Drug & supplement interaction

Chelation Therapy Products + Glycerin

Glycerin brand name: Osmoglyn.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chelation Therapy Products and Glycerin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Chelation Therapy Products and Glycerin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glycerin and Chelation Therapy Products in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chelation Therapy Products safety at a glance

Chelation Therapy... overall Use caution Real chelation is a medical treatment that needs supervision; OTC 'chelation' products are unproven and risky.
Pregnancy Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glycerin and Chelation Therapy Products? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glycerin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glycerin is filed under a single classification — oral drugs. Chelation Therapy Products has documented interactions with 3 drug classes — the most serious being insulin (major), diuretic drugs (moderate) and warfarin (coumadin) (moderate) — and none of Glycerin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chelation Therapy Products Does Interact With Other Medications

Chelation Therapy Products has 13 major, 77 moderate known drug interactions in our database — Glycerin isn’t one of them. If you take anything else, check it against the full list below.

Major 13 Moderate 77 No known interaction 2,740 (incl. Glycerin)
Taking anything else?

Check Another of Your Medications Against Chelation Therapy Products

Covers the 2,830 medications we’ve checked against Chelation Therapy Products. Pick one to open its full report.

What to actually watch for

What Chelation Therapy Products Itself Has Been Linked To

This is not an interaction — nothing below involves Glycerin. It is the side-effect record for Chelation Therapy Products on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chelation Therapy Products, this list is the first place to look. 8 entries are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine / Chest pain Worth acting on Additional detail

    “Intravenously, ethylenediamene tetraacetic acid (EDTA) can sometimes cause urinary urgency and frequency. However, the most serious adverse effect of EDTA is kidney toxicity for doses greater than 3 grams daily (15). In a clinical trial in patients with angina, intravenous disodium EDTA has resulted in an elevation of serum creatinine.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in angina.

    6 sources cited
    1. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    2. 108095. Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Pediatrics 2006;118(2):e534-6. PubMed
    3. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
    4. 108102. Lamas GA, Hussein SJ. EDTA chelation therapy meets evidence-based medicine. Complement Ther Clin Pract 2006;12(3):213-5. PubMed
    5. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    6. 108104. Knudtson ML, Wyse DG, Galbraith PD, et al. Chelation therapy for ischemic heart disease: a randomized controlled trial. JAMA. 2002;287(4):481-6. PubMed
  • Muscle weakness Worth acting on Additional detail

    “Intravenously, disodium ethylenediamene tetraacetic acid (EDTA) can occasionally cause muscle cramps, back pains, muscle weakness, and myalgias (15). In a large clinical trial in patients with a previous myocardial infarction, the rate of hypocalcemia was 6.2% in patients given disodium EDTA, compared with 3.5% of those given placebo;”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in hypocalcemia.

    2 sources cited
    1. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    2. 94985. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
  • A heart attack Worth acting on Additional detail

    “Intravenously, chelation therapy products such as 2,3-dimercaptopropane-1-sulfonate (DMPS) or ethylenediamene tetraacetic acid (EDTA) have been associated with hypotension and irregular heartbeat. Intravenously, EDTA can also cause thrombophlebitis.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    2. 5771. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
    3. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    4. 108105. Wax PM. Current use of chelation in American health care. J Med Toxicol 2013;9(4):303-7. PubMed
    5. 108106. American College of Medical Toxicology and The American Academy of Clinical Toxicology. https://www.choosingwisely.org/clinician-lists/american-college-academy-medical-toxicology-chelation/. Accessed May 18, 2022.
    6. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
  • Blood clots / Heart failure Worth acting on Additional detail

    “The use of chelation therapy products for unproven indications, or in unapproved doses or routes of administration, is generally considered to be unsafe.

    Most Common Adverse Effects:

    Orally: Gastrointestinal upset, nausea.

    Intravenous: Abdominal cramps, anorexia, burning and pain at infusion site, diarrhea, headache, nausea, vomiting.

    Serious Adverse Effects (Rare):

    Orally: Allergic reactions, Stevens-Johnson syndrom…”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in anorexia.

