Drug & supplement interaction

Cassava + Tipiracil Hydrochloride, Trifluridine

Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Cassava and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cassava and Tipiracil Hydrochloride, Trifluridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Cassava in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cassava safety at a glance

Cassava overall Use caution Properly cooked cassava is a common food, but raw or poorly processed cassava can cause cyanide poisoning.

Pregnancy Possibly Unsafe When used orally as a food, especially in large quantities. Animal research suggests that consuming milled cassava powder as 80% of the diet during the first 15... Read the full pregnancy detail

Breastfeeding Possibly Unsafe When used orally in food amounts, especially in large quantities. Excess consumption of cassava during lactation may increase the risk of exposing the infant to... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tipiracil Hydrochloride, Trifluridine and Cassava? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Cassava has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cassava Does Interact With Other Medications

Cassava has 16 moderate known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Tipiracil Hydrochloride, Trifluridine)

Taking anything else?

Check Another of Your Medications Against Cassava

Covers the 2,830 medications we’ve checked against Cassava. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cassava and Tipiracil Hydrochloride, Trifluridine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Diarrhea / Vomiting / Nausea Additional detail
Cassava
“Orally, cassava may cause cyanide poisoning. Cassava, especially the bitter variety, contains cyanogenic glycosides. If not removed during processing, these constituents are converted to cyanogens. Symptoms of cyanide poisoning can include vomiting, nausea, stomach pains, and diarrhea, as well as dizziness, weakness, and headache..”

Cassava · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

26585. Cardoso AP, Mirione E, Ernesto M, et al. Processing of cassava roots to remove cyanogens. Journal of Food Composition and Analysis 2005;18(5):451-60. DOI

25841. Hernandez T, Lundquist P, Oliveira L, et al. Fate in humans of dietary intake of cyanogenic glycosides from roots of sweet cassava consumed in Cuba. Nat Toxins 1995;3(2):114-7. PubMed

25843. Ariffin WA, Choo KE, Karnaneedi S. Cassava (ubi kayu) poisoning in children. Med J Malaysia 1992;47(3):231-4.

25844. Tylleskar T, Banea M, Bikangi N, et al. Cassava cyanogens and konzo, an upper motoneuron disease found in Africa. Lancet 1992;339(8787):208-11. PubMed

25854. Assan R, Assan D, Thiebaut MF, et al. [Diabetogenic tropical pancreatitis]. Diabete Metab 1988;14(3):299-312.

25856. Balakrishnan V, Unnikrishnan AG, Thomas V, et al. Chronic pancreatitis. A prospective nationwide study of 1,086 subjects from India. JOP 2008;9(5):593-600.
“Orally, cassava can cause cyanide poisoning. Cassava, especially the bitter varieties, contains cyanogenic glycosides. If not removed during processing, these constituents are converted to cyanogens. Gastrointestinal symptoms of cyanide poisoning can include vomiting, nausea, stomach pains, and diarrhea.”

Cassava · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

26585. Cardoso AP, Mirione E, Ernesto M, et al. Processing of cassava roots to remove cyanogens. Journal of Food Composition and Analysis 2005;18(5):451-60. DOI
Tipiracil Hydrochloride, Trifluridine

Listed in the ADVERSE REACTIONS section of the FDA label for Tipiracil Hydrochloride, Trifluridine. Read the label on DailyMed ›

Reported for Cassava but not commonly for Tipiracil Hydrochloride, Trifluridine: shortness of breath, an allergic reaction, a change in thyroid levels and loss of vision.

Effects for Tipiracil Hydrochloride, Trifluridine come from the ADVERSE REACTIONS section of its FDA label; effects for Cassava come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Cassava in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally as a food, especially in large quantities. Animal research suggests that consuming milled cassava powder as 80% of the diet during the first 15 days of pregnancy can cause teratogenic effects, including intrauterine growth restriction, limb defects, and abnormally small brain (microencephaly). Also, epidemiological evidence suggests that pregnant women who regularly consume dietary cassava in the form of gari during pregnancy have higher levels of thiocyanate, which has negative effects on fetal birthweight, compared to those who do not consume cassava. ...when applied intravaginally. Inserting 2-3 cm of cassava stalk into the vagina has been used to induce abortion and labor.

Lactation Possibly Unsafe

When used orally in food amounts, especially in large quantities. Excess consumption of cassava during lactation may increase the risk of exposing the infant to thiocyanate, which can negatively affect thyroid function in the infant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Cassava Should Not Break It

At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Cassava on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.

