Drug & supplement interaction

Black Horehound + Sufentanil Citrate

Sufentanil Citrate brand name: Dsuvia.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Black Horehound and Sufentanil Citrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Horehound and Sufentanil Citrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sufentanil Citrate and Black Horehound in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Horehound safety at a glance

Black Horehound overall Use caution Limited safety data exist, so use cautiously and talk to a pharmacist first.

Pregnancy Likely Unsafe When used orally; black horehound may affect the menstrual cycle. There is insufficient reliable information available about the safety of black horehound used... Read the full pregnancy detail

Breastfeeding Avoid Safety is unknown, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sufentanil Citrate and Black Horehound? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Sufentanil Citrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sufentanil Citrate is filed under 3 classifications — cns depressants, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Black Horehound has documented interactions with 1 drug class — the most serious being dopamine agonists (moderate) — and none of Sufentanil Citrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Horehound Does Interact With Other Medications

Black Horehound has 23 moderate known drug interactions in our database — Sufentanil Citrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 23 No known interaction 2,807 (incl. Sufentanil Citrate)

Taking anything else?

Check Another of Your Medications Against Black Horehound

Covers the 2,830 medications we’ve checked against Black Horehound. Pick one to open its full report.

Special populations

Black Horehound in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; black horehound may affect the menstrual cycle. There is insufficient reliable information available about the safety of black horehound used topically or rectally during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sufentanil Citrate

This page covers Black Horehound only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sufentanil Citrate page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Sufentanil Citrate page

“Anything sedating is the first hazard to understand with sufentanil citrate (Dsuvia), an opioid so potent that stacking another depressant on top can slow breathing, not just cause grogginess. Alcohol sits among the nine major-rated entries here, and those nine are worth learning before you look at the rest of the page.”

Reviewed by 2 · Jul 18, 2026

Open the Sufentanil Citrate interaction page

How much people look this up

Where Black Horehound and Sufentanil Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Horehound

Steady interest

#898 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Sufentanil Citrate

Steady interest

#2,478 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Horehound reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Horehound and Sufentanil Citrate records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Black Horehound

What is Black Horehound?

Nausea and vomiting
Anxiety and nervous tension
Sleep problems
Mild digestive upset
Coughs and respiratory complaints

Black horehound is a traditional European herb mainly used for nausea, mild anxiety, and digestive upset, but high-quality human studies are lacking, so its effectiveness is largely unproven. It has a strong, unpleasant smell and taste, and its safety has not been well studied, so it should be avoided in pregnancy and breastfeeding and used cautiously by everyone else.

Ballota nigra · Lamiaceae · Above-ground parts (flowering tops and leaves) · Tea (infusion), liquid extract, tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Black Horehound is a good idea for someone in your situation. Here is what our Black Horehound record says about it on its own.

Black Horehound: dosing

There is no well-established, standardized dose for black horehound. Traditional use has involved teas made from the dried herb and liquid extracts or tinctures, but reliable dosing from quality human studies is not available.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Black Horehound monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Horehound monograph & all interactions

Medication

About Sufentanil Citrate

Most-Reported Side Effects for Sufentanil Citrate

From FAERS, the FDA’s public side-effect reporting system (1,247 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Anaphylactic shock 229 reports

Hypotension 132 reports

Anaphylactic reaction 79 reports

Renal failure 74 reports

Bronchospasm 70 reports

Keep checking

Other Drugs & Black Horehound

Browse every other medication we’ve checked against Black Horehound — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

23Moderate

0Minor

2,806No known interaction

23 Moderate 2,806 No interaction

Moderate

23 interactions

No interaction 2,806 drugs checked — show the list

We also checked Black Horehound against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,806 medications checked with no known interaction — see the full Black Horehound list.

See the full Black Horehound interactions page

See every supplement checked against Sufentanil Citrate, ranked by severity

Evidence & sources

Black Horehound References

The 2 references that drive our Black Horehound monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Daels-Rakotoarison DA, Seidel V, Gressier B, et al. Neurosedative and antioxidant activities of phenylpropanoids from Ballota nigra. Arzneimittelforschung 2000;50:16-23. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Horehound and Sufentanil Citrate Together: Common Questions

Is it safe to take Black Horehound with Sufentanil Citrate?

We do not list a known interaction between Black Horehound and Sufentanil Citrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Black Horehound and Sufentanil Citrate combination checked?

Interactions in our licensed database are recorded against drug classes. Sufentanil Citrate is filed under 3 classifications, and Black Horehound has documented interactions with 1 drug class — none of Sufentanil Citrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Black Horehound interact with any other medications?

Yes. Black Horehound has 23 documented drug interactions in our database — Sufentanil Citrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Sufentanil Citrate interact with any supplements?

Yes. Sufentanil Citrate has documented interactions with 195 supplements in our database — Black Horehound is not one of them. The Sufentanil Citrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Horehound monograph Uses, safety profile, and every drug interaction in one place Sufentanil Citrate supplement interactions Every supplement checked against Sufentanil Citrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sufentanil Citrate and Black Horehound?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.