this medication Zileuton supplement interactions Every supplement checked against Zileuton, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zileuton and Amino Acid Therapy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.