Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Methyldopa?

Hydrochlorothiazide, Methyldopa brand names: Aldoril 15, Methazide, Aldoril 25, Aldoril D30. Every interaction below applies to the brands too.

261 Interactions 13 Major 223 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Methyldopa? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Methyldopa against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take hydrochlorothiazide with methyldopa (Aldoril, Methazide), this list deserves real attention, and the 13 major-rated entries are where to start. Most of the 261 ingredients either push blood pressure lower than intended or add to the diuretic effect, which can drain potassium. A smaller cluster, including wine and beer, adds strain on the liver, a known concern with methyldopa. Calcium, including the supplement dolomite, works differently. Thiazides hold calcium in the body, so adding more raises the risk of high calcium and kidney damage.

The other 223 moderate and 25 minor entries mostly repeat those same patterns: added blood pressure lowering, added potassium loss, or extra sun sensitivity from the 20 photosensitizing entries. If any of the thirteen majors is something you use, ask your pharmacist before continuing it. Keep activated charcoal well apart from your doses too, since it can soak up the medicine before your body absorbs it.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 223 Minor 25 No known interaction 1,191

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Hydrochlorothiazide, Methyldopa: Top Interactions at a Glance

The most significant Hydrochlorothiazide, Methyldopa supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 261 interacting ingredients — plus 1,191 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Hydrochlorothiazide, Methyldopa + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Hydrochlorothiazide, Methyldopai

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydrochlorothiazide, Methyldopai

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Likely Tyramine + Hydrochlorothiazide, Methyldopai

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Hydrochlorothiazide, Methyldopai

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Hydrochlorothiazide, Methyldopai

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Beer + Hydrochlorothiazide, Methyldopai

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Methyldopa

All 1,452 ingredients in our database, ranked by severity — 261 with a Hydrochlorothiazide, Methyldopa interaction on file and 1,191 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Methyldopa?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin D with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.

Full Vitamin D + Hydrochlorothiazide, Methyldopa answer

Can you take Saffron with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.

Full Saffron + Hydrochlorothiazide, Methyldopa answer

Can you take Sage with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase or decrease the effects of antihypertensive drugs.

Full Sage + Hydrochlorothiazide, Methyldopa answer

Can you take Saigon Cinnamon with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Hydrochlorothiazide, Methyldopa answer

Can you take Sea Buckthorn with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Hydrochlorothiazide, Methyldopa answer

Can you take Senna with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Hydrochlorothiazide, Methyldopa answer

Can you take Slippery Elm with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Hydrochlorothiazide, Methyldopa answer

Can you take Sodium Bicarbonate with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Hydrochlorothiazide, Methyldopa answer

Can you take Soy with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Hydrochlorothiazide, Methyldopa answer

Can you take Spearmint with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Hydrochlorothiazide, Methyldopa answer

Can you take Squill with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Hydrochlorothiazide, Methyldopa answer

Can you take St. John's Wort with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Hydrochlorothiazide, Methyldopa answer

Can you take Star Of Bethlehem with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Hydrochlorothiazide, Methyldopa answer

Can you take Stinging Nettle with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Hydrochlorothiazide, Methyldopa answer

Can you take Strophanthus with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Hydrochlorothiazide, Methyldopa answer

Can you take Swamp Milkweed with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Hydrochlorothiazide, Methyldopa answer

Can you take Sweet Annie with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Hydrochlorothiazide, Methyldopa answer

Can you take Sweet Clover with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Hydrochlorothiazide, Methyldopa answer

Can you take Syrian Rue with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Hydrochlorothiazide, Methyldopa answer

Can you take Testolone with Hydrochlorothiazide, Methyldopa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Hydrochlorothiazide, Methyldopa answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Methyldopa is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Methyldopa, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Methyldopa sits in 11 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Methyldopa (Aldomet) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Hydrochlorothiazide, Methyldopa through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrochlorothiazide, Methyldopa through this category.

Related: does Hydrochlorothiazide, Methyldopa deplete any nutrients?

Hydrochlorothiazide, Methyldopa has 36 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Methyldopa nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Methyldopa

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Methyldopa.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Methyldopa & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Methyldopa?
More than you might expect — 261 in total, though they are far from equal: 13 are rated major, 223 moderate, and 25 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Methyldopa supplement interactions are the most serious?
The 13 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Methyldopa?
Usually yes — most people on Hydrochlorothiazide, Methyldopa can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Aldoril 15 have the same supplement interactions as Hydrochlorothiazide, Methyldopa?
Yes — Aldoril 15, Methazide, Aldoril 25, Aldoril D30 all contain Hydrochlorothiazide, Methyldopa, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Methyldopa deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Methyldopa has 36 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Methyldopa nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Methyldopa and my other medications?
This page covers Hydrochlorothiazide, Methyldopa against supplements and herbal ingredients. Checking Hydrochlorothiazide, Methyldopa against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.