Drug & supplement interaction

Androstenedione + Paliperidone Palmitate

Paliperidone Palmitate brand name: Invega Trinza.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Androstenedione and Paliperidone Palmitate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androstenedione and Paliperidone Palmitate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paliperidone Palmitate and Androstenedione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenedione safety at a glance

Androstenedione overall Avoid It is a controlled substance with hormonal risks and little proven benefit.
Pregnancy Likely Unsafe When used orally. Androstenedione might induce labor. Read the full pregnancy detail
Breastfeeding Avoid It is unsafe and not recommended while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paliperidone Palmitate and Androstenedione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Paliperidone Palmitate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Paliperidone Palmitate is filed under 3 classifications — antipsychotic drugs, qt interval-prolonging drugs, seizure threshold lowering drugs. Androstenedione has documented interactions with 1 drug class — the most serious being estrogens (moderate) — and none of Paliperidone Palmitate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenedione Does Interact With Other Medications

Androstenedione has 41 moderate known drug interactions in our database — Paliperidone Palmitate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 No known interaction 2,789 (incl. Paliperidone Palmitate)
Taking anything else?

Check Another of Your Medications Against Androstenedione

Covers the 2,830 medications we’ve checked against Androstenedione. Pick one to open its full report.

What to actually watch for

What Androstenedione Itself Has Been Linked To

This is not an interaction — nothing below involves Paliperidone Palmitate. It is the side-effect record for Androstenedione on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Androstenedione, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    “There is some concern that androstenedione might cause or worsen depression in women. Some women with severe major depression seem to have increased endogenous androstenedione concentrations; however, it is not known if supplements can actually cause this adverse effect.”

    Androstenedione · Natural Medicines adverse-effect record, reported in depression.

    1 source cited
    1. 6796. Weber B, Lewicka S, Deuschle M, et al. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 2000;25:765-71. PubMed
  • Liver problems Worth acting on Additional detail

    “Orally, androstenedione may be unsafe.

    Serious Adverse Effects (Rare):

    Orally: hepatotoxicity; breast and endometrial cancer (females); pancreatic and prostate cancer (males); and adverse genitourinary effects.”

    Androstenedione · Natural Medicines adverse-effect record, reported in cancer.

  • A change in sex drive / Breast tenderness / Erection problems Additional detail

    “Orally, androstenedione possibly alters levels of estrogen and testosterone in men. Theoretically, this might cause decreased spermatogenesis, gynecomastia, testicular atrophy, and prostate hypertrophy. There is one case report of two episodes of priapism associated with androstenedione use in a 30-year-old man.”

    Androstenedione · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).

    6 sources cited
    1. 1905. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
    2. 3861. Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82. PubMed
    3. 6000. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8. PubMed
    4. 7236. Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80. DOI
    5. 8138. Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. PubMed
    6. 97845. Judge LW, Bellar DM, Hoover DL, Biggs D, Leitzelar BN, Craig BW. Effects of acute androstenedione supplementation on testosterone levels in older men. Aging Male. 2016;19(3):161-167. PubMed
  • Acne Additional detail

    “Orally, androstenedione might cause acne in men by decreasing endogenous testosterone production and increasing estrogen. In women, androstenedione might cause male-pattern baldness, hair growth, acne, and coarsening of the skin.”

    Androstenedione · Natural Medicines adverse-effect record, reported in acne.

    2 sources cited
    1. 674. Anon. Creatine and androstenedione, two dietary supplements. Med Lett Drugs Ther 1998;40:105-6.
    2. 111132. Badawy MT, Sobeh M, Xiao J, Farag MA. Androstenedione (a natural steroid and a drug supplement): a comprehensive review of its consumption, metabolism, health effects, and toxicity with sex differences. Molecules 2021;26(20):6210. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Androstenedione — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Paliperidone Palmitate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Paliperidone Palmitate column appears here.

Special populations

Androstenedione in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Androstenedione might induce labor.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Paliperidone Palmitate

This page covers Androstenedione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paliperidone Palmitate page lists 27 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 8 major · 18 moderate · 1 minor.

From our pharmacist’s overview on the Paliperidone Palmitate page

“Paliperidone palmitate (Invega Trinza), a long-acting injection for schizophrenia, can lengthen the heart's QT interval on its own, so the supplements on this page deserve real care rather than casual curiosity. Nearly half of the interacting ingredients can stretch that interval further and raise the risk of a dangerous heart rhythm,…”

Reviewed by 2 · Jul 18, 2026

Open the Paliperidone Palmitate interaction page

One more smart check

Taking Androstenedione as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Androstenedione, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androstenedione. Even though Androstenedione itself has no known interaction with Paliperidone Palmitate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androstenedione and Paliperidone Palmitate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenedione
Steady interest

#1,277 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paliperidone Palmitate
Top half

#817 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenedione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Androstenedione and Paliperidone Palmitate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenedione

What is Androstenedione?