From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine

This page covers Cassava only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

Open the Tipiracil Hydrochloride, Trifluridine interaction page

One more smart check

Taking Cassava as Part of a Dietary Supplement Product? Check It for Interactions

We hold 35 real supplement products containing Cassava, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cassava. Even though Cassava itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cassava and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cassava

Steady interest

#1,225 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tipiracil Hydrochloride, Trifluridine

Steady interest

#1,848 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cassava reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cassava and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cassava

What is Cassava?

Dietary staple/source of carbohydrates
Fertility aid (to conceive twins)
Digestive support
General energy
Gluten-free flour alternative

Cassava is a starchy root vegetable that feeds millions of people worldwide, but it must be properly cooked or processed because the raw plant contains compounds that release cyanide. As a supplement, it is marketed for fertility and twin conception, but there is no good scientific evidence to support these claims. Always prepare cassava correctly and talk to your pharmacist or doctor before using cassava products for health reasons.

Manihot esculenta · Euphorbiaceae · Starchy root (tuber) and leaves · Whole root, flour, tapioca, dried powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Cassava is a good idea for someone in your situation. Here is what our Cassava record says about it on its own.

Cassava: dosing

There is no established or standardized dose for cassava as a supplement. As a food, it is simply prepared and eaten in normal serving sizes after proper cooking.For cassava supplements or flour products, follow the directions on the product label.

From our Cassava monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cassava monograph & all interactions

Medication

About Trifluridine and Tipiracil

What Is Trifluridine and Tipiracil Used For?

Brand name: Lonsurf

Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.

Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.

See full Trifluridine and Tipiracil drug information

Keep checking

Other Drugs & Cassava

Browse every other medication we’ve checked against Cassava — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

16Moderate

0Minor

2,813No known interaction

16 Moderate 2,813 No interaction

Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Cassava against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Cassava list.

