Drug & supplement interaction

Collagen Type I (native) + Diltiazem

Diltiazem brand names: Cardizem, Cardizem SR, Diltiaz SR, Cardizem CD, Tiazac, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Collagen Type I (native) and Diltiazem in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Collagen Type I (native) and Diltiazem

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diltiazem and Collagen Type I (native) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Collagen Type I (native) at all — not against Diltiazem, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Collagen Type I (native) safety at a glance

Collagen Type I (n... overall Use caution Generally well tolerated for most adults, but quality and source vary widely between products.
Pregnancy Avoid Safety has not been established, so it is best to avoid unless your doctor approves.
Breastfeeding Avoid Not enough safety data exists, so avoid use while breastfeeding unless advised otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diltiazem and Collagen Type I (native)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Collagen Type I (native) and Diltiazem May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Collagen Type I (native)

    “Orally, dyspepsia occurred in one patient in one clinical trial.”

    Collagen Type I (native) · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 101769. Stancík R, Zvarka J, Hlavác M, Kubinec V, Rovenský J. Collagen type I in the treatment of painful osteoarthritis of the knee. Reumatologia. 2012;50(5):390-6. DOI

    Diltiazem

    Listed in the ADVERSE REACTIONS section of the FDA label for Diltiazem. Read the label on DailyMed ›

Effects for Diltiazem come from the ADVERSE REACTIONS section of its FDA label; effects for Collagen Type I (native) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 34,400 voluntary FDA FAERS reports for Diltiazem that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Collagen Type I (native) or Diltiazem

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Collagen Type I (native) or Diltiazem, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diltiazem

This page covers Collagen Type I (native) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diltiazem page lists 260 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 7 major · 214 moderate · 39 minor.

From our pharmacist’s overview on the Diltiazem page

“Someone on diltiazem (Cardizem, Tiazac) is usually managing blood pressure, angina, or a fast heart rhythm, so this list deserves genuine care. Seven of the 260 ingredients on file carry a major rating, and two of those are things people actually buy: grapefruit, which blocks the enzyme that clears diltiazem and can push its blood leve…”

Reviewed by 2 · Jul 18, 2026

Open the Diltiazem interaction page

How much people look this up

Where Collagen Type I (native) and Diltiazem Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Collagen Type I (native)
Steady interest

#1,284 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diltiazem
Top 10%

#246 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Collagen Type I (native) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Collagen Type I (native) and Diltiazem records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Collagen Type I (native)

What is Collagen Type I (native)?

  • Skin health and wrinkles
  • Joint comfort and arthritis
  • Bone strength
  • Hair and nail support
  • Wound and tissue repair

Type I collagen is the most abundant protein in human skin, bones, and tendons, and it is sold as a supplement to support skin, joints, and bones. 'Native' (undenatured) Type I collagen keeps its natural triple-helix structure rather than being broken down into peptides. Early research is promising for skin and joints, but evidence is still limited, and most products are generally well tolerated.

Skin, bones, tendons, scales, and connective tissue of cows, pigs, fish, or chicken · Powders, capsules, drinks, and undenatured (native) collagen tablets

An interaction check asks whether these two react with each other — it does not ask whether Collagen Type I (native) is a good idea for someone in your situation. Here is what our Collagen Type I (native) record says about it on its own.

Collagen Type I (native): dosing

There is no official standardized dose for native Type I collagen, and the right amount depends on the specific product. Doses used in studies vary widely depending on the form (powder versus tablet) and whether the collagen is native or hydrolyzed.The safest approach is to follow the directions on the product label and not exceed them.

From our Collagen Type I (native) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Collagen Type I (native) monograph & all interactions
Medication

About Diltiazem

What Is Diltiazem Used For?

Brand names: Cardizem, Cardizem SR, Diltiaz SR, Cardizem CD, Tiazac, Diltiaz XT, Diltiaz CD, Dilacor, Diltiaz, Cardizem LA, Dilacor XR, Cartia XT, Tiamate, Adizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Dilcardia SR, Dilzem SR, Dilzem XL, Slozem, Tildiem LA, Tildiem Retard, Viazem XL, Zemtard 120XL, Zemtard 180XL, Zemtard 240XL, Zemtard 300XL

Oral extended-release forms of diltiazem — including Matzim LA, Cardizem LA, Cartia, Cartia XT, Tiadylt ER, and various generic capsules and tablets — are used to treat high blood pressure (hypertension) and chronic stable angina (chest pain brought on by activity). Some capsule formulations, including Cartia, Cartia XT, and certain generics, are also approved for angina due to coronary artery spasm (sudden chest pain caused by a sudden tightening of a coronary artery).

Injectable forms of diltiazem are used in hospital settings to temporarily slow a dangerously fast heart rate in atrial fibrillation or atrial flutter (rapid, irregular heart rhythms), and to restore a normal heart rhythm in paroxysmal supraventricular tachycardia (PSVT) — sudden episodes of a very fast but regular heartbeat originating above the heart's lower chambers.

Most-Reported Side Effects for Diltiazem

From FAERS, the FDA’s public side-effect reporting system (34,400 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 3,309 reports
Fatigue 2,733 reports
Nausea 2,454 reports
Dizziness 2,174 reports
Diarrhea 2,113 reports
See full Diltiazem drug information
Keep checking

Other Drugs & Collagen Type I (native)

Browse every other medication we’ve checked against Collagen Type I (native) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Collagen Type I (native) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Collagen Type I (native) list.

See the full Collagen Type I (native) interactions page
See every supplement checked against Diltiazem, ranked by severity
Evidence & sources

Collagen Type I (native) References

The 1 references that drive our Collagen Type I (native) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Stancík R, Zvarka J, Hlavác M, Kubinec V, Rovenský J. Collagen type I in the treatment of painful osteoarthritis of the knee. Reumatologia. 2012;50(5):390-6. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Collagen Type I (native) and Diltiazem Together: Common Questions

Is it safe to take Collagen Type I (native) with Diltiazem?
We do not list a known interaction between Collagen Type I (native) and Diltiazem. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Collagen Type I (native) and Diltiazem have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Diltiazem interact with any supplements?
Yes. Diltiazem has documented interactions with 260 supplements in our database — Collagen Type I (native) is not one of them. The Diltiazem interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Collagen Type I (native) monograph Uses, safety profile, and every drug interaction in one place Diltiazem drug information The full plain-English guide to this medication Diltiazem supplement interactions Every supplement checked against Diltiazem, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diltiazem and Collagen Type I (native)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.