Drug & supplement interaction

Capers + Botulinum Toxin Type A

Botulinum Toxin Type A brand name: Botox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Capers and Botulinum Toxin Type A in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Capers and Botulinum Toxin Type A

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Botulinum Toxin Type A and Capers in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Capers safety at a glance

Capers overall Use caution Generally safe as a food, but concentrated supplements are not well studied.
Pregnancy Use caution Food amounts are likely fine, but avoid medicinal or concentrated doses due to lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but concentrated supplements lack safety data, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Botulinum Toxin Type A and Capers? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Capers Does Interact With Other Medications

Capers has 86 moderate known drug interactions in our database — Botulinum Toxin Type A isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Botulinum Toxin Type A)
Taking anything else?

Check Another of Your Medications Against Capers

Covers the 2,830 medications we’ve checked against Capers. Pick one to open its full report.

What to actually watch for

What Capers Itself Has Been Linked To

This is not an interaction — nothing below involves Botulinum Toxin Type A. It is the side-effect record for Capers on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Capers, this list is the first place to look.

  • A skin rash Additional detail

    “Orally, capers seem to be well tolerated. No adverse effects have been reported in clinical research; however, a high-quality assessment of safety has not been conducted. Topically, capers can cause contact dermatitis.”

    Capers · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 96124. Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
    2. 12742. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.

    “Topically, capers can cause contact dermatitis.”

    Capers · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 12742. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.

Everything above comes from the Natural Medicines adverse-effect record for Capers — expand a row for the licensed statement it rests on. We haven’t matched Botulinum Toxin Type A to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Botulinum Toxin Type A.

From our Q&A

Questions About Capers or Botulinum Toxin Type A

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Capers or Botulinum Toxin Type A, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Capers as Part of a Dietary Supplement Product? Check It for Interactions

We hold 53 real supplement products containing Capers, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Capers. Even though Capers itself has no known interaction with Botulinum Toxin Type A, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Capers and Botulinum Toxin Type A Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Capers
Top half

#647 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Botulinum Toxin Type A
Top half

#1,052 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Capers reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Capers and Botulinum Toxin Type A records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Capers

What is Capers?

  • Digestive support
  • Antioxidant source
  • Blood sugar support
  • Anti-inflammatory
  • Skin and traditional tonic uses

Capers are the edible pickled flower buds of the Capparis spinosa shrub, used widely as food and in traditional medicine. They contain antioxidant plant compounds, but high-quality human studies on health benefits are limited, so the supplement claims remain largely unproven. As a food, capers are generally safe, but talk to your pharmacist or doctor before using concentrated extracts.

Capparis spinosa · Capparaceae · Flower buds, fruit, root bark, and leaves · Pickled or brined buds (food), capsules, extracts, dried powder

An interaction check asks whether these two react with each other — it does not ask whether Capers is a good idea for someone in your situation. Here is what our Capers record says about it on its own.

Capers: dosing

There is no established standard dose for capers as a supplement. As a food, people simply use them as a flavoring in small amounts.For capsules or extracts, follow the directions on the product label, since strengths vary widely between brands.

From our Capers monograph — the full record covers uses, side effects and every documented interaction.

Read the full Capers monograph & all interactions
Medication

About OnabotulinumtoxinA Injection

What Is OnabotulinumtoxinA Injection Used For?

Brand name: Botox

Botox is approved to treat a wide range of conditions in adults and some children. These include overactive bladder (OAB) with urge incontinence, urinary incontinence caused by nerve-related bladder overactivity (in adults and in children aged 5 and older), prevention of headaches in adults with chronic migraine (15 or more headache days per month), muscle stiffness (spasticity) in patients aged 2 and older, cervical dystonia (abnormal head position and neck pain), severe underarm sweating (primary axillary hyperhidrosis) when topical treatments haven't worked, eyelid spasms (blepharospasm) in patients aged 12 and older, and crossed eyes (strabismus) in patients aged 12 and older.

BOTOX Cosmetic is a separate product containing the same active ingredient but with its own approved cosmetic uses. Both products are given by injection and are not interchangeable with other botulinum toxin products. Botox has not been shown to work for episodic migraine (14 or fewer headache days per month), and its safety for excessive sweating in body areas other than the underarms has not been established.

Most-Reported Side Effects for Botulinum Toxin Type A

From FAERS, the FDA’s public side-effect reporting system (12,344 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,596 reports
Drug intolerance 1,333 reports
Nausea 1,266 reports
Migraine 1,176 reports
Dizziness 1,126 reports
See full OnabotulinumtoxinA Injection drug information
Keep checking

Other Drugs & Capers

Browse every other medication we’ve checked against Capers — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Capers page.

No interaction 2,743 drugs checked — show the list

We also checked Capers against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Capers list.

See the full Capers interactions page
See every supplement checked against Botulinum Toxin Type A, ranked by severity
Evidence & sources

Capers References

The 3 references that drive our Capers monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.
  2. Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
  3. Vahid H, Bonakdaran S, Khorasani ZM, et al. Effect of Capparis spinosa extract on metabolic parameters in patients with type-2 diabetes: A randomized controlled trial. Endocr Metab Immune Disord Drug Targets. 2019;19(1):100-107. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Capers and Botulinum Toxin Type A Together: Common Questions

Is it safe to take Capers with Botulinum Toxin Type A?
We do not list a known interaction between Capers and Botulinum Toxin Type A. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Capers interact with any other medications?
Yes. Capers has 86 documented drug interactions in our database — Botulinum Toxin Type A is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Capers monograph Uses, safety profile, and every drug interaction in one place OnabotulinumtoxinA Injection drug information The full plain-English guide to this medication Botulinum Toxin Type A supplement interactions Every supplement checked against Botulinum Toxin Type A, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Botulinum Toxin Type A and Capers?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.