Drug & supplement interaction

Common Stonecrop + Colesevelam

Colesevelam brand names: WelChol, Lodalis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Common Stonecrop and Colesevelam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Colesevelam states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Common Stonecrop and Colesevelam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Colesevelam and Common Stonecrop in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Common Stonecrop at all — not against Colesevelam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Common Stonecrop safety at a glance

Common Stonecrop overall Use caution Limited safety data exist, and internal use can cause irritation, vomiting, and diarrhea.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best to avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Colesevelam and Common Stonecrop? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Common Stonecrop and Colesevelam May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Common Stonecrop

    “Orally, common stonecrop can cause vomiting and diarrhea when consumed in very large amounts (18).”

    Common Stonecrop · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Colesevelam

    Listed in the ADVERSE REACTIONS section of the FDA label for Colesevelam. Read the label on DailyMed ›

Reported for Common Stonecrop but not commonly for Colesevelam: diarrhea.

Effects for Colesevelam come from the ADVERSE REACTIONS section of its FDA label; effects for Common Stonecrop come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,014 voluntary FDA FAERS reports for Colesevelam that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Colesevelam Products Have a Food Rule — Common Stonecrop Should Not Break It

At least one FDA label for a product containing Colesevelam says to take it with food. If you take Common Stonecrop on an empty stomach out of habit, keep them separate — and take Colesevelam with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Colesevelam products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Colesevelam hydrochloride should be taken as follows ( 2.2 , 2.4 ): Tablets Take 6 tablets once daily or 3 tablets twice daily with a meal and liquid.

From the Dosage and Administration section of the FDA label we read for Colesevelam — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Common Stonecrop or Colesevelam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Common Stonecrop or Colesevelam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Colesevelam

This page covers Common Stonecrop only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Colesevelam page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Colesevelam page

“Colesevelam (WelChol, Lodalis) lowers cholesterol by binding bile acids in your gut, and every one of the 17 supplements on this list can interfere with how oral medicines are absorbed in that same territory. I would treat this list with genuine care, and the place to start is activated charcoal, the only major-rated entry.”

Reviewed by 2 · Jul 18, 2026

Open the Colesevelam interaction page

How much people look this up

Where Common Stonecrop and Colesevelam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Common Stonecrop
Steady interest

#1,172 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Colesevelam
Steady interest

#1,988 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Common Stonecrop reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Common Stonecrop and Colesevelam records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Common Stonecrop

What is Common Stonecrop?

Common Stonecrop
  • Wounds and skin irritation
  • Eczema and other skin conditions
  • Constipation (laxative use)
  • Urinary and bladder complaints
  • High blood pressure (folk use)

Common Stonecrop (Sedum acre) is a small succulent with a long history in European folk medicine, mostly applied to the skin or used as a laxative. There is very little modern scientific evidence to support any of its uses, and the plant can be irritating and may cause vomiting or diarrhea when swallowed, so it should be used with caution and ideally avoided internally.

Sedum acre · Crassulaceae · Above-ground parts (leaves, stems, and flowering tops), used fresh or dried · Fresh plant, dried herb, topical preparations, and rarely teas or tinctures

An interaction check asks whether these two react with each other — it does not ask whether Common Stonecrop is a good idea for someone in your situation. Here is what our Common Stonecrop record says about it on its own.

Common Stonecrop: dosing

There is no established or standardized dose for Common Stonecrop. Because it has not been studied in proper clinical trials, safe and effective amounts are simply not known.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Common Stonecrop monograph — the full record covers uses, side effects and every documented interaction.

Read the full Common Stonecrop monograph & all interactions
Medication

About Colesevelam

What Is Colesevelam Used For?

Brand names: WelChol, Lodalis

Colesevelam is used alongside diet and exercise to reduce high LDL cholesterol (the "bad" cholesterol) in adults with primary hyperlipidemia (high cholesterol). It is also approved to lower LDL cholesterol in boys and girls aged 10–17 who have heterozygous familial hypercholesterolemia (HeFH) — an inherited condition that causes very high cholesterol — when diet and lifestyle changes alone haven't worked.

Colesevelam tablets and oral suspension (Welchol and colesevelam hydrochloride products) are also used to improve blood sugar control in adults with type 2 diabetes, as an add-on to diet and exercise. Colesevelam is not for type 1 diabetes or diabetic ketoacidosis.

Most-Reported Side Effects for Colesevelam

From FAERS, the FDA’s public side-effect reporting system (2,014 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 241 reports
Dyspnea 172 reports
Cough 169 reports
Muscle spasms 163 reports
Nasopharyngitis 150 reports
See full Colesevelam drug information
Keep checking

Other Drugs & Common Stonecrop

Browse every other medication we’ve checked against Common Stonecrop — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Common Stonecrop against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Common Stonecrop list.

See the full Common Stonecrop interactions page
See every supplement checked against Colesevelam, ranked by severity
Evidence & sources

Common Stonecrop References

The 1 references that drive our Common Stonecrop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Common Stonecrop and Colesevelam Together: Common Questions

Is it safe to take Common Stonecrop with Colesevelam?
We do not list a known interaction between Common Stonecrop and Colesevelam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Common Stonecrop and Colesevelam have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Common Stonecrop and Colesevelam at the same time of day?
At least one FDA label for a product containing Colesevelam says to take it with food. If you take Common Stonecrop on an empty stomach out of habit, keep them separate and take Colesevelam with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Colesevelam products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Colesevelam interact with any supplements?
Yes. Colesevelam has documented interactions with 17 supplements in our database — Common Stonecrop is not one of them. The Colesevelam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Common Stonecrop monograph Uses, safety profile, and every drug interaction in one place Colesevelam drug information The full plain-English guide to this medication Colesevelam supplement interactions Every supplement checked against Colesevelam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Colesevelam and Common Stonecrop?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.