  • An irregular heartbeat Worth acting on Additional detail

    “Intravenously, calcium disodium ethylenediamene tetraacetic acid (EDTA) can cause zinc deficiency and hypercalcemia. Disodium EDTA can occasionally reduce magnesium and potassium serum concentrations, and rarely cause insulin shock.

    Disodium EDTA, when given as a rapid infusion or highly concentrated solution, can cause hypocalcemia, leading to tetany, convulsions, cardiac arrhythmias, cardiac failure, respiratory ar…”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 5771. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
    2. 5772. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
    3. 5737. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
    4. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    5. 94984. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
    6. 94985. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
  • A severe skin reaction Worth acting on Additional detail

    “There is a case report of Stevens-Johnson syndrome after two weeks of oral 2,3-dimercaptopropane-1-sulfonate (DMPS) chelation therapy in a child with chronic mercury exposure. Symptoms included a widespread eruption of red, itchy macules which gradually improved after discontinuation of DMPS therapy.”

    Chelation Therapy Products · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 108112. Van der Linde AAA, Pillen S, Gerrits GPJM, Bouwes Bavinck JN. Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy. Clin Toxicol (Phila). 2008;46(5):479-81. PubMed
    2. 108099. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
    3. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    4. 108103. Villarruz MV, Dans A, Tan F. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database Syst Rev 2002;(4):CD002785. PubMed
    5. 5744. Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed
  • Seizures Worth acting on Additional detail

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Blood clots / Heart failure above.

  • Kidney problems Worth acting on Additional detail

    Recorded for Chelation Therapy Products in the same Natural Medicines adverse-effect record shown under Blood clots / Heart failure above.

Showing the 10 most notable of 32 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Chelation Therapy Products — expand a row for the licensed statement it rests on. We haven’t matched Glycerin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Glycerin.

Special populations

Chelation Therapy Products in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When unregulated chelation therapy products are used orally or parentally or when prescription chelation therapy products are used for unproven indications and/or in unapproved doses or routes of administration. The American College of Medical Toxicology and The American Academy of Clinical Toxicology recommend against the unapproved use of chelation therapy products. Chelation therapy products can have teratogenic effects and result in severe side effects including dehydration, hypocalcemia, kidney failure, neurodevelopmental toxicity, and death.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Glycerin

This page covers Chelation Therapy Products only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glycerin page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Glycerin page

“Glycerin taken by mouth (Osmoglyn) is an osmotic medicine, often used to bring down pressure inside the eye quickly, and its effect depends on the full dose actually reaching your bloodstream. That is why this list deserves genuine care rather than a shrug.”

Reviewed by 2 · Jul 18, 2026

Open the Glycerin interaction page

How much people look this up

Where Chelation Therapy Products and Glycerin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chelation Therapy Products
Steady interest

#1,325 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glycerin
Top 25%

#518 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chelation Therapy Products reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chelation Therapy Products and Glycerin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chelation Therapy Products

What is Chelation Therapy Products?

  • Heavy metal poisoning (lead, mercury, arsenic, iron)
  • Marketed for heart and artery health
  • Promoted for 'detoxification'
  • Promoted for circulation problems
  • Sometimes promoted for autism (not supported)

Chelation therapy uses binding agents (like EDTA, DMSA, or DMPS) that latch onto certain metals so the body can remove them. It is an FDA-approved, doctor-supervised treatment only for proven heavy metal poisoning; over-the-counter 'chelation' supplements and unsupervised IV chelation for heart disease or detox are not proven safe or effective and can be dangerous. Talk to your doctor or pharmacist before considering any chelation product.

Not applicable (synthetic and oral binding agents) · Intravenous (IV) infusions, oral capsules, suppositories, and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chelation Therapy Products is a good idea for someone in your situation. Here is what our Chelation Therapy Products record says about it on its own.

Chelation Therapy Products: dosing

There is no safe "do-it-yourself" chelation dose. When chelation is medically needed for poisoning, the agent, dose, and schedule are chosen by a doctor based on the specific metal, blood levels, body weight, and kidney function, with close monitoring.Over-the-counter "chelation" supplements are not standardized, and their actual contents and strength are uncertain. We do not recommend self-dosing these products.If a product label gives directions, do not assume they are safe or effective.

