Angostura + Atazanavir
Atazanavir brand name: Reyataz.
We found no known interaction between Angostura and Atazanavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atazanavir states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Angostura and Atazanavir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Atazanavir and Angostura in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Angostura at all — not against Atazanavir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Angostura safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Atazanavir Products Have a Food Rule — Angostura Should Not Break It
At least one FDA label for a product containing Atazanavir says to take it with food. If you take Angostura on an empty stomach out of habit, keep them separate — and take Atazanavir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atazanavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
b For adult patients who cannot swallow the capsules, REYATAZ oral powder is taken once daily with food at the same recommended adult dosage as the capsules along with ritonavir.
From the Dosage and Administration section of the FDA label we read for Atazanavir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Atazanavir
This page covers Angostura only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atazanavir page lists 152 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 107 moderate · 42 minor.
From our pharmacist’s overview on the Atazanavir page
“Atazanavir (Reyataz) treats HIV, and keeping its blood level steady is what stands between viral control and drug resistance, so I read this list with genuine care. Of the 152 supplement and herbal ingredients on file, three carry a major rating: St.”
Reviewed by 2 · Jul 18, 2026
Taking Angostura as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Angostura, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angostura. Even though Angostura itself has no known interaction with Atazanavir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Angostura and Atazanavir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,292 of 1,452 supplements looked up here in the last 7 days
#1,544 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angostura reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Angostura and Atazanavir records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Angostura
What is Angostura?
- Digestive upset and poor appetite
- Fever
- Diarrhea
- Malaria prevention (traditional)
- Muscle spasms
Angostura is the bark of a South American tree traditionally used to ease digestion, fevers, and stomach problems. Modern human evidence to support these uses is very limited, and large doses can cause vomiting and other harmful effects. It is best known today as a historic flavoring ingredient, and you should talk with a pharmacist or doctor before using it medicinally.
Angostura trifoliata · Rutaceae · Bark · Bark powder, tincture, extract, and as a flavoring in some alcoholic beverages
An interaction check asks whether these two react with each other — it does not ask whether Angostura is a good idea for someone in your situation. Here is what our Angostura record says about it on its own.
Angostura: dosing
There is no well-established, standardized medicinal dose for angostura. Traditional uses vary widely, and there is not enough reliable research to recommend a safe and effective amount.If you choose to use a product that contains angostura, follow the directions on the product label and do not exceed them, since larger amounts can cause vomiting and diarrhea.
From our Angostura monograph — the full record covers uses, side effects and every documented interaction.
About Atazanavir
What Is Atazanavir Used For?
Brand name: Reyataz
Atazanavir capsules are used together with other antiretroviral medicines to treat HIV-1 infection in adults and in children 6 years and older who weigh at least 15 kg (about 33 lbs).
Reyataz — available as capsules and as an oral powder — is also approved for HIV-1 treatment in adults and in children as young as 3 months who weigh at least 5 kg (about 11 lbs). Reyataz oral powder must always be taken with ritonavir and food, and is not for use in children weighing less than 5 kg.
Most-Reported Side Effects for Atazanavir
From FAERS, the FDA’s public side-effect reporting system (14,470 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Angostura
Browse every other medication we’ve checked against Angostura — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Angostura against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Angostura list.
Angostura References
The 2 references that drive our Angostura monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Angostura and Atazanavir Together: Common Questions
Is it safe to take Angostura with Atazanavir?
Do Angostura and Atazanavir have any of the same side effects?
Should I take Angostura and Atazanavir at the same time of day?
Does Atazanavir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Atazanavir and Angostura?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.