Drug & supplement interaction

Lactobacillus Johnsonii + Lurbinectedin

Lurbinectedin brand name: Zepzelca.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lactobacillus Johnsonii and Lurbinectedin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lactobacillus Johnsonii and Lurbinectedin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lurbinectedin and Lactobacillus Johnsonii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactobacillus Johnsonii safety at a glance

Lactobacillus John... overall Use caution Generally well tolerated in healthy adults, but people who are seriously ill or immune-compromised should be cautious.
Pregnancy Use caution There is not enough reliable safety data, so use only with a doctor's guidance.
Breastfeeding Use caution Safety has not been well studied, so check with a healthcare provider before using.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lurbinectedin and Lactobacillus Johnsonii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lurbinectedin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lurbinectedin is filed under 3 classifications — alkylating agents, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Lactobacillus Johnsonii has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Lurbinectedin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactobacillus Johnsonii Does Interact With Other Medications

Lactobacillus Johnsonii has 182 moderate known drug interactions in our database — Lurbinectedin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Lurbinectedin)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Johnsonii

Covers the 2,830 medications we’ve checked against Lactobacillus Johnsonii. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lactobacillus Johnsonii and Lurbinectedin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Lactobacillus Johnsonii

    “Since Lactobacillus johnsonii preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Some lactobacilli species have been isolated in cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis.”

    Lactobacillus Johnsonii · Natural Medicines adverse-effect record, reported in sepsis.

    1 source cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

    Lurbinectedin

    Listed in the ADVERSE REACTIONS section of the FDA label for Lurbinectedin. Read the label on DailyMed ›

Effects for Lurbinectedin come from the ADVERSE REACTIONS section of its FDA label; effects for Lactobacillus Johnsonii come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Lurbinectedin

This page covers Lactobacillus Johnsonii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lurbinectedin page lists 156 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Grapefruit (major), Siberian Cocklebur (major), St. John's Wort (major) and Wine (major).

By severity: 5 major · 122 moderate · 29 minor.

From our pharmacist’s overview on the Lurbinectedin page

“Lurbinectedin (Zepzelca) is chemotherapy for small cell lung cancer, and with a drug this potent the 156 supplement interactions on file warrant real attention. Five carry a major rating, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Lurbinectedin interaction page

One more smart check

Taking Lactobacillus Johnsonii as Part of a Dietary Supplement Product? Check It for Interactions

We hold 17 real supplement products containing Lactobacillus Johnsonii, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Johnsonii. Even though Lactobacillus Johnsonii itself has no known interaction with Lurbinectedin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Johnsonii and Lurbinectedin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Johnsonii
Steady interest

#1,192 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lurbinectedin
Steady interest

#2,274 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactobacillus Johnsonii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lactobacillus Johnsonii and Lurbinectedin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lactobacillus Johnsonii

What is Lactobacillus Johnsonii?

  • Digestive and gut health
  • Supporting healthy gut bacteria
  • Diarrhea prevention or relief
  • Immune support
  • Helping with stomach (H. pylori) discomfort

Lactobacillus johnsonii is a probiotic bacterium found naturally in the human gut and in some fermented foods, and it is used mainly for digestive and immune support. Human evidence for most specific health claims is still limited, so its benefits are uncertain. It is generally well tolerated in healthy people, but anyone with a weakened immune system, serious illness, or who is pregnant should talk to a pharmacist or doctor first.

Lactobacillus johnsonii · Lactobacillaceae · Whole live bacteria (probiotic culture) · Capsules, tablets, powders, and fermented foods or dairy products containing the live culture

An interaction check asks whether these two react with each other — it does not ask whether Lactobacillus Johnsonii is a good idea for someone in your situation. Here is what our Lactobacillus Johnsonii record says about it on its own.

Lactobacillus Johnsonii: dosing

There is no official standardized dose for Lactobacillus johnsonii. Probiotic amounts are usually measured in colony-forming units (CFUs), and products vary widely.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Lactobacillus Johnsonii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactobacillus Johnsonii monograph & all interactions
Medication

About Lurbinectedin Injection

What Is Lurbinectedin Injection Used For?

Brand name: Zepzelca

Zepzelca (lurbinectedin) injection is approved for adults with small cell lung cancer (SCLC) in two settings. First, Zepzelca is used in combination with atezolizumab (or atezolizumab and hyaluronidase-tqjs) as maintenance treatment for extensive-stage small cell lung cancer (ES-SCLC) in patients whose disease did not progress after initial treatment with those same immunotherapy drugs plus carboplatin and etoposide.

Second, Zepzelca is approved as a single agent for adults with metastatic small cell lung cancer whose cancer has worsened during or after platinum-based chemotherapy. This second use was granted accelerated approval based on tumor response rates, and continued approval depends on results from confirmatory clinical trials.

See full Lurbinectedin Injection drug information
Keep checking

Other Drugs & Lactobacillus Johnsonii

Browse every other medication we’ve checked against Lactobacillus Johnsonii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactobacillus Johnsonii page.

No interaction 2,647 drugs checked — show the list

We also checked Lactobacillus Johnsonii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Lactobacillus Johnsonii list.

See the full Lactobacillus Johnsonii interactions page
See every supplement checked against Lurbinectedin, ranked by severity
Evidence & sources

Lactobacillus Johnsonii References

The 2 references that drive our Lactobacillus Johnsonii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactobacillus Johnsonii and Lurbinectedin Together: Common Questions

Is it safe to take Lactobacillus Johnsonii with Lurbinectedin?
We do not list a known interaction between Lactobacillus Johnsonii and Lurbinectedin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lactobacillus Johnsonii and Lurbinectedin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Lactobacillus Johnsonii and Lurbinectedin combination checked?
Interactions in our licensed database are recorded against drug classes. Lurbinectedin is filed under 3 classifications, and Lactobacillus Johnsonii has documented interactions with 1 drug class — none of Lurbinectedin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lactobacillus Johnsonii interact with any other medications?
Yes. Lactobacillus Johnsonii has 182 documented drug interactions in our database — Lurbinectedin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lurbinectedin interact with any supplements?
Yes. Lurbinectedin has documented interactions with 156 supplements in our database — Lactobacillus Johnsonii is not one of them. The Lurbinectedin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lactobacillus Johnsonii monograph Uses, safety profile, and every drug interaction in one place Lurbinectedin Injection drug information The full plain-English guide to this medication Lurbinectedin supplement interactions Every supplement checked against Lurbinectedin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lurbinectedin and Lactobacillus Johnsonii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.