Medication interaction hub

What Supplements Interact with Lurbinectedin?

Lurbinectedin brand name: Zepzelca. Every interaction below applies to the brands too.

156 Interactions 5 Major 122 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lurbinectedin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lurbinectedin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Lurbinectedin (Zepzelca) is chemotherapy for small cell lung cancer, and with a drug this potent the 156 supplement interactions on file warrant real attention. Five carry a major rating, and those are the ones to understand first. Most of the list, 121 ingredients, involves the liver enzyme CYP3A4 that clears lurbinectedin from the body. Grapefruit can block that enzyme and push drug levels higher, while St. John's wort speeds it up and can drain the drug's effect. Either direction is a bad outcome during cancer treatment.

A second group of 38 ingredients, ashwagandha and alcohol among them, can stress the liver on top of what chemotherapy already asks of it. A smaller cluster of seven antioxidant products might, in theory, blunt the chemotherapy itself. Of the 156 entries, 122 are moderate and 29 minor, so most call for a conversation with your oncology team rather than alarm, but nothing here should be added quietly.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 122 Minor 29 No known interaction 1,296

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Lurbinectedin: Top Interactions at a Glance

The Lurbinectedin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 156 interacting ingredients — plus 1,296 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Lurbinectedin Combinations Today

The Lurbinectedin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Coenzyme Q10 + Lurbinectedini

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Acerola + Lurbinectedini

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Ligandrol + Lurbinectedini

Theoretically, concomitant use might have additive hepatotoxic effects.

Read the full interaction Moderate Likelihood Possible Calamus + Lurbinectedini

Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Lurbinectedini

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible American Elder + Lurbinectedini

Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Lurbinectedin

All 1,452 ingredients in our database, ranked by severity — 156 with a Lurbinectedin interaction on file and 1,296 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lurbinectedin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coenzyme Q10 with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Lurbinectedin answer

Can you take Acerola with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Lurbinectedin answer

Can you take Ligandrol with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Lurbinectedin answer

Can you take Calamus with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Lurbinectedin answer

Can you take Grapefruit with Lurbinectedin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Lurbinectedin answer

Can you take Chanca Piedra with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Lurbinectedin answer

Can you take Chaparral with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Lurbinectedin answer

Can you take Chokeberry with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Lurbinectedin answer

Can you take Clove with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Lurbinectedin answer

Can you take Coleus with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Lurbinectedin answer

Can you take Comfrey with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Lurbinectedin answer

Can you take Corydalis Yanhusuo with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Lurbinectedin answer

Can you take Cranberry with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Lurbinectedin answer

Can you take Cubebs with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Lurbinectedin answer

Can you take Danshen with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Lurbinectedin answer

Can you take Devil's Claw with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Lurbinectedin answer

Can you take Dhea with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Lurbinectedin answer

Can you take Diosmin with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Lurbinectedin answer

Can you take Echinacea with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Lurbinectedin answer

Can you take Ephedra with Lurbinectedin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Lurbinectedin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lurbinectedin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lurbinectedin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lurbinectedin sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Lurbinectedin through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Lurbinectedin through this category.

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Lurbinectedin through this category.

About Lurbinectedin

Lurbinectedin injection (Zepzelca) is a chemotherapy used to treat small cell lung cancer, either as a maintenance therapy in extensive-stage disease or after prior platinum-based chemotherapy in metastatic disease.

Generic name: Lurbinectedin  ·  Brand name: Zepzelca.

See the full Lurbinectedin Injection drug information

Related: does Lurbinectedin deplete any nutrients?

Lurbinectedin has 1 reported nutrient association in the research literature — see the Lurbinectedin nutrient depletion report.

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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lurbinectedin.

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Pharmacist Counseling Corner

Lurbinectedin & Supplements: Common Questions

What supplements interact with Lurbinectedin?
In our interaction database, 156 supplement and herbal ingredients have an interaction with Lurbinectedin on file — 5 rated major, 122 moderate, and 29 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Beer.
Which Lurbinectedin supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Beer, St. John's Wort and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lurbinectedin?
That depends entirely on which supplement. The honest answer for Lurbinectedin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zepzelca have the same supplement interactions as Lurbinectedin?
Yes — Zepzelca all contain Lurbinectedin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Lurbinectedin deplete any vitamins or nutrients?
It might — Lurbinectedin has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Lurbinectedin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Lurbinectedin and my other medications?
This page covers Lurbinectedin against supplements and herbal ingredients. Checking Lurbinectedin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lurbinectedin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.