Horny Goat Weed - Hydrochlorothiazide, Methyldopa Interaction
Herbal: Horny Goat Weed
Also Known As: Epimedium grandiflorum, Barrenwort, Épimède, Épimède à Grandes Fleurs, Épimède du Japon, Epimedium, Epimedium Grandiflorum Radix, Herba Epimedii, Herbe Cornée de Chèvre, Hierba de Cabra en Celo, Japanese Epimedium, Xian Ling Pi, Yin Yang Huo
Drug: Hydrochlorothiazide, Methyldopa
Brand names:
Aldoril 15, Methazide, Aldoril 25, Aldoril D30
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 27, 2025
Interaction Details
Hydrochlorothiazide, Methyldopa is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
Horny Goat Weed Overview
Horny goat weed, also known as epimedium, is a plant native to Asia and a member of the Berberidaceae family. It is known for its small, purple flowers and heart-shaped leaves.
In traditional medicine, horny goat weed is thought to have anti-inflammatory and pain-relieving effects, and it has been used to treat a variety of conditions, including digestive problems, respiratory infections, and skin disorders.
Horny goat weed is also commonly used as a natural treatment for male infertility and as a natural performance-enhancing supplement as it may have a mild androgenic effect.
Horny Goat Weed - More Interactions
Horny Goat Weed interacts with 939 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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