Banderol - Hydrochlorothiazide, Methyldopa Interaction
Herbal: Banderol
Also Known As: Otoba parvifolia
Drug: Hydrochlorothiazide, Methyldopa
Brand names:
Aldoril 15, Methazide, Aldoril 25, Aldoril D30
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 11, 2023
Interaction Details
Hydrochlorothiazide, Methyldopa is classified as belonging to the following category: Organic Anion Transporter 1 (Oat1) Substrates
Small lab studies have found that Banderol may inhibit OATP1B1 (Organic Anion Transporting Polypeptide 1B1), which is a membrane protein responsible for the uptake of various drugs, hormones, and other biologically active substances into the cells of the liver and other tissues. It is often referred to as a drug transporter. It is a member of the OATP family of transporters and is known to play a critical role in the pharmacokinetics of many drugs. When OATPs are inhibited, it can cause problems with the elimination of drugs and result in a sudden rise in the concentration of the drug in the bloodstream and the extent to which it is absorbed (AUC) for drugs that rely on these transporters. This can increase the likelihood of adverse side effects associated with the therapy.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Interaction Details
Hydrochlorothiazide, Methyldopa is classified as belonging to the following category: Organic Anion Transporter 3 (Oat3) Substrates
Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1. If a drug is a substrate for both transporters, the risk of interaction with Banderol increases but the overall clinical significance is not well understood.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Banderol Overview
Banderol is a dietary supplement manufactured by Nutramedix. It contains Otoba parvifolia bark extract. Otoba parvifolia is a species of tree in the Myristicaceae family, which is native to the Amazonian region of South America. It is also known as the "Small-leaved Otoba".
It is believed that the leaves and bark of the Otoba parvifolia tree have medicinal properties, such as anti-inflammatory properties that may help to reduce pain, swelling, and redness in the body. Additionally, the bark is thought to have antimicrobial properties, which may be effective against bacteria and fungi, including some that are resistant to antibiotics.
Banderol - More Interactions
Banderol interacts with 173 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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