Drug & supplement interaction

Black Nightshade + Dexamethasone

Dexamethasone brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Black Nightshade and Dexamethasone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Nightshade and Dexamethasone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dexamethasone and Black Nightshade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Black Nightshade at all — not against Dexamethasone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Nightshade safety at a glance

Black Nightshade overall Use caution Unripe berries and green parts can be toxic; only fully ripe fruit or properly cooked leaves are traditionally considered safer.
Pregnancy Likely Unsafe When used orally because of concerns it could be teratogenic; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally because of concerns it could be teratogenic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dexamethasone and Black Nightshade? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dexamethasone’s Own FDA Label Lists

This is not an interaction — none of it involves Black Nightshade. These are the most notable effects listed in the ADVERSE REACTIONS section of Dexamethasone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on
  • Loss of vision Worth acting on
  • Bone thinning Worth acting on
  • Muscle weakness Worth acting on
  • Bleeding in the gut Worth acting on
  • Trouble passing urine Worth acting on
  • Low potassium Worth acting on
  • A slow heartbeat Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on

Showing the 10 most notable of 49 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Dexamethasone. Read the label on DailyMed › Where a percentage is shown, it is the share of 308,307 voluntary FDA FAERS reports for Dexamethasone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Black Nightshade’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Nightshade side to compare — that is a limit of the record, not a statement that Black Nightshade has no side effects.

Special populations

Black Nightshade in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally because of concerns it could be teratogenic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Black Nightshade or Dexamethasone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Nightshade or Dexamethasone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dexamethasone

This page covers Black Nightshade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dexamethasone page lists 221 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 182 moderate · 35 minor.

From our pharmacist’s overview on the Dexamethasone page

“People take dexamethasone for serious reasons, a chemotherapy course, an autoimmune flare, brain swelling, so I want anyone on it to give its 221 supplement interactions genuine attention, starting with the four rated major. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Dexamethasone interaction page

One more smart check

Taking Black Nightshade as Part of a Dietary Supplement Product? Check It for Interactions

We hold 37 real supplement products containing Black Nightshade, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Nightshade. Even though Black Nightshade itself has no known interaction with Dexamethasone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Nightshade and Dexamethasone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Nightshade
Steady interest

#1,089 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dexamethasone
Top 25%

#663 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Nightshade reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Nightshade and Dexamethasone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Nightshade

What is Black Nightshade?

Black Nightshade
  • Digestive complaints
  • Skin conditions
  • Inflammation
  • Fever
  • Liver support (traditional)

Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health benefit is very limited, and the risk of toxicity is real. Do not use it as a supplement without medical guidance, and avoid it during pregnancy and breastfeeding.

Solanum nigrum · Solanaceae · Leaves, berries (ripe), and whole plant · Cooked leafy greens, fruit, traditional decoctions, dried herb, extracts

An interaction check asks whether these two react with each other — it does not ask whether Black Nightshade is a good idea for someone in your situation. Here is what our Black Nightshade record says about it on its own.

Black Nightshade: dosing

There is no established or standardized safe dose of black nightshade as a supplement. When it comes to wild plants, never guess at an amount or forage your own to use as medicine.

From our Black Nightshade monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Nightshade monograph & all interactions
Medication

About Dexamethasone

What Is Dexamethasone Used For?

Brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, Hemady, Dextenza

Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.

Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The ophthalmic/otic solution also treats steroid-responsive inflammation of the outer ear canal. A topical ointment (Seacall) is used for skin conditions including contact dermatitis, eczema, and neurodermatitis.

Most-Reported Side Effects for Dexamethasone

From FAERS, the FDA’s public side-effect reporting system (308,307 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 17,772 reports
Diarrhea 17,597 reports
Nausea 14,727 reports
Plasma cell myeloma 14,363 reports
Pneumonia 14,122 reports
See full Dexamethasone drug information
Keep checking

Other Drugs & Black Nightshade

Browse every other medication we’ve checked against Black Nightshade — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Black Nightshade against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Nightshade list.

See the full Black Nightshade interactions page
See every supplement checked against Dexamethasone, ranked by severity
Evidence & sources

Black Nightshade References

The 1 references that drive our Black Nightshade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Nightshade and Dexamethasone Together: Common Questions

Is it safe to take Black Nightshade with Dexamethasone?
We do not list a known interaction between Black Nightshade and Dexamethasone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Dexamethasone interact with any supplements?
Yes. Dexamethasone has documented interactions with 221 supplements in our database — Black Nightshade is not one of them. The Dexamethasone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Nightshade monograph Uses, safety profile, and every drug interaction in one place Dexamethasone drug information The full plain-English guide to this medication Dexamethasone supplement interactions Every supplement checked against Dexamethasone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dexamethasone and Black Nightshade?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.