See the full Cassava interactions page

See every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity

Evidence & sources

Cassava References

The 30 references that drive our Cassava monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hernandez T, Lundquist P, Oliveira L, et al. Fate in humans of dietary intake of cyanogenic glycosides from roots of sweet cassava consumed in Cuba. Nat Toxins 1995;3(2):114-7. PubMed
Ariffin WA, Choo KE, Karnaneedi S. Cassava (ubi kayu) poisoning in children. Med J Malaysia 1992;47(3):231-4.
Tylleskar T, Banea M, Bikangi N, et al. Cassava cyanogens and konzo, an upper motoneuron disease found in Africa. Lancet 1992;339(8787):208-11. PubMed
Akindahunsi AA, Grissom FE, Adewusi SR, et al. Parameters of thyroid function in the endemic goitre of Akungba and Oke-Agbe villages of Akoko area of southwestern Nigeria. Afr J Med Med Sci 1998;27(3-4):239-42.
Osman BA, Ng ML, Bakar AA, Khalid BA. The effect of cassava leave intake on thyroid hormone and urinary iodine. East Afr Med J 1993;70(5):314-5.
Gaitan E, Cooksey RC, Legan J, et al. Antithyroid effects in vivo and in vitro of babassu and mandioca: a staple food in goiter areas of Brazil. Eur J Endocrinol 1994;131(2):138-44. PubMed
Geelhoed GW. Metabolic maladaptation: individual and social consequences of medical intervention in correcting endemic hypothyroidism. Nutrition 1999;15(11-12):908-32. DOI
Biassoni P, Ravera G, Bertocchi J, et al. Influence of dietary habits on thyroid status of a nomadic people, the Bororo shepherds, roaming a central African region affected by severe iodine deficiency. Eur J Endocrinol 1998;138(6):681-5. PubMed
Delange F. The disorders induced by iodine deficiency. Thyroid 1994;4(1):107-28. PubMed
Delange F. [The role of goitrogenic factors distinct from iodine deficiency in the etiology of goiter]. Ann Endocrinol (Paris) 1988;49(4-5):302-5.
Assan R, Assan D, Thiebaut MF, et al. [Diabetogenic tropical pancreatitis]. Diabete Metab 1988;14(3):299-312.
Balakrishnan V, Unnikrishnan AG, Thomas V, et al. Chronic pancreatitis. A prospective nationwide study of 1,086 subjects from India. JOP 2008;9(5):593-600.
Cliff J, Lundqvist P, Martensson J, et al. Association of high cyanide and low sulphur intake in cassava-induced spastic paraparesis. Lancet 1985;2(8466):1211-3. PubMed
Paula Cardoso A, Ernesto M, Nicala D, et al. Combination of cassava flour cyanide and urinary thiocyanate measurements of school children in Mozambique. Int J Food Sci Nutr 2004;55(3):183-90. PubMed
Dumas M, Giordano C, Ndiaye IP, et al. [The concept of tropical neuromyelopathy]. Bull Soc Pathol Exot Filiales 1988;81(2):183-8.
Tucker K, Hedges TR. Food shortages and an epidemic of optic and peripheral neuropathy in Cuba. Nutr Rev 1993;51(12):349-57. PubMed
Wilson J. Cyanide in human disease: a review of clinical and laboratory evidence. Fundam Appl Toxicol 1983;3(5):397-9. DOI
Grange AO. Evaluation of cassava-salt suspension in the management of acute diarrhoea in infants and children. J Diarrhoeal Dis Res 1994;12(1):55-8.
Olusanya O, Olanrewaju DM, Oluwole FA. Studies on the effectiveness, safety and acceptability of fluids from local foodstuffs in the prevention and management of dehydration caused by diarrhoea in children. J Trop Pediatr 1994;40(6):360-4. PubMed
Singh JD. The teratogenic effects of dietary Cassava on the pregnant albino rat: a preliminary report. Teratology 1981;24(3):289-91. PubMed
Oforofuo IA, Omu AE. Serum thiocyanate levels in a normal population and in pregnancy in Benin City, Nigeria: preliminary report. Int J Gynaecol Obstet 1991;34(1):65-9. PubMed
Nikolajsen T, Nielsen F, Rasch V, et al. Uterine contraction induced by Tanzanian plants used to induce abortion. J Ethnopharmacol 2011;137(1):921-5. PubMed
Cardoso AP, Mirione E, Ernesto M, et al. Processing of cassava roots to remove cyanogens. Journal of Food Composition and Analysis 2005;18(5):451-60. DOI
Dorea JG. Maternal thiocyanate and thyroid status during breast-feeding. J Am Coll Nutr 2004;23(2):97-101. PubMed
Sánchez D, Sus S, Ortiz B, Sánchez J, Cardona R. Cross-reactivity Between Cassava and Latex in a Colombian Patient With an Anaphylactic Reaction. J Investig Allergol Clin Immunol. 2015;25(6):453-5.
Rosa ML, Falcão PM, Yokoo EM, et al. Brazil's staple food and incident diabetes. Nutrition. 2014 Mar;30(3):365-8. Epub 2013 Oct 2. PubMed
Banea JP, Bradbury JH, Mandombi C, et al. Control of konzo by detoxification of cassava flour in three villages in the Democratic Republic of Congo. Food Chem Toxicol. 2013 Oct;60:506-13. Epub 2013 Aug 11. PubMed
Boivin MJ, Okitundu D, Makila-Mabe Bumoko G, et al. Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava. Pediatrics. 2013 Apr;131(4):e1231-9. Epub 2013 Mar 25. PubMed
Antolin-Amerigo D, Rodriguez-Rodriguez M, Barbarroja-Escudero J, Postigo Resa I, Uribe-Etxebarría MC, Alvarez-Mon M. Hypersensitivity to cassava: an allergen-based assessment. J Investig Allergol Clin Immunol. 2012;22(5):385-6.
Santos KS, Galvao CE, Gadermaier G, et al. Allergic reactions to manioc (Manihot esculenta Crantz): identification of novel allergens with potential involvement in latex-fruit syndrome. J Allergy Clin Immunol. 2011 Dec;128(6):1367-9. Epub 2011 Aug 19. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cassava and Tipiracil Hydrochloride, Trifluridine Together: Common Questions

Is it safe to take Cassava with Tipiracil Hydrochloride, Trifluridine?

We do not list a known interaction between Cassava and Tipiracil Hydrochloride, Trifluridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Cassava and Tipiracil Hydrochloride, Trifluridine have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Cassava and Tipiracil Hydrochloride, Trifluridine at the same time of day?

At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Cassava on an empty stomach out of habit, keep them separate and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tipiracil Hydrochloride, Trifluridine products can differ — so check the directions on your own box. This is about absorption, not an interaction.

How was the Cassava and Tipiracil Hydrochloride, Trifluridine combination checked?

Interactions in our licensed database are recorded against drug classes. Tipiracil Hydrochloride, Trifluridine is filed under 1 classification, and Cassava has documented interactions with 1 drug class — none of Tipiracil Hydrochloride, Trifluridine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cassava interact with any other medications?

Yes. Cassava has 16 documented drug interactions in our database — Tipiracil Hydrochloride, Trifluridine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?

Yes. Tipiracil Hydrochloride, Trifluridine has documented interactions with 17 supplements in our database — Cassava is not one of them. The Tipiracil Hydrochloride, Trifluridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cassava monograph Uses, safety profile, and every drug interaction in one place Trifluridine and Tipiracil drug information The full plain-English guide to this medication Tipiracil Hydrochloride, Trifluridine supplement interactions Every supplement checked against Tipiracil Hydrochloride, Trifluridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 30 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tipiracil Hydrochloride, Trifluridine and Cassava?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.