Drug & supplement interaction

Ascorbigen + Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate

Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate brand name: Plenvu.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate and Ascorbigen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ascorbigen at all — not against Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ascorbigen safety at a glance

Ascorbigen overall Not established There is very little human safety data on ascorbigen as a supplement.
Pregnancy Avoid Safety has not been studied in pregnancy, so it is best to avoid it.
Breastfeeding Avoid No safety data exist for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate and Ascorbigen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas Additional detail

    Ascorbigen

    “Orally, when used in combination with broccoli powder, ascorbigen has been reported to cause flatulence, abdominal distension, and unpleasant after taste. It is unclear if these effects are due to ascorbigen, broccoli powder, or the combination.”

    Ascorbigen · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 15460. Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 2000;5:455-62.

    Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate

    Listed in the ADVERSE REACTIONS section of the FDA label for Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate. Read the label on DailyMed ›

Effects for Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate come from the ADVERSE REACTIONS section of its FDA label; effects for Ascorbigen come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate

This page covers Ascorbigen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate page

“Plenvu, the bowel prep combining polyethylene glycol 3350, ascorbic acid, and electrolyte salts to clear the colon before a colonoscopy, carries 17 supplement interactions, and all of them play out in the gut itself. This is a list worth reading carefully rather than skimming.”

Reviewed by 2 · Jul 18, 2026

Open the Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate interaction page

One more smart check

Taking Ascorbigen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Ascorbigen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ascorbigen. Even though Ascorbigen itself has no known interaction with Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ascorbigen
Steady interest

#1,438 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate
Steady interest

#1,783 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ascorbigen reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ascorbigen

What is Ascorbigen?

Ascorbigen
  • Antioxidant support
  • Immune support
  • Fibromyalgia symptoms
  • General wellness
  • Detoxification support

Ascorbigen is a natural compound formed when indole-3-carbinol (from cruciferous vegetables) combines with vitamin C, and it is mainly studied in the lab and in early research. There is not enough good human evidence to confirm it helps any specific health condition, and its safety as a supplement is not well established. Talk with your pharmacist or doctor before taking it.

Derived from cruciferous vegetables (such as cabbage, broccoli, Brussels sprouts) · Capsules, tablets, found naturally in cruciferous vegetables and some combination supplements

An interaction check asks whether these two react with each other — it does not ask whether Ascorbigen is a good idea for someone in your situation. Here is what our Ascorbigen record says about it on its own.

Ascorbigen: dosing

There is no established standard dose for ascorbigen. It has not been studied enough in humans to know a safe and effective amount.If you choose to use a product that contains ascorbigen, follow the directions on the label and do not exceed the recommended amount.

From our Ascorbigen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ascorbigen monograph & all interactions
Medication

About Polyethylene glycol-electrolyte solution (PEG-ES)

What Is Polyethylene glycol-electrolyte solution (PEG-ES) Used For?

Brand name: Plenvu

  • Polyethylene glycol-electrolyte solution (PEG-ES) is used to empty the colon (large intestine, bowel) before a colonoscopy (examination of the inside of the colon to check for colon cancer and other abnormalities) or barium enema (a test in which the colon is filled with a fluid and then x-rays are taken) so that the doctor will have a clear view of the walls of the colon. PEG-ES is in a class of medications called osmotic laxatives. It works by causing watery diarrhea so that the stool can be emptied from the colon. The medication also contains electrolytes to prevent dehydration and other serious side effects that may be caused by fluid loss as the colon is emptied.

See full Polyethylene glycol-electrolyte solution (PEG-ES) drug information
Keep checking

Other Drugs & Ascorbigen

Browse every other medication we’ve checked against Ascorbigen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Ascorbigen References

The 1 references that drive our Ascorbigen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 2000;5:455-62.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate Together: Common Questions

Is it safe to take Ascorbigen with Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate?
We do not list a known interaction between Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ascorbigen and Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate interact with any supplements?
Yes. Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate has documented interactions with 17 supplements in our database — Ascorbigen is not one of them. The Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ascorbic Acid, Polyethylene Glycol 3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, Sodium Sulfate and Ascorbigen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.