Drug & supplement interaction

Black Mustard + Misoprostol

Misoprostol brand name: Cytotec.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Mustard and Misoprostol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Misoprostol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Black Mustard and Misoprostol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Misoprostol and Black Mustard in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Mustard safety at a glance

Black Mustard overall Use caution Generally safe as a food spice, but concentrated seeds or oil can irritate the skin and digestive tract.
Pregnancy Likely Unsafe When used orally for medicinal purposes. Black mustard might have abortifacient and menstrual stimulant effects. There is insufficient reliable information avai... Read the full pregnancy detail
Breastfeeding Use caution Food amounts are likely fine, but there is not enough safety data on medicinal use, so caution is advised.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Misoprostol and Black Mustard? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Misoprostol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Misoprostol is filed under a single classification — oral drugs. Black Mustard has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Misoprostol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Black Mustard Does Interact With Other Medications

Black Mustard has 86 moderate known drug interactions in our database — Misoprostol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Misoprostol)
Taking anything else?

Check Another of Your Medications Against Black Mustard

Covers the 2,830 medications we’ve checked against Black Mustard. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Black Mustard and Misoprostol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Black Mustard

    “Orally, taking very large amounts of black mustard seed can lead to breathing difficulties and possibly death (18). In a case report, a 15 month-old male developed acute, severe respiratory distress after ingesting and aspirating ground black mustard seeds.”

    Black Mustard · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 64387. Gulbransen, G. and Esernio-Jenssen, D. Aspiration of black mustard. J Toxicol.Clin.Toxicol. 1998;36(6):591-593. PubMed

    Misoprostol

    Listed in the ADVERSE REACTIONS section of the FDA label for Misoprostol. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting Additional detail

    Black Mustard

    “Orally, taking very large amounts of black mustard seed can lead to vomiting, stomach pain, and diarrhea (18).”

    Black Mustard · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Misoprostol

    Listed in the ADVERSE REACTIONS section of the FDA label for Misoprostol. Read the label on DailyMed ›

Effects for Misoprostol come from the ADVERSE REACTIONS section of its FDA label; effects for Black Mustard come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 16,478 voluntary FDA FAERS reports for Misoprostol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Black Mustard in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally for medicinal purposes. Black mustard might have abortifacient and menstrual stimulant effects. There is insufficient reliable information available about the safety of black mustard for its other uses during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Misoprostol Products Have a Food Rule — Black Mustard Should Not Break It

At least one FDA label for a product containing Misoprostol says to take it with food. If you take Black Mustard on an empty stomach out of habit, keep them separate — and take Misoprostol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Misoprostol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The recommended adult oral dose of Cytotec for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily with food.

From the Dosage and Administration section of the FDA label we read for Misoprostol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Misoprostol

This page covers Black Mustard only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Misoprostol page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Misoprostol page

“Misoprostol (Cytotec) is taken by mouth to protect the stomach lining from ulcers caused by NSAID pain relievers, and all 17 of its recorded supplement interactions come down to the same problem, something in the gut keeping the pill from being absorbed properly. That deserves genuine wariness, because misoprostol that never reaches th…”

Reviewed by 2 · Jul 18, 2026

Open the Misoprostol interaction page

One more smart check

Taking Black Mustard as Part of a Dietary Supplement Product? Check It for Interactions

We hold 77 real supplement products containing Black Mustard, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Mustard. Even though Black Mustard itself has no known interaction with Misoprostol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Mustard and Misoprostol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Mustard
Top half

#525 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Misoprostol
Steady interest

#1,703 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Mustard reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Mustard and Misoprostol records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Mustard

What is Black Mustard?

Black Mustard
  • Culinary spice
  • Muscle and joint aches (topical plaster)
  • Chest congestion (chest rub or poultice)
  • Digestive upset
  • Antioxidant and anti-inflammatory support

Black mustard is best known as a pungent culinary spice and a traditional topical remedy for muscle aches and congestion. Solid human evidence for any specific health benefit is limited, and concentrated seed extracts or undiluted oil can irritate or burn the skin. Use it mainly as a food, and talk to a pharmacist or doctor before using it medicinally.

