Drug & supplement interaction

Bugleweed + Istradefylline

Istradefylline brand name: Nourianz.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bugleweed and Istradefylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bugleweed and Istradefylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Istradefylline and Bugleweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bugleweed safety at a glance

Bugleweed overall Use caution May affect thyroid function, so use only under the guidance of a healthcare provider.
Pregnancy Likely Unsafe When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally because it might have anti-prolactin activity; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Istradefylline and Bugleweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Istradefylline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Istradefylline is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Bugleweed has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Istradefylline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bugleweed Does Interact With Other Medications

Bugleweed has 16 moderate known drug interactions in our database — Istradefylline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Istradefylline)
Taking anything else?

Check Another of Your Medications Against Bugleweed

Covers the 2,830 medications we’ve checked against Bugleweed. Pick one to open its full report.

What to actually watch for

What Istradefylline’s Own FDA Label Lists

This is not an interaction — none of it involves Bugleweed. These are the most notable effects listed in the ADVERSE REACTIONS section of Istradefylline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 10.3% of FDA reports for Istradefylline
  • High blood sugar Worth acting on
  • A change in sex drive
  • Constipation mentioned in 6.0% of FDA reports for Istradefylline
  • Reduced appetite
  • Trouble sleeping
  • Dizziness mentioned in 7.1% of FDA reports for Istradefylline
  • Diarrhea
  • A skin rash
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Istradefylline. Read the label on DailyMed › Where a percentage is shown, it is the share of 5,920 voluntary FDA FAERS reports for Istradefylline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Bugleweed’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bugleweed side to compare — that is a limit of the record, not a statement that Bugleweed has no side effects.

Special populations

Bugleweed in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using.

Lactation Possibly Unsafe

When used orally because it might have anti-prolactin activity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Istradefylline

This page covers Bugleweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Istradefylline page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Istradefylline page

“Istradefylline (Nourianz) is added to levodopa to trim the daily 'off' time of Parkinson's disease, and its supplement list deserves genuine care. Most of the 138 ingredients here can change how the liver enzyme CYP3A4 handles the drug, so blood levels may drift too high or too low.”

Reviewed by 2 · Jul 18, 2026

Open the Istradefylline interaction page

One more smart check

Taking Bugleweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 29 real supplement products containing Bugleweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bugleweed. Even though Bugleweed itself has no known interaction with Istradefylline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bugleweed and Istradefylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bugleweed
Steady interest

#847 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Istradefylline
Top 10%

#273 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bugleweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bugleweed and Istradefylline records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bugleweed

What is Bugleweed?

Bugleweed
  • Mild overactive thyroid symptoms
  • Heart palpitations and rapid heartbeat
  • Anxiety and restlessness
  • Breast pain (mastalgia)
  • Premenstrual symptoms

Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because it may affect thyroid hormones, it should not be used without medical supervision, and it must be avoided in pregnancy and breastfeeding.

Lycopus virginicus · Lamiaceae · Aerial parts (leaves, stems, and flowering tops) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Bugleweed is a good idea for someone in your situation. Here is what our Bugleweed record says about it on its own.

Bugleweed: dosing

There is no well-established standardized dose for bugleweed. Do not exceed the recommended amount, and do not use it long-term without medical supervision.

From our Bugleweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bugleweed monograph & all interactions
Medication

About Istradefylline

What Is Istradefylline Used For?

Brand name: Nourianz

Nourianz (istradefylline) is used alongside levodopa/carbidopa in adults with Parkinson's disease. Specifically, it is meant to reduce 'off' episodes — periods when levodopa stops working as well and Parkinson's symptoms return or worsen.

It is an add-on therapy only; it is not used alone or as a replacement for levodopa/carbidopa.

Most-Reported Side Effects for Istradefylline

From FAERS, the FDA’s public side-effect reporting system (5,920 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 608 reports
Dyskinesia 482 reports
Dizziness 421 reports
Constipation 353 reports
Fall 344 reports
See full Istradefylline drug information
Keep checking

Other Drugs & Bugleweed

Browse every other medication we’ve checked against Bugleweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
16Moderate
0Minor
2,813No known interaction
16 Moderate 2,813 No interaction
Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Bugleweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Bugleweed list.

See the full Bugleweed interactions page
See every supplement checked against Istradefylline, ranked by severity
Evidence & sources

Bugleweed References

The 4 references that drive our Bugleweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bugleweed and Istradefylline Together: Common Questions

Is it safe to take Bugleweed with Istradefylline?
We do not list a known interaction between Bugleweed and Istradefylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bugleweed and Istradefylline combination checked?
Interactions in our licensed database are recorded against drug classes. Istradefylline is filed under 2 classifications, and Bugleweed has documented interactions with 1 drug class — none of Istradefylline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bugleweed interact with any other medications?
Yes. Bugleweed has 16 documented drug interactions in our database — Istradefylline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Istradefylline interact with any supplements?
Yes. Istradefylline has documented interactions with 138 supplements in our database — Bugleweed is not one of them. The Istradefylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bugleweed monograph Uses, safety profile, and every drug interaction in one place Istradefylline drug information The full plain-English guide to this medication Istradefylline supplement interactions Every supplement checked against Istradefylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Istradefylline and Bugleweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.