Drug & supplement interaction

Autumn Crocus + Ribavirin Aerosol

Ribavirin Aerosol brand name: Virazole.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Autumn Crocus and Ribavirin Aerosol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ribavirin Aerosol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Autumn Crocus and Ribavirin Aerosol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ribavirin Aerosol and Autumn Crocus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Autumn Crocus safety at a glance

Autumn Crocus overall Avoid The raw plant is poisonous and can cause fatal colchicine poisoning.
Pregnancy Unsafe When used orally. Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ribavirin Aerosol and Autumn Crocus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ribavirin Aerosol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ribavirin Aerosol is filed under a single classification — oral drugs. Autumn Crocus has documented interactions with 1 drug class — the most serious being colchicine (major) — and none of Ribavirin Aerosol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Autumn Crocus Does Interact With Other Medications

Autumn Crocus has 2 major, known drug interactions in our database — Ribavirin Aerosol isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Autumn Crocus

Covers the 2,830 medications we’ve checked against Autumn Crocus. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Autumn Crocus and Ribavirin Aerosol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • Anemia / A low white blood cell count Worth acting on reported in 13.1% of FDA reports for Ribavirin Aerosol Additional detail

    Autumn Crocus

    “Autumn crocus is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Autumn crocus contains colchicine and can cause acute poisoning. Accidental poisoning has occurred after oral ingestion when autumn crocus is mistaken for onions, wild garlic, or wild leeks.”

    Autumn Crocus · Natural Medicines adverse-effect record, reported in anemia.

    3 sources cited
    1. 99057. Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
    2. 99060. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.
    3. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    “Predominant hematologic symptoms of autumn crocus poisoning include pancytopenia, thrombocytopenia, leukopenia or leukocytosis, and coagulopathy. Long-term use of colchicine, a constituent of autumn crocus, is associated with aplastic anemia (6).”

    Autumn Crocus · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 33947. Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
    2. 99056. Kritikos A, Spertini O. Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale. Blood 2017;130(1):95. doi: 10.1182/blood-2017-02-766410. PubMed
    3. 99058. Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
    4. 99059. Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
    5. 99060. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.
    6. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Pancreatitis Worth acting on Additional detail

    Autumn Crocus

    “Gastrointestinal symptoms are often the first signs of autumn crocus poisoning and include burning of the mouth, vomiting, diarrhea, abdominal pain, and ileus. These symptoms typically occur within 2-12 hours after oral ingestion, with early onset indicating a poorer prognosis. Pancreatitis has also been reported with severe autumn crocus poisoning.”

    Autumn Crocus · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 33947. Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
    2. 99056. Kritikos A, Spertini O. Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale. Blood 2017;130(1):95. doi: 10.1182/blood-2017-02-766410. PubMed
    3. 99057. Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
    4. 99058. Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
    5. 99059. Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
    6. 99060. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol. Read the label on DailyMed ›

  • A low platelet count Worth acting on Additional detail

    Autumn Crocus

    Recorded for Autumn Crocus in the same Natural Medicines adverse-effect record shown under Anemia / A low white blood cell count above.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol. Read the label on DailyMed ›

  • Shortness of breath Worth acting on Additional detail

    Autumn Crocus

    “Predominant pulmonary symptoms of autumn crocus poisoning include tachypnea, respiratory distress or failure, and pleural effusions. Some patients require mechanical ventilation or extracorporeal membrane oxygenation (ECMO) for life support.”

    Autumn Crocus · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    5 sources cited
    1. 99057. Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
    2. 99058. Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
    3. 99059. Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
    4. 33947. Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
    5. 99060. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol. Read the label on DailyMed ›

  • Hair loss Additional detail

    Autumn Crocus

    “Alopecia has been reported during the recovery phase from acute oral autumn crocus poisoning, about 7-21 days after oral ingestion.”

    Autumn Crocus · Natural Medicines adverse-effect record, reported in alopecia.

    3 sources cited
    1. 33947. Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
    2. 99057. Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
    3. 99060. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol. Read the label on DailyMed ›

  • Stomach pain / Vomiting / Diarrhea reported in 6.0% of FDA reports for Ribavirin Aerosol Additional detail

    Autumn Crocus

    Recorded for Autumn Crocus in the same Natural Medicines adverse-effect record shown under Pancreatitis above.

    Ribavirin Aerosol

    Listed in the ADVERSE REACTIONS section of the FDA label for Ribavirin Aerosol, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Autumn Crocus but not commonly for Ribavirin Aerosol: numbness or tingling, severe muscle breakdown, kidney problems and low blood sugar.

Effects for Ribavirin Aerosol come from the ADVERSE REACTIONS section of its FDA label; effects for Autumn Crocus come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 63,877 voluntary FDA FAERS reports for Ribavirin Aerosol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Autumn Crocus in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Ribavirin Aerosol Products Have a Food Rule — Autumn Crocus Should Not Break It

At least one FDA label for a product containing Ribavirin Aerosol says to take it with food. If you take Autumn Crocus on an empty stomach out of habit, keep them separate — and take Ribavirin Aerosol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ribavirin Aerosol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Ribavirin capsules should be taken with food [see Clinical Pharmacology (12.3) ].

From the Dosage and Administration section of the FDA label we read for Ribavirin Aerosol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ribavirin Aerosol

This page covers Autumn Crocus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ribavirin Aerosol page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Ribavirin Aerosol page

“Ribavirin Aerosol (Virazole) is an inhaled antiviral used mostly in hospitals against severe RSV infection, and with an infection that serious, losing drug exposure is not a small problem, so I would approach this list with genuine care. Its one major-rated interaction, activated charcoal, can pull ribavirin out of the body even though…”

Reviewed by 2 · Jul 18, 2026

Open the Ribavirin Aerosol interaction page

One more smart check

Taking Autumn Crocus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Autumn Crocus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Autumn Crocus. Even though Autumn Crocus itself has no known interaction with Ribavirin Aerosol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Autumn Crocus and Ribavirin Aerosol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Autumn Crocus
Steady interest

#951 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ribavirin Aerosol
Top 5%

#121 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Autumn Crocus reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Autumn Crocus and Ribavirin Aerosol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Autumn Crocus

What is Autumn Crocus?