Brassica nigra · Brassicaceae · Seeds and seed oil; sometimes leaves · Whole or ground seeds (spice), mustard oil, poultices/plasters, powder

An interaction check asks whether these two react with each other — it does not ask whether Black Mustard is a good idea for someone in your situation. Here is what our Black Mustard record says about it on its own.

Black Mustard: dosing

There is no well-established standardized medicinal dose for black mustard. As a culinary spice, it is simply used to taste in cooking.For topical or supplement products, follow the directions on the product label, and do not leave mustard plasters on the skin for long periods.

From our Black Mustard monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Mustard monograph & all interactions
Medication

About Misoprostol

What Is Misoprostol Used For?

Brand name: Cytotec

Cytotec (misoprostol) tablets and misoprostol tablets are approved to reduce the risk of gastric ulcers (stomach ulcers) in patients who take NSAIDs — nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, or diclofenac — and who are at high risk of ulcer complications. High-risk patients include older adults, people with serious ongoing illnesses, and those with a history of stomach ulcers.

It is important to note that misoprostol has not been shown to reduce the risk of duodenal ulcers (ulcers in the first part of the small intestine) in people taking NSAIDs. It also does not relieve the stomach pain or discomfort that NSAIDs can cause.

Most-Reported Side Effects for Misoprostol

From FAERS, the FDA’s public side-effect reporting system (16,478 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hemorrhage 1,322 reports
Abortion incomplete 1,159 reports
Nausea 1,031 reports
Arthralgia 977 reports
Rheumatoid arthritis 805 reports
See full Misoprostol drug information
Keep checking

Other Drugs & Black Mustard

Browse every other medication we’ve checked against Black Mustard — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Black Mustard page.

No interaction 2,743 drugs checked — show the list

We also checked Black Mustard against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Black Mustard list.

See the full Black Mustard interactions page
See every supplement checked against Misoprostol, ranked by severity
Evidence & sources

Black Mustard References

The 8 references that drive our Black Mustard monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  6. Anand, P., Murali, K. Y., Tandon, V., Chandra, R., and Murthy, P. S. Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) Koch in streptozotocin induced diabetic rats. Indian J Exp.Biol 2007;45(8):696-701.
  7. Anand, P., Murali, Y. K., Tandon, V., Murthy, P. S., and Chandra, R. Insulinotropic effect of aqueous extract of Brassica nigra improves glucose homeostasis in streptozotocin induced diabetic rats. Exp.Clin.Endocrinol.Diabetes 2009;117(6):251-256.
  8. Gulbransen, G. and Esernio-Jenssen, D. Aspiration of black mustard. J Toxicol.Clin.Toxicol. 1998;36(6):591-593. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Mustard and Misoprostol Together: Common Questions

Is it safe to take Black Mustard with Misoprostol?
We do not list a known interaction between Black Mustard and Misoprostol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Black Mustard and Misoprostol have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Black Mustard and Misoprostol at the same time of day?
At least one FDA label for a product containing Misoprostol says to take it with food. If you take Black Mustard on an empty stomach out of habit, keep them separate and take Misoprostol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Misoprostol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Black Mustard and Misoprostol combination checked?
Interactions in our licensed database are recorded against drug classes. Misoprostol is filed under 1 classification, and Black Mustard has documented interactions with 1 drug class — none of Misoprostol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Black Mustard interact with any other medications?
Yes. Black Mustard has 86 documented drug interactions in our database — Misoprostol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Misoprostol interact with any supplements?
Yes. Misoprostol has documented interactions with 17 supplements in our database — Black Mustard is not one of them. The Misoprostol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Mustard monograph Uses, safety profile, and every drug interaction in one place Misoprostol drug information The full plain-English guide to this medication Misoprostol supplement interactions Every supplement checked against Misoprostol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Misoprostol and Black Mustard?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.