Drug & supplement interaction

Cursed Buttercup + Itraconazole

Itraconazole brand names: Sporanox, Sporanox Injection, Tolsura.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cursed Buttercup and Itraconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cursed Buttercup and Itraconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Itraconazole and Cursed Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Cursed Buttercup at all — not against Itraconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cursed Buttercup safety at a glance

Cursed Buttercup overall Avoid This plant is toxic and can cause skin blistering and serious poisoning if swallowed.
Pregnancy Likely Unsafe When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Itraconazole and Cursed Buttercup? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Cursed Buttercup and Itraconazole May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea reported in 3.4% of FDA reports for Itraconazole Additional detail

    Cursed Buttercup

    “Orally, fresh cursed buttercup has been reported to cause severe irritation of the gastrointestinal tract, diarrhea, and colic (18).”

    Cursed Buttercup · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Itraconazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Itraconazole, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Itraconazole come from the ADVERSE REACTIONS section of its FDA label; effects for Cursed Buttercup come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 11,613 voluntary FDA FAERS reports for Itraconazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Cursed Buttercup in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically. Oral use of cursed buttercup might stimulate uterine activity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Cursed Buttercup or Itraconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cursed Buttercup or Itraconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Itraconazole

This page covers Cursed Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Itraconazole page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 136 moderate · 40 minor.

From our pharmacist’s overview on the Itraconazole page

“Serious fungal infections are what itraconazole (Sporanox, Tolsura) is for, and the drug travels through CYP3A4, the liver enzyme that also handles a large share of supplements. That overlap is why this list reaches 182 ingredients, and it earns genuine care; start with the six rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Itraconazole interaction page

How much people look this up

Where Cursed Buttercup and Itraconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cursed Buttercup
Steady interest

#1,257 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Itraconazole
Top half

#1,359 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cursed Buttercup reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cursed Buttercup and Itraconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cursed Buttercup

What is Cursed Buttercup?

  • Traditional topical use for skin and joint complaints
  • Folk remedy for warts and skin growths (as a counterirritant)
  • Historical use for fevers
  • Traditional use for swelling or pain

Cursed Buttercup is a toxic wetland plant that can cause severe skin blistering and dangerous poisoning if eaten. It is not a safe or proven dietary supplement, and there is no reliable evidence supporting any medicinal use. Do not take it internally or apply it to your skin without medical supervision—in practice, it is best avoided entirely.

Ranunculus sceleratus · Ranunculaceae · Whole plant (leaves, stems, flowers); historically used topically · Fresh plant poultice or crushed leaves in traditional practice; not sold as a standardized supplement

An interaction check asks whether these two react with each other — it does not ask whether Cursed Buttercup is a good idea for someone in your situation. Here is what our Cursed Buttercup record says about it on its own.

Cursed Buttercup: dosing

There is no established or safe dose of Cursed Buttercup. It is not a recognized dietary supplement, and no reputable product provides standardized, tested amounts.Because the plant is toxic, the safest approach is to not use it at all.

From our Cursed Buttercup monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cursed Buttercup monograph & all interactions
Medication

About Itraconazole

What Is Itraconazole Used For?

Brand names: Sporanox, Sporanox Injection, Tolsura

Itraconazole capsules (including Sporanox capsules and generic itraconazole capsules) treat serious fungal infections — blastomycosis, histoplasmosis, and aspergillosis — in both people with normal immune systems and those who are immunocompromised. Capsule forms are also approved for nail fungus (onychomycosis) caused by dermatophytes in non-immunocompromised patients. Tolsura (a gelatin-coated capsule formulation) treats blastomycosis, histoplasmosis, and aspergillosis in adults, but is not approved for nail fungus and is not interchangeable with other itraconazole products.

Itraconazole oral solution is specifically approved for oropharyngeal candidiasis (thrush — a fungal infection of the mouth) and esophageal candidiasis (a fungal infection of the food pipe). Only the oral solution has been shown to work for these mouth and throat infections; capsules cannot be substituted for this use.

Most-Reported Side Effects for Itraconazole

From FAERS, the FDA’s public side-effect reporting system (11,613 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 590 reports
Dyspnea 489 reports
Pneumonia 484 reports
Nausea 459 reports
Diarrhea 398 reports
See full Itraconazole drug information
Keep checking

Other Drugs & Cursed Buttercup

Browse every other medication we’ve checked against Cursed Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Cursed Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cursed Buttercup list.

See the full Cursed Buttercup interactions page
See every supplement checked against Itraconazole, ranked by severity
Evidence & sources

Cursed Buttercup References

The 2 references that drive our Cursed Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cursed Buttercup and Itraconazole Together: Common Questions

Is it safe to take Cursed Buttercup with Itraconazole?
We do not list a known interaction between Cursed Buttercup and Itraconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Cursed Buttercup and Itraconazole have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Itraconazole interact with any supplements?
Yes. Itraconazole has documented interactions with 182 supplements in our database — Cursed Buttercup is not one of them. The Itraconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cursed Buttercup monograph Uses, safety profile, and every drug interaction in one place Itraconazole drug information The full plain-English guide to this medication Itraconazole supplement interactions Every supplement checked against Itraconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Itraconazole and Cursed Buttercup?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.