Autumn Crocus
  • Gout
  • Familial Mediterranean fever
  • Joint pain and inflammation
  • Rheumatoid arthritis (traditional use)

Autumn Crocus is a highly poisonous plant that contains colchicine, a compound that has real medical value but is dangerous in its raw form. You should never eat the plant or take homemade preparations from it. If you need colchicine for gout or familial Mediterranean fever, use the standardized, FDA-approved prescription product under a doctor's supervision.

Colchicum autumnale · Colchicaceae · Corm (bulb-like underground stem), seeds, and flowers · Rarely used as a raw plant or crude extract; the purified active compound (colchicine) is available only as an FDA-approved prescription medicine

An interaction check asks whether these two react with each other — it does not ask whether Autumn Crocus is a good idea for someone in your situation. Here is what our Autumn Crocus record says about it on its own.

Autumn Crocus: dosing

There is no safe established dose of the Autumn Crocus plant as a supplement, and it should not be taken in any homemade form. The colchicine content of the plant cannot be reliably measured, so even small amounts can cause serious harm.The only appropriate way to use colchicine is through an FDA-approved prescription product, which has a precise, controlled dose set by your healthcare provider.

From our Autumn Crocus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Autumn Crocus monograph & all interactions
Medication

About Ribavirin

What Is Ribavirin Used For?

Brand name: Virazole

Ribavirin comes in different forms for different uses. Ribavirin capsules are used in combination with interferon alfa-2b (pegylated or non-pegylated) to treat chronic hepatitis C (CHC) in patients 3 years and older with compensated liver disease. Ribavirin tablets are used in combination with PEGASYS® (peginterferon alfa-2a) to treat chronic hepatitis C in patients 5 years and older with compensated liver disease who have not previously been treated with interferon — including adults who also have HIV. Ribavirin for inhalation solution is a separate product used to treat hospitalized infants and young children with severe lower respiratory tract infections caused by respiratory syncytial virus (RSV).

Ribavirin must never be used alone to treat hepatitis C — it only works as part of combination therapy. Only the most severe RSV infections requiring hospitalization should be treated with the inhaled form; mild RSV illness in children does not require this treatment.

See full Ribavirin drug information
Keep checking

Other Drugs & Autumn Crocus

Browse every other medication we’ve checked against Autumn Crocus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
0Moderate
0Minor
2,827No known interaction
Major

2 interactions

No interaction 2,827 drugs checked — show the list
Evidence & sources

Autumn Crocus References

The 9 references that drive our Autumn Crocus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Brvar, M., Kozelj, G., Mozina, M., and Bunc, M. Acute poisoning with autumn crocus (Colchicum autumnale L.). Wien.Klin Wochenschr. 3-31-2004;116(5-6):205-208. PubMed
  4. Kritikos A, Spertini O. Reversible granulocyte abnormalities after accidental ingestion of Colchicum autumnale. Blood 2017;130(1):95. doi: 10.1182/blood-2017-02-766410. PubMed
  5. Nagesh KR, Menezes RG, Rastogi P, et al. Suicidal plant poisoning with Colchicum autumnale. J Forensic Leg Med 2011;18(6):285-7. doi: 10.1016/j.jflm.2011.04.008. PubMed
  6. Brncic N, Viskovic I, Peric R, et al. Accidental plant poisoning with Colchicum autumnale: report of two cases. Croat Med J 2001;42(6):673-5.
  7. Sundov Z, Nincevic Z, Definis-Gojanovic M, et al. Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. Forensic Sci Int 2005;149(2-3):253-6. PubMed
  8. Boisramé-Helms J, Rahmani H, Stiel L, Tournoud C, Sauder P. Extracorporeal life support in the treatment of colchicine poisoning. Clin Toxicol (Phila) 2015;53(8):827-9.
  9. Razinger G, Kozelj G, Gorjup V, Grenc D, Brvar M. Accidental poisoning with autumn crocus (Colchicum autumnale): a case series. Clin Toxicol (Phila). 2021 Jun;59(6):493-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Autumn Crocus and Ribavirin Aerosol Together: Common Questions

Is it safe to take Autumn Crocus with Ribavirin Aerosol?
We do not list a known interaction between Autumn Crocus and Ribavirin Aerosol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Autumn Crocus and Ribavirin Aerosol have any of the same side effects?
Yes — our sources link each of them separately to 9 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Autumn Crocus and Ribavirin Aerosol at the same time of day?
At least one FDA label for a product containing Ribavirin Aerosol says to take it with food. If you take Autumn Crocus on an empty stomach out of habit, keep them separate and take Ribavirin Aerosol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ribavirin Aerosol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Autumn Crocus and Ribavirin Aerosol combination checked?
Interactions in our licensed database are recorded against drug classes. Ribavirin Aerosol is filed under 1 classification, and Autumn Crocus has documented interactions with 1 drug class — none of Ribavirin Aerosol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Autumn Crocus interact with any other medications?
Yes. Autumn Crocus has 2 documented drug interactions in our database — Ribavirin Aerosol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ribavirin Aerosol interact with any supplements?
Yes. Ribavirin Aerosol has documented interactions with 17 supplements in our database — Autumn Crocus is not one of them. The Ribavirin Aerosol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ribavirin Aerosol and Autumn Crocus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.