Bugleweed + Sodium Phenylbutyrate, Taurursodiol
Sodium Phenylbutyrate, Taurursodiol brand name: Relyvrio.
We found no known interaction between Bugleweed and Sodium Phenylbutyrate, Taurursodiol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Bugleweed and Sodium Phenylbutyrate, Taurursodiol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sodium Phenylbutyrate, Taurursodiol and Bugleweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bugleweed safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sodium Phenylbutyrate, Taurursodiol
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Phenylbutyrate, Taurursodiol is filed under 3 classifications — bile acid sequestrants, sodium-containing drugs, oral drugs. Bugleweed has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Sodium Phenylbutyrate, Taurursodiol’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Bugleweed Does Interact With Other Medications
Bugleweed has 16 moderate known drug interactions in our database — Sodium Phenylbutyrate, Taurursodiol isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Bugleweed
We haven’t checked that one against Bugleweed yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Bugleweed. Pick one to open its full report.
Bugleweed in Pregnancy & Breastfeeding
When used orally. Bugleweed has anti-gonadotropic and anti-thyrotropic activity; avoid using.
When used orally because it might have anti-prolactin activity; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Sodium Phenylbutyrate, Taurursodiol
This page covers Bugleweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Phenylbutyrate, Taurursodiol page lists 20 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 10 moderate · 9 minor.
From our pharmacist’s overview on the Sodium Phenylbutyrate, Taurursodiol page
“Relyvrio (sodium phenylbutyrate and taurursodiol) treats ALS, a disease where losing part of a dose is a real loss, and that is exactly what most of these 20 interactions threaten, so give them a hard look before adding any supplement. Seventeen involve ingredients, mostly fibers, gums, and mucilage-rich herbs, that can change how much…”
Reviewed by 2 · Jul 18, 2026
Open the Sodium Phenylbutyrate, Taurursodiol interaction page
Taking Bugleweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 29 real supplement products containing Bugleweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bugleweed. Even though Bugleweed itself has no known interaction with Sodium Phenylbutyrate, Taurursodiol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Bugleweed and Sodium Phenylbutyrate, Taurursodiol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,051 of 1,452 supplements looked up here in the last 7 days
#2,602 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bugleweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bugleweed and Sodium Phenylbutyrate, Taurursodiol records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bugleweed
What is Bugleweed?
- Mild overactive thyroid symptoms
- Heart palpitations and rapid heartbeat
- Anxiety and restlessness
- Breast pain (mastalgia)
- Premenstrual symptoms
Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because it may affect thyroid hormones, it should not be used without medical supervision, and it must be avoided in pregnancy and breastfeeding.
Lycopus virginicus · Lamiaceae · Aerial parts (leaves, stems, and flowering tops) · Tea, tincture, liquid extract, capsules, dried herb
An interaction check asks whether these two react with each other — it does not ask whether Bugleweed is a good idea for someone in your situation. Here is what our Bugleweed record says about it on its own.
Bugleweed: dosing
There is no well-established standardized dose for bugleweed. Do not exceed the recommended amount, and do not use it long-term without medical supervision.
From our Bugleweed monograph — the full record covers uses, side effects and every documented interaction.
About Sodium Phenylbutyrate and Taurursodiol
What Is Sodium Phenylbutyrate and Taurursodiol Used For?
Brand name: Relyvrio
-
Sodium phenylbutyrate and taurursodiol is used for the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken). Sodium phenylbutyrate is a histone deacetylase inhibitor. Taurursodiol is a bile acid. It is not known exactly how the combination of sodium phenylbutyrate and taurursodiol works, but it may reduce the breakdown and death of nerve cells associated with the worsening of ALS symptoms.
Other Drugs & Bugleweed
Browse every other medication we’ve checked against Bugleweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
16 interactions
- Levothyroxine ›
- Conjugated Estrogens ›
- Testosterone Undecanoate ›
- Levothyroxine Sodium ›
- Liotrix ›
- Desiccated Thyroid Extract ›
- Desiccated Thyroid Extract (prescription Drug) ›
- Menotropins ›
- Dextrothyroxine ›
- Human Chorionic Gonadotropin (hcg) ›
- Liothyronine ›
- Ospemifene ›
- Thyroglobulin ›
- Thyroid Hormone ›
- Levothyroxine, Liothyronine ›
- Liotrix, T4/t3 ›
No interaction 2,813 drugs checked — show the list
We also checked Bugleweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Methamphetamine ›
- Tirzepatide ›
- Ibuprofen ›
- Docusate ›
- Tadalafil ›
- Warfarin Sodium ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Isotretinoin ›
- Prednisone ›
- Semaglutide ›
- Lisdexamfetamine ›
- Metformin ›
- Propranolol ›
- Amitriptyline ›
- Methotrexate ›
- Amlodipine Besylate ›
- Amoxicillin ›
- Lisinopril ›
- Amphetamine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Bendamustine ›
- Pregabalin ›
- Lamotrigine ›
- Acyclovir ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Acetaminophen, Codeine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
- Acetaminophen, Aspirin, Caffeine ›
Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Bugleweed list.
Bugleweed References
The 4 references that drive our Bugleweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Sodium Phenylbutyrate, Taurursodiol Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Sodium Phenylbutyrate, Taurursodiol as a medicine that can lower these. This is not an interaction with Bugleweed — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Sodium Phenylbutyrate, Taurursodiol nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Bugleweed and Sodium Phenylbutyrate, Taurursodiol Together: Common Questions
Is it safe to take Bugleweed with Sodium Phenylbutyrate, Taurursodiol?
How was the Bugleweed and Sodium Phenylbutyrate, Taurursodiol combination checked?
Does Bugleweed interact with any other medications?
Does Sodium Phenylbutyrate, Taurursodiol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.