Androstenedione
  • Muscle building
  • Athletic performance
  • Boosting testosterone
  • Anti-aging
  • Increasing libido

Androstenedione is a prohormone that the body can convert into testosterone and estrogen, but studies have not shown that taking it reliably builds muscle or improves athletic performance. It carries real risks, is a controlled substance in the United States, and is banned in nearly all sports, so most people should avoid it.

Not a plant; a hormone precursor made synthetically or in the body · Capsules, tablets, sublingual sprays, powders (where legally available)

An interaction check asks whether these two react with each other — it does not ask whether Androstenedione is a good idea for someone in your situation. Here is what our Androstenedione record says about it on its own.

Androstenedione: dosing

There is no established safe or effective dose for androstenedione. Past products varied widely, and because it is now a controlled substance, it is not appropriate to recommend any amount.If you encounter a product containing it, do not assume the label dose is safe or accurate. The safest choice is to avoid it.

From our Androstenedione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenedione monograph & all interactions
Medication

About Paliperidone Injection

What Is Paliperidone Injection Used For?

Brand name: Invega Trinza

Paliperidone injection is used to treat schizophrenia and schizoaffective disorder in adults. Different branded products are approved for specific treatment situations.

Invega Sustenna (once-monthly injection) treats both schizophrenia and schizoaffective disorder. Invega Trinza (every-three-month injection) and Invega Hafyera (every-six-month injection) treat schizophrenia in adults who have already been stabilized on a paliperidone palmitate injectable. Erzofri extended-release is a once-monthly injectable for schizophrenia and schizoaffective disorder in adults.

Most-Reported Side Effects for Paliperidone Palmitate

From FAERS, the FDA’s public side-effect reporting system (31,995 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hospitalisation 1,803 reports
Weight increased 1,655 reports
Schizophrenia 1,127 reports
Gynaecomastia 1,085 reports
Treatment noncompliance 947 reports
See full Paliperidone Injection drug information
Keep checking

Other Drugs & Androstenedione

Browse every other medication we’ve checked against Androstenedione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
0Minor
2,788No known interaction
41 Moderate 2,788 No interaction
Moderate

41 interactions

No interaction 2,788 drugs checked — show the list

We also checked Androstenedione against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,788 medications checked with no known interaction — see the full Androstenedione list.

See the full Androstenedione interactions page
See every supplement checked against Paliperidone Palmitate, ranked by severity
Evidence & sources

Androstenedione References

The 21 references that drive our Androstenedione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. van Weerden WM, van Kreuningen A, Elissen NM, et al. Effects of adrenal androgens on the transplantable human prostate tumor PC-82. Endocrinol 1992;131:2909-13.
  2. Mecenas CA, Giussani DA, Owiny JR, et al. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nat Med 1996;2:443-8. PubMed
  3. Anon. Creatine and androstenedione, two dietary supplements. Med Lett Drugs Ther 1998;40:105-6.
  4. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  5. Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82. PubMed
  6. Kachhi PN, Henderson SO. Priapism after androstenedione intake for athletic performance enhancement. Ann Emerg Med 2000;35:391-3. PubMed
  7. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8. PubMed
  8. Weber B, Lewicka S, Deuschle M, et al. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 2000;25:765-71. PubMed
  9. Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80. DOI
  10. Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. PubMed
  11. Leder, B. Z., Leblanc, K. M., Longcope, C., Lee, H., Catlin, D. H., and Finkelstein, J. S. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2002;87(12):5449-5454. PubMed
  12. Brown, G. A., Vukovich, M., and King, D. S. Testosterone prohormone supplements. Med Sci Sports Exerc 2006;38(8):1451-1461. PubMed
  13. Cauley, J. A., Lucas, F. L., Kuller, L. H., Stone, K., Browner, W., and Cummings, S. R. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group. Ann Intern PubMed
  14. Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., and King, D. S. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-age
  15. Barrett-Connor, E., Garland, C., McPhillips, J. B., Khaw, K. T., and Wingard, D. L. A prospective, population-based study of androstenedione, estrogens, and prostatic cancer. Cancer Res 1-1-1990;50(1):169-173.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenedione and Paliperidone Palmitate Together: Common Questions

Is it safe to take Androstenedione with Paliperidone Palmitate?
We do not list a known interaction between Androstenedione and Paliperidone Palmitate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Androstenedione and Paliperidone Palmitate combination checked?
Interactions in our licensed database are recorded against drug classes. Paliperidone Palmitate is filed under 3 classifications, and Androstenedione has documented interactions with 1 drug class — none of Paliperidone Palmitate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenedione interact with any other medications?
Yes. Androstenedione has 41 documented drug interactions in our database — Paliperidone Palmitate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Paliperidone Palmitate interact with any supplements?
Yes. Paliperidone Palmitate has documented interactions with 27 supplements in our database — Androstenedione is not one of them. The Paliperidone Palmitate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androstenedione monograph Uses, safety profile, and every drug interaction in one place Paliperidone Injection drug information The full plain-English guide to this medication Paliperidone Palmitate supplement interactions Every supplement checked against Paliperidone Palmitate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paliperidone Palmitate and Androstenedione?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.