Drug & supplement interaction

Avocado Soy Unsaponifiables (asu) + Hydroxyurea

Hydroxyurea brand names: Droxia, Hydrea, Siklos, Xromi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Avocado Soy Unsaponifiables (asu) and Hydroxyurea in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Avocado Soy Unsaponifiables (asu) and Hydroxyurea

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydroxyurea and Avocado Soy Unsaponifiables (asu) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Avocado Soy Unsaponifiables (asu) at all — not against Hydroxyurea, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Avocado Soy Unsaponifiables (asu) safety at a glance

Avocado Soy Unsapo... overall Use caution Generally well tolerated for short to medium-term use, but long-term safety is not fully established.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding has not been studied, so avoidance is recommended.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydroxyurea and Avocado Soy Unsaponifiables (asu)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Avocado Soy Unsaponifiables (asu) and Hydroxyurea May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation / Diarrhea / Stomach pain / Nausea reported in 6.7% of FDA reports for Hydroxyurea Additional detail

    Avocado Soy Unsaponifiables (asu)

    “Orally, avocado soy unsaponifiables have been rarely reported to cause constipation, diarrhea, dyspepsia, heartburn, nausea, regurgitation, and stomach pain. In addition, a single case of lymphocytic colitis thought to be associated with the use of a specific type of avocado soy unsaponifiables (Piascledine 300, Laboratoires Expanscience) has been reported.”

    Avocado Soy Unsaponifiables (asu) · Natural Medicines adverse-effect record, reported in constipation.

    3 sources cited
    1. 10693. Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month
    2. 10694. Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. PubMed
    3. 100551. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. PubMed

    Hydroxyurea

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydroxyurea, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache reported in 5.1% of FDA reports for Hydroxyurea Additional detail

    Avocado Soy Unsaponifiables (asu)

    “Orally, avocado soy unsaponifiables have been rarely reported to cause drowsiness, headache, and migraine.”

    Avocado Soy Unsaponifiables (asu) · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 10693. Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month

    Hydroxyurea

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydroxyurea, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash Additional detail

    Avocado Soy Unsaponifiables (asu)

    “Orally, avocado soy unsaponifiables have been rarely reported to cause atopic dermatitis and rash.”

    Avocado Soy Unsaponifiables (asu) · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 10693. Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month
    2. 100551. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. PubMed

    Hydroxyurea

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydroxyurea. Read the label on DailyMed ›

Reported for Avocado Soy Unsaponifiables (asu) but not commonly for Hydroxyurea: drowsiness, stomach upset, heartburn and migraine.

Effects for Hydroxyurea come from the ADVERSE REACTIONS section of its FDA label; effects for Avocado Soy Unsaponifiables (asu) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 21,027 voluntary FDA FAERS reports for Hydroxyurea that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Avocado Soy Unsaponifiables (asu) or Hydroxyurea

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Avocado Soy Unsaponifiables (asu) or Hydroxyurea, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydroxyurea

This page covers Avocado Soy Unsaponifiables (asu) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyurea page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 10 minor.

From our pharmacist’s overview on the Hydroxyurea page

“People take hydroxyurea (Droxia, Hydrea, Siklos, Xromi) for serious reasons, most often sickle cell disease or certain blood cancers, and it only works if a steady dose reaches the bloodstream. That is exactly what nearly all 18 supplements listed here can undermine, so this page earns real vigilance rather than a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Hydroxyurea interaction page

How much people look this up

Where Avocado Soy Unsaponifiables (asu) and Hydroxyurea Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Avocado Soy Unsaponifiables (asu)
Steady interest

#944 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydroxyurea
Top 5%

#40 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Avocado Soy Unsaponifiables (asu) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Avocado Soy Unsaponifiables (asu) and Hydroxyurea records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Avocado Soy Unsaponifiables (asu)

What is Avocado Soy Unsaponifiables (asu)?

Avocado Soy Unsaponifiables (asu)
  • Osteoarthritis of the knee and hip
  • Joint pain and stiffness
  • Reducing reliance on NSAIDs
  • Cartilage support
  • Temporomandibular joint (TMJ) discomfort

Avocado Soy Unsaponifiables (ASU) is a plant-oil extract studied mainly for osteoarthritis of the knee and hip, where some research suggests it may modestly ease pain and improve joint function. It is generally well tolerated, but the evidence is mixed and effects build slowly over months. Talk with your pharmacist or doctor before starting, especially if you take other medicines or have allergies.

Oils from avocado fruit (Persea americana) and soybean (Glycine max) · Capsules, softgels (often combined with glucosamine and chondroitin in joint supplements)

An interaction check asks whether these two react with each other — it does not ask whether Avocado Soy Unsaponifiables (asu) is a good idea for someone in your situation. Here is what our Avocado Soy Unsaponifiables (asu) record says about it on its own.

Avocado Soy Unsaponifiables (asu): dosing

There is no official standardized dose for ASU, and products can differ in strength and content. Because ASU works slowly, it may take two to three months before you can judge whether it is helping.

From our Avocado Soy Unsaponifiables (asu) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Avocado Soy Unsaponifiables (asu) monograph & all interactions
Medication

About Hydroxyurea

What Is Hydroxyurea Used For?

Brand names: Droxia, Hydrea, Siklos, Xromi

Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults.

Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.

Most-Reported Side Effects for Hydroxyurea

From FAERS, the FDA’s public side-effect reporting system (21,027 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,548 reports
Sickle cell anaemia with crisis 1,486 reports
Diarrhea 1,408 reports
Nausea 1,306 reports
Headache 1,068 reports
See full Hydroxyurea drug information
Keep checking

Other Drugs & Avocado Soy Unsaponifiables (asu)

Browse every other medication we’ve checked against Avocado Soy Unsaponifiables (asu) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Avocado Soy Unsaponifiables (asu) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Avocado Soy Unsaponifiables (asu) list.

See the full Avocado Soy Unsaponifiables (asu) interactions page
See every supplement checked against Hydroxyurea, ranked by severity
Evidence & sources

Avocado Soy Unsaponifiables (asu) References

The 3 references that drive our Avocado Soy Unsaponifiables (asu) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month
  2. Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. PubMed
  3. Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Avocado Soy Unsaponifiables (asu) and Hydroxyurea Together: Common Questions

Is it safe to take Avocado Soy Unsaponifiables (asu) with Hydroxyurea?
We do not list a known interaction between Avocado Soy Unsaponifiables (asu) and Hydroxyurea. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Avocado Soy Unsaponifiables (asu) and Hydroxyurea have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Hydroxyurea interact with any supplements?
Yes. Hydroxyurea has documented interactions with 18 supplements in our database — Avocado Soy Unsaponifiables (asu) is not one of them. The Hydroxyurea interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Avocado Soy Unsaponifiables (asu) monograph Uses, safety profile, and every drug interaction in one place Hydroxyurea drug information The full plain-English guide to this medication Hydroxyurea supplement interactions Every supplement checked against Hydroxyurea, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydroxyurea and Avocado Soy Unsaponifiables (asu)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.