Autumn Crocus + Lurbinectedin
Lurbinectedin brand name: Zepzelca.
We found no known interaction between Autumn Crocus and Lurbinectedin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Autumn Crocus and Lurbinectedin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lurbinectedin and Autumn Crocus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Autumn Crocus safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Lurbinectedin
Interactions in our licensed database are recorded against drug classes, not just single drug names. Lurbinectedin is filed under 3 classifications — alkylating agents, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Autumn Crocus has documented interactions with 1 drug class — the most serious being colchicine (major) — and none of Lurbinectedin’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Autumn Crocus Does Interact With Other Medications
Autumn Crocus has 2 major, known drug interactions in our database — Lurbinectedin isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Autumn Crocus
We haven’t checked that one against Autumn Crocus yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Autumn Crocus. Pick one to open its full report.
Autumn Crocus in Pregnancy & Breastfeeding
When used orally. Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Lurbinectedin
This page covers Autumn Crocus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lurbinectedin page lists 156 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Grapefruit (major), Siberian Cocklebur (major), St. John's Wort (major) and Wine (major).
By severity: 5 major · 122 moderate · 29 minor.
From our pharmacist’s overview on the Lurbinectedin page
“Lurbinectedin (Zepzelca) is chemotherapy for small cell lung cancer, and with a drug this potent the 156 supplement interactions on file warrant real attention. Five carry a major rating, and those are the ones to understand first.”
Reviewed by 2 · Jul 18, 2026
Taking Autumn Crocus as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Autumn Crocus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Autumn Crocus. Even though Autumn Crocus itself has no known interaction with Lurbinectedin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Autumn Crocus and Lurbinectedin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,266 of 1,452 supplements looked up here in the last 7 days
#2,291 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Autumn Crocus reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Autumn Crocus and Lurbinectedin records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Autumn Crocus
What is Autumn Crocus?
- Gout
- Familial Mediterranean fever
- Joint pain and inflammation
- Rheumatoid arthritis (traditional use)
Autumn Crocus is a highly poisonous plant that contains colchicine, a compound that has real medical value but is dangerous in its raw form. You should never eat the plant or take homemade preparations from it. If you need colchicine for gout or familial Mediterranean fever, use the standardized, FDA-approved prescription product under a doctor's supervision.
Colchicum autumnale · Colchicaceae · Corm (bulb-like underground stem), seeds, and flowers · Rarely used as a raw plant or crude extract; the purified active compound (colchicine) is available only as an FDA-approved prescription medicine
An interaction check asks whether these two react with each other — it does not ask whether Autumn Crocus is a good idea for someone in your situation. Here is what our Autumn Crocus record says about it on its own.
Autumn Crocus: dosing
There is no safe established dose of the Autumn Crocus plant as a supplement, and it should not be taken in any homemade form. The colchicine content of the plant cannot be reliably measured, so even small amounts can cause serious harm.The only appropriate way to use colchicine is through an FDA-approved prescription product, which has a precise, controlled dose set by your healthcare provider.
From our Autumn Crocus monograph — the full record covers uses, side effects and every documented interaction.
About Lurbinectedin Injection
What Is Lurbinectedin Injection Used For?
Brand name: Zepzelca
Zepzelca (lurbinectedin) injection is approved for adults with small cell lung cancer (SCLC) in two settings. First, Zepzelca is used in combination with atezolizumab (or atezolizumab and hyaluronidase-tqjs) as maintenance treatment for extensive-stage small cell lung cancer (ES-SCLC) in patients whose disease did not progress after initial treatment with those same immunotherapy drugs plus carboplatin and etoposide.
Second, Zepzelca is approved as a single agent for adults with metastatic small cell lung cancer whose cancer has worsened during or after platinum-based chemotherapy. This second use was granted accelerated approval based on tumor response rates, and continued approval depends on results from confirmatory clinical trials.
Other Drugs & Autumn Crocus
Browse every other medication we’ve checked against Autumn Crocus — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Autumn Crocus against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Autumn Crocus list.
Autumn Crocus References
The 9 references that drive our Autumn Crocus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
- Kritikos A, Spertini O. Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale. Blood 2017;130(1):95. doi: 10.1182/blood-2017-02-766410. PubMed
- Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
- Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
- Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
- Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.
- Razinger G, Kozelj G, Gorjup V, Grenc D, Brvar M. Accidental poisoning with autumn crocus (Colchicum autumnale): a case series. Clin Toxicol (Phila). 2021 Jun;59(6):493-9.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Lurbinectedin Is Linked to Lower Levels of One Nutrient
Natural Medicines records Lurbinectedin as a medicine that can lower these. This is not an interaction with Autumn Crocus — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Lurbinectedin nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Autumn Crocus and Lurbinectedin Together: Common Questions
Is it safe to take Autumn Crocus with Lurbinectedin?
Do Autumn Crocus and Lurbinectedin have any of the same side effects?
How was the Autumn Crocus and Lurbinectedin combination checked?
Does Autumn Crocus interact with any other medications?
Does Lurbinectedin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.