From our Chelation Therapy Products monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chelation Therapy Products monograph & all interactions
Medication

About Glycerin

Most-Reported Side Effects for Glycerin

From FAERS, the FDA’s public side-effect reporting system (23,937 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Oral herpes 2,427 reports
Eye irritation 1,068 reports
Eye pain 1,013 reports
Incorrect drug administration duration 806 reports
Herpes simplex 709 reports
Keep checking

Other Drugs & Chelation Therapy Products

Browse every other medication we’ve checked against Chelation Therapy Products — both the ones with a known interaction and the ones without. Select any drug for the full detail.

13Major
77Moderate
0Minor
2,739No known interaction
13 Major 77 Moderate 2,739 No interaction
Major

13 interactions

Moderate

77 interactions

Showing 60 of 77 moderate interactions — see all 77 on the Chelation Therapy Products page.

No interaction 2,739 drugs checked — show the list

We also checked Chelation Therapy Products against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,739 medications checked with no known interaction — see the full Chelation Therapy Products list.

See the full Chelation Therapy Products interactions page
See every supplement checked against Glycerin, ranked by severity
Evidence & sources

Chelation Therapy Products References

The 21 references that drive our Chelation Therapy Products monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22:1067-9.. PubMed
  3. Grier MT, Meyers DG. So much writing, so little science: a review of 37 years literature on edetate sodium chelation therapy. Ann Pharmacother 1993;27:1504-9.
  4. Christensen K, Theilade D. Edta chelation therapy: an ethical problem. Med Hypotheses 1999;53:69-70. PubMed
  5. Lacy CF, Armstrong LL, Ingrim NB, et al. Drug Information Handbook. 6th ed. Hudson, OH:Lexi-Comp Inc 1998:439-41.
  6. Ellsworth AJ, Witt DM, Dugdale DC, et al. Medical Drug Reference. Saint Louis, MO: Mosby-Year Book Inc 1998:302-3.
  7. Fountain JS, Reith DM. Dangers of "EDTA". N Z Med J 2014;127:126-7.
  8. Lamas GA, Goertz C, Boineau R, et al. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. JAMA 2013;309:1241-50. PubMed
  9. Russo PA, Banovic T, Wiese MD, et al. Systemic allergy to EDTA in local anesthetic and radiocontrast media. J Allergy Clin Immunol Pract 2014;2:225-9. PubMed
  10. Centers for Disease Control and Prevention (CDC). Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. MMWR Morb Mortal Wkly Rep 2006;55(8):204-7.
  11. Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005. Pediatrics 2006;118(2):e534-6. PubMed
  12. Baxter AJ, Krenzelok EP. Pediatric fatality secondary to EDTA chelation. Clin Toxicol (Phila) 2008;46(10):1083-4. PubMed
  13. Atwood KC, Woeckner E. In pediatric fatality, edetate disodium was no accident. Clin Toxicol (Phila) 2009;47(3):256. PubMed
  14. James S, Stevenson SW, Silove N, Williams K. Chelation for autism spectrum disorder (ASD). Cochrane Database Syst Rev 2015;5(5):CD010766. PubMed
  15. Lamas GA, Hussein SJ. EDTA chelation therapy meets evidence-based medicine. Complement Ther Clin Pract 2006;12(3):213-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chelation Therapy Products and Glycerin Together: Common Questions

Is it safe to take Chelation Therapy Products with Glycerin?
We do not list a known interaction between Chelation Therapy Products and Glycerin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Chelation Therapy Products and Glycerin combination checked?
Interactions in our licensed database are recorded against drug classes. Glycerin is filed under 1 classification, and Chelation Therapy Products has documented interactions with 3 drug classes — none of Glycerin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chelation Therapy Products interact with any other medications?
Yes. Chelation Therapy Products has 90 documented drug interactions in our database — Glycerin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glycerin interact with any supplements?
Yes. Glycerin has documented interactions with 17 supplements in our database — Chelation Therapy Products is not one of them. The Glycerin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chelation Therapy Products monograph Uses, safety profile, and every drug interaction in one place Glycerin supplement interactions Every supplement checked against Glycerin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glycerin and Chelation Therapy Products?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.