Drug & supplement interaction

Arrach + Naldemedine Tosylate

Naldemedine Tosylate brand name: Symproic.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Arrach and Naldemedine Tosylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Arrach and Naldemedine Tosylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Naldemedine Tosylate and Arrach in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arrach safety at a glance

Arrach overall Not established There is very little modern safety data on Arrach, so use cannot be considered proven safe.
Pregnancy Avoid Traditionally linked to menstrual effects, so it should be avoided during pregnancy.
Breastfeeding Avoid No safety information is available, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Naldemedine Tosylate and Arrach? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Naldemedine Tosylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Naldemedine Tosylate is filed under 3 classifications — p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Arrach has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Naldemedine Tosylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arrach Does Interact With Other Medications

Arrach has 335 moderate known drug interactions in our database — Naldemedine Tosylate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Naldemedine Tosylate)
Taking anything else?

Check Another of Your Medications Against Arrach

Covers the 2,830 medications we’ve checked against Arrach. Pick one to open its full report.

What to actually watch for

What Naldemedine Tosylate’s Own FDA Label Lists

This is not an interaction — none of it involves Arrach. These are the most notable effects listed in the ADVERSE REACTIONS section of Naldemedine Tosylate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on
  • An allergic reaction Worth acting on
  • Chills
  • Tremor or shakiness
  • Flushing
  • Sweating
  • A fast or pounding heartbeat
  • Anxiety or restlessness
  • Stomach upset
  • Fever

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Naldemedine Tosylate. Read the label on DailyMed › Arrach’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Arrach side to compare — that is a limit of the record, not a statement that Arrach has no side effects.

Everything else you take

See Every Supplement That Interacts With Naldemedine Tosylate

This page covers Arrach only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naldemedine Tosylate page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Naldemedine Tosylate page

“Naldemedine (Symproic) relieves constipation caused by opioid painkillers, and this list of 144 supplements deserves real attention, starting with the three rated major: grapefruit, St. John's wort, and activated charcoal.”

Reviewed by 2 · Jul 18, 2026

Open the Naldemedine Tosylate interaction page

How much people look this up

Where Arrach and Naldemedine Tosylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arrach
Steady interest

#774 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naldemedine Tosylate
Top 10%

#177 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arrach reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Arrach and Naldemedine Tosylate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arrach

What is Arrach?

Arrach
  • Painful menstruation
  • Nervous complaints
  • Digestive upset
  • Wound care
  • Insect repellent

Arrach (Chenopodium vulvaria) is a strong-smelling European herb that has been used in traditional folk medicine, mainly for menstrual and nervous complaints. There is very little modern scientific evidence to show that it works or is safe, so it is not recommended, especially during pregnancy or breastfeeding. Talk to your pharmacist or doctor before using any herbal product.

Chenopodium vulvaria · Amaranthaceae · Leaves and aerial (above-ground) parts · Dried herb, tea/infusion, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Arrach is a good idea for someone in your situation. Here is what our Arrach record says about it on its own.

Arrach: dosing

There is no established or standardized dose for Arrach. It is not a common commercial supplement, and reliable dosing information from modern sources does not exist.If you ever come across a product containing Arrach, follow the directions on the label and do not exceed them.

From our Arrach monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arrach monograph & all interactions
Medication

About Naldemedine

What Is Naldemedine Used For?

Brand name: Symproic

Naldemedine (sold as Symproic tablets) treats opioid-induced constipation (OIC). That is constipation caused by taking opioid pain medicine.

It is for adults with chronic non-cancer pain. This includes people with long-term pain related to prior cancer or its treatment who do not need frequent (for example, weekly) increases in their opioid dose.

See full Naldemedine drug information
Keep checking

Other Drugs & Arrach

Browse every other medication we’ve checked against Arrach — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Arrach page.

No interaction 2,494 drugs checked — show the list

We also checked Arrach against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Arrach list.

See the full Arrach interactions page
See every supplement checked against Naldemedine Tosylate, ranked by severity
Evidence & sources

Arrach References

The 1 references that drive our Arrach monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arrach and Naldemedine Tosylate Together: Common Questions

Is it safe to take Arrach with Naldemedine Tosylate?
We do not list a known interaction between Arrach and Naldemedine Tosylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Arrach and Naldemedine Tosylate combination checked?
Interactions in our licensed database are recorded against drug classes. Naldemedine Tosylate is filed under 3 classifications, and Arrach has documented interactions with 1 drug class — none of Naldemedine Tosylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Arrach interact with any other medications?
Yes. Arrach has 335 documented drug interactions in our database — Naldemedine Tosylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Naldemedine Tosylate interact with any supplements?
Yes. Naldemedine Tosylate has documented interactions with 144 supplements in our database — Arrach is not one of them. The Naldemedine Tosylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arrach monograph Uses, safety profile, and every drug interaction in one place Naldemedine drug information The full plain-English guide to this medication Naldemedine Tosylate supplement interactions Every supplement checked against Naldemedine Tosylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Naldemedine Tosylate and Arrach?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.