Divi-divi + Tolnaftate
Tolnaftate brand name: Tinactin.
We found no known interaction between Divi-divi and Tolnaftate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Divi-divi and Tolnaftate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tolnaftate and Divi-divi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Divi-divi at all — not against Tolnaftate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Divi-divi safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Questions About Divi-divi or Tolnaftate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Divi-divi or Tolnaftate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Tolnaftate
This page covers Divi-divi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolnaftate page lists 20 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 12 minor.
From our pharmacist’s overview on the Tolnaftate page
“For anyone using tolnaftate (Tinactin), the antifungal in athlete's foot creams and sprays, activated charcoal is the interaction to understand before all others. It holds the only major rating among the 20 ingredients on file, since charcoal binds many medicines and can lower how much reaches the body, even drugs not given by mouth.”
Reviewed by 2 · Jul 18, 2026
Taking Divi-divi as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing Divi-divi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Divi-divi. Even though Divi-divi itself has no known interaction with Tolnaftate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Divi-divi and Tolnaftate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#952 of 1,452 supplements looked up here in the last 7 days
#2,625 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Divi-divi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Divi-divi reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Divi-divi and Tolnaftate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Divi-divi
What is Divi-divi?
- Source of tannins for tanning leather
- Traditional astringent for skin
- Mouth and throat irritation (traditional gargles)
- Wound and sore care (folk use)
- Mild digestive complaints (folk use)
Divi-divi is a tropical tree whose tannin-rich seed pods have long been used in leather tanning and in traditional folk remedies, mostly as an astringent. There is very little modern human research to support any health benefit, so it should not be relied on to treat any medical condition. If you are considering it, talk with a pharmacist or doctor first.
Caesalpinia coriaria · Fabaceae · Seed pods (and sometimes bark) · Powdered pod extract, decoctions, and traditional topical preparations
An interaction check asks whether these two react with each other — it does not ask whether Divi-divi is a good idea for someone in your situation. Here is what our Divi-divi record says about it on its own.
Divi-divi: dosing
There is no established or standardized medicinal dose for divi-divi. Traditional preparations vary widely and are not measured in a consistent way.If you choose to use a product that contains divi-divi, follow the directions on the label and do not exceed the suggested amount.
From our Divi-divi monograph — the full record covers uses, side effects and every documented interaction.
About Tolnaftate
What Is Tolnaftate Used For?
Brand name: Tinactin
Tolnaftate treats common fungal skin infections — specifically athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It also helps relieve the itching, cracking, burning, scaling, redness, and soreness that come with these infections.
Several products also help prevent athlete's foot from coming back with regular daily use. Note that tolnaftate is not effective on the scalp or nails — though some patch products are applied around the nail and cuticle area to address skin surrounding the nail.
Most-Reported Side Effects for Tolnaftate
From FAERS, the FDA’s public side-effect reporting system (1,403 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Divi-divi
Browse every other medication we’ve checked against Divi-divi — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Divi-divi against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Divi-divi list.
Divi-divi References
The 1 sources that drive our Divi-divi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Divi-divi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Tannins — MedlinePlus / NIH Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Divi-divi and Tolnaftate Together: Common Questions
Is it safe to take Divi-divi with Tolnaftate?
Does Tolnaftate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Tolnaftate and Divi-divi?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.