Drug & supplement interaction

Anhydrous Crystalline Maltose + Larotrectinib

Larotrectinib brand name: Vitrakvi.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Anhydrous Crystalline Maltose and Larotrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Anhydrous Crystalline Maltose and Larotrectinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Larotrectinib and Anhydrous Crystalline Maltose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Anhydrous Crystalline Maltose safety at a glance

Anhydrous Crystall... overall Use caution Generally well tolerated in studies, but it is a sugar, so people with diabetes should be cautious.
Pregnancy Use caution Not well studied as a supplement in pregnancy; check with your doctor before use.
Breastfeeding Use caution Not well studied during breastfeeding; check with your doctor before use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Larotrectinib and Anhydrous Crystalline Maltose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Larotrectinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Larotrectinib is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Anhydrous Crystalline Maltose has documented interactions with 1 drug class — the most serious being antidiabetes drugs (minor) — and none of Larotrectinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Anhydrous Crystalline Maltose Does Interact With Other Medications

Anhydrous Crystalline Maltose has 86 minor known drug interactions in our database — Larotrectinib isn’t one of them. If you take anything else, check it against the full list below.

Minor 86 No known interaction 2,744 (incl. Larotrectinib)
Taking anything else?

Check Another of Your Medications Against Anhydrous Crystalline Maltose

Covers the 2,830 medications we’ve checked against Anhydrous Crystalline Maltose. Pick one to open its full report.

What to actually watch for

What Larotrectinib’s Own FDA Label Lists

This is not an interaction — none of it involves Anhydrous Crystalline Maltose. These are the most notable effects listed in the ADVERSE REACTIONS section of Larotrectinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on
  • Hallucinations Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • Liver problems Worth acting on

Showing the 10 most notable of 38 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Larotrectinib. Read the label on DailyMed › Anhydrous Crystalline Maltose’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Anhydrous Crystalline Maltose side to compare — that is a limit of the record, not a statement that Anhydrous Crystalline Maltose has no side effects.

Everything else you take

See Every Supplement That Interacts With Larotrectinib

This page covers Anhydrous Crystalline Maltose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Larotrectinib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Larotrectinib page

“Nearly everything on this page interacts with larotrectinib (Vitrakvi) in one of two directions, raising or lowering how much of the drug ends up in your blood. Larotrectinib treats cancers driven by an NTRK gene fusion, and it is cleared by a liver enzyme called CYP3A4, so herbs that speed that enzyme up can drain the drug's effect wh…”

Reviewed by 2 · Jul 18, 2026

Open the Larotrectinib interaction page

How much people look this up

Where Anhydrous Crystalline Maltose and Larotrectinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Anhydrous Crystalline Maltose
Steady interest

#1,174 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Larotrectinib
Steady interest

#2,090 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Anhydrous Crystalline Maltose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Anhydrous Crystalline Maltose and Larotrectinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Anhydrous Crystalline Maltose

What is Anhydrous Crystalline Maltose?

Anhydrous Crystalline Maltose
  • Dry mouth (xerostomia)
  • Sjögren syndrome
  • Dry mouth from medications
  • Food stabilizer and texturizer

Anhydrous crystalline maltose is a starch-derived sugar (also called malt sugar) studied mainly as a slow-dissolving lozenge to ease dry mouth, including in people with Sjögren syndrome. Some studies suggest it may modestly improve saliva flow, but the overall evidence is limited. It appears generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have diabetes.

Disaccharide sugar derived from starch · Dissolving lozenges, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Anhydrous Crystalline Maltose is a good idea for someone in your situation. Here is what our Anhydrous Crystalline Maltose record says about it on its own.

Anhydrous Crystalline Maltose: dosing

There is no official, standardized supplement dose for anhydrous crystalline maltose. Do not assume more is better.

From our Anhydrous Crystalline Maltose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Anhydrous Crystalline Maltose monograph & all interactions
Medication

About Larotrectinib

What Is Larotrectinib Used For?

Brand name: Vitrakvi

Vitrakvi is used to treat adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion — a specific genetic alteration — without a known acquired resistance mutation. It is used when the tumor has spread (is metastatic) or when surgery would likely cause severe harm, and when there are no satisfactory alternative treatments or the cancer has continued to grow after prior treatment.

Patients are selected for Vitrakvi based on an FDA-approved test that confirms the NTRK gene fusion in tumor tissue. This approval was granted under the FDA's accelerated approval pathway, based on overall response rate and duration of response; continued approval may depend on results from confirmatory trials.

See full Larotrectinib drug information
Keep checking

Other Drugs & Anhydrous Crystalline Maltose

Browse every other medication we’ve checked against Anhydrous Crystalline Maltose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
86Minor
2,743No known interaction
86 Minor 2,743 No interaction
Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Anhydrous Crystalline Maltose page.

No interaction 2,743 drugs checked — show the list

We also checked Anhydrous Crystalline Maltose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Anhydrous Crystalline Maltose list.

See the full Anhydrous Crystalline Maltose interactions page
See every supplement checked against Larotrectinib, ranked by severity
Evidence & sources

Anhydrous Crystalline Maltose References

The 2 references that drive our Anhydrous Crystalline Maltose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Fox, P. C., Cummins, M. J., and Cummins, J. M. Use of orally administered anhydrous crystalline maltose for relief of dry mouth. J Altern Complement Med 2001;7(1):33-43. PubMed
  2. Fox, P. C., Cummins, M. J., and Cummins, J. M. A third study on the use of orally administered anhydrous crystalline maltose for relief of dry mouth in primary Sjogren's syndrome. J Altern Complement Med 2002;8(5):651-659.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Anhydrous Crystalline Maltose and Larotrectinib Together: Common Questions

Is it safe to take Anhydrous Crystalline Maltose with Larotrectinib?
We do not list a known interaction between Anhydrous Crystalline Maltose and Larotrectinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Anhydrous Crystalline Maltose and Larotrectinib combination checked?
Interactions in our licensed database are recorded against drug classes. Larotrectinib is filed under 3 classifications, and Anhydrous Crystalline Maltose has documented interactions with 1 drug class — none of Larotrectinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Anhydrous Crystalline Maltose interact with any other medications?
Yes. Anhydrous Crystalline Maltose has 86 documented drug interactions in our database — Larotrectinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Larotrectinib interact with any supplements?
Yes. Larotrectinib has documented interactions with 143 supplements in our database — Anhydrous Crystalline Maltose is not one of them. The Larotrectinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Anhydrous Crystalline Maltose monograph Uses, safety profile, and every drug interaction in one place Larotrectinib drug information The full plain-English guide to this medication Larotrectinib supplement interactions Every supplement checked against Larotrectinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Larotrectinib and Anhydrous Crystalline Maltose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.