Drug & supplement interaction

Samphire + Hydrochlorothiazide, Methyldopa

Hydrochlorothiazide, Methyldopa brand names: Aldoril 15, Methazide, Aldoril 25, Aldoril D30.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Samphire and Hydrochlorothiazide, Methyldopa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Samphire and Hydrochlorothiazide, Methyldopa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide, Methyldopa and Samphire in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Samphire at all — not against Hydrochlorothiazide, Methyldopa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Samphire safety at a glance

Samphire overall Use caution Generally safe as a food, but it can be high in sodium and is poorly studied as a supplement.
Pregnancy Use caution Likely fine in normal food amounts, but avoid concentrated supplements due to lack of safety data.
Breastfeeding Use caution Food amounts are probably okay, but supplement-strength products have not been studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide, Methyldopa and Samphire? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Methyldopa

This page covers Samphire only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Methyldopa page lists 261 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Beer (major).

By severity: 13 major · 223 moderate · 25 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Methyldopa page

“If you take hydrochlorothiazide with methyldopa (Aldoril, Methazide), this list deserves real attention, and the 13 major-rated entries are where to start. Most of the 261 ingredients either push blood pressure lower than intended or add to the diuretic effect, which can drain potassium.”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Methyldopa interaction page

One more smart check

Taking Samphire as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Samphire, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Samphire. Even though Samphire itself has no known interaction with Hydrochlorothiazide, Methyldopa, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Samphire and Hydrochlorothiazide, Methyldopa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Samphire
Top half

#724 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Methyldopa
Top 25%

#290 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Samphire is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Samphire reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Samphire and Hydrochlorothiazide, Methyldopa records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Samphire

What is Samphire?

  • Culinary vegetable and seasoning
  • Source of vitamins and minerals
  • Digestive health
  • Traditional skin and antioxidant uses
  • Salt substitute or low-sodium flavoring

Samphire is a salt-tolerant coastal plant eaten as a vegetable, prized for its crisp, salty taste and its nutrients like vitamins and minerals. There is very little human research supporting any specific health benefit beyond its value as a food, so it should be enjoyed mainly as a food rather than relied on as a medicine. If you are pregnant, breastfeeding, or watching your salt intake, talk to a pharmacist or doctor first.

Young stems and leaves (sometimes the whole above-ground plant) · Fresh vegetable, pickled, dried, powder, and occasionally as an extract

An interaction check asks whether these two react with each other — it does not ask whether Samphire is a good idea for someone in your situation. Here is what our Samphire record says about it on its own.

Samphire: dosing

There is no established medicinal dose for samphire. As a food, people simply eat it as a vegetable in normal portions.

From our Samphire monograph — the full record covers uses, side effects and every documented interaction.

Read the full Samphire monograph & all interactions
Keep checking

Other Drugs & Samphire

Browse every other medication we’ve checked against Samphire — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Samphire against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Samphire list.

See the full Samphire interactions page
See every supplement checked against Hydrochlorothiazide, Methyldopa, ranked by severity
Evidence & sources

Samphire References

The 3 sources that drive our Samphire monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Samphire is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Sodium in Your Diet — U.S. Food and Drug Administration (FDA) Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Herbal Supplements — MedlinePlus (NIH) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Samphire and Hydrochlorothiazide, Methyldopa Together: Common Questions

Is it safe to take Samphire with Hydrochlorothiazide, Methyldopa?
We do not list a known interaction between Samphire and Hydrochlorothiazide, Methyldopa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Hydrochlorothiazide, Methyldopa interact with any supplements?
Yes. Hydrochlorothiazide, Methyldopa has documented interactions with 261 supplements in our database — Samphire is not one of them. The Hydrochlorothiazide, Methyldopa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Samphire monograph Uses, safety profile, and every drug interaction in one place Hydrochlorothiazide, Methyldopa supplement interactions Every supplement checked against Hydrochlorothiazide, Methyldopa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide, Methyldopa and Samphire?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.