Drug & supplement interaction

European Buckthorn + Dextromethorphan, Methscopolamine, Phenylephrine

Dextromethorphan, Methscopolamine, Phenylephrine brand name: DA Chewable.

No Known Interaction
Medically reviewed by · Updated October 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan, Methscopolamine, Phenylephrine and European Buckthorn in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

European Buckthorn safety at a glance

European Buckthorn overall Use caution It is a harsh stimulant laxative and raw berries can be toxic, so use only with professional guidance.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan, Methscopolamine, Phenylephrine and European Buckthorn? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dextromethorphan, Methscopolamine, Phenylephrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextromethorphan, Methscopolamine, Phenylephrine is filed under 10 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. European Buckthorn has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and stimulant laxatives (moderate) — and none of Dextromethorphan, Methscopolamine, Phenylephrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

European Buckthorn Does Interact With Other Medications

European Buckthorn has 1 major, 98 moderate known drug interactions in our database — Dextromethorphan, Methscopolamine, Phenylephrine isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 98 No known interaction 2,731 (incl. Dextromethorphan, Methscopolamine, Phenylephrine)
Taking anything else?

Check Another of Your Medications Against European Buckthorn

Covers the 2,830 medications we’ve checked against European Buckthorn. Pick one to open its full report.

What to actually watch for

What European Buckthorn Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan, Methscopolamine, Phenylephrine. It is the side-effect record for European Buckthorn on its own, from the licensed Natural Medicines monograph. If something new turns up after you add European Buckthorn, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on Additional detail

    “Orally, European buckthorn seems to be well tolerated, short term. It can cause abdominal pain, cramps, or watery diarrhea (12). Chronic use or abuse of the berry can lead to potassium depletion, albuminuria, and hematuria. Potassium depletion can lead to disturbed heart function and muscle weakness (2).”

    European Buckthorn · Natural Medicines adverse-effect record, reported in albuminuria.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    3. 6138. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  • Low potassium Worth acting on Additional detail

    “Orally, European buckthorn might have adverse effects.

    Most Common Adverse Effects:

    Orally: Abdominal pain, cramps, watery diarrhea.

    Serious Adverse Effects (Rare):

    Orally: Albuminuria, hematuria, potassium depletion.”

    European Buckthorn · Natural Medicines adverse-effect record, reported in abdominal pain.

  • Stomach pain / Diarrhea Additional detail

    Recorded for European Buckthorn in the same Natural Medicines adverse-effect record shown under Low potassium above.

Everything above comes from the Natural Medicines adverse-effect record for European Buckthorn — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan, Methscopolamine, Phenylephrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan, Methscopolamine, Phenylephrine.

Special populations

European Buckthorn in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Dextromethorphan, Methscopolamine, Phenylephrine

This page covers European Buckthorn only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan, Methscopolamine, Phenylephrine page lists 220 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 166 moderate · 44 minor.

From our pharmacist’s overview on the Dextromethorphan, Methscopolamine, Phenylephrine page

“Dextromethorphan with methscopolamine and phenylephrine (DA Chewable) packs a cough suppressant, a drying agent, and a decongestant into one tablet, which gives supplements several distinct ways to cause trouble, so I treat this as a list deserving real caution. Grapefruit can drive levels of the drug up by blocking its breakdown, St.”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan, Methscopolamine, Phenylephrine interaction page

One more smart check

Taking European Buckthorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing European Buckthorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides European Buckthorn. Even though European Buckthorn itself has no known interaction with Dextromethorphan, Methscopolamine, Phenylephrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement European Buckthorn
Steady interest

#962 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextromethorphan, Methscopolamine, Phenylephrine
Top 10%

#244 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every European Buckthorn reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine records this page draws on were last updated October 6, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About European Buckthorn

What is European Buckthorn?

  • Constipation
  • Occasional laxative use
  • Digestive complaints
  • Traditional 'detox' remedies

European Buckthorn is a shrub whose bark and berries contain compounds that act as a strong, irritant-type laxative. Because it can cause cramping, fluid and electrolyte loss, and the berries can be toxic if eaten raw, it is rarely recommended today and safer constipation options are usually preferred. Talk to a pharmacist or doctor before using it.

Rhamnus cathartica · Rhamnaceae · Bark and berries (fruit) · Dried bark, tinctures, teas, and liquid extracts (rarely sold as a modern standardized supplement)

An interaction check asks whether these two react with each other — it does not ask whether European Buckthorn is a good idea for someone in your situation. Here is what our European Buckthorn record says about it on its own.

European Buckthorn: dosing

There is no well-established, standardized dose for European Buckthorn supplements, and the strength of homemade preparations can vary widely. This is one reason it is hard to use safely.If a product is used at all, it should be a properly labeled commercial preparation, taken exactly as directed and only for short-term use.

From our European Buckthorn monograph — the full record covers uses, side effects and every documented interaction.

Read the full European Buckthorn monograph & all interactions
Keep checking

Other Drugs & European Buckthorn

Browse every other medication we’ve checked against European Buckthorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
98Moderate
0Minor
2,730No known interaction
1 Major 98 Moderate 2,730 No interaction
Major

1 interaction

Moderate

98 interactions

Showing 60 of 98 moderate interactions — see all 98 on the European Buckthorn page.

No interaction 2,730 drugs checked — show the list

We also checked European Buckthorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full European Buckthorn list.

See the full European Buckthorn interactions page
See every supplement checked against Dextromethorphan, Methscopolamine, Phenylephrine, ranked by severity
Evidence & sources

European Buckthorn References

The 5 references that drive our European Buckthorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. American Herbal Products Association's Botanical Safety Handbook, Second Edition. Ed. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine Together: Common Questions

Is it safe to take European Buckthorn with Dextromethorphan, Methscopolamine, Phenylephrine?
We do not list a known interaction between European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the European Buckthorn and Dextromethorphan, Methscopolamine, Phenylephrine combination checked?
Interactions in our licensed database are recorded against drug classes. Dextromethorphan, Methscopolamine, Phenylephrine is filed under 10 classifications, and European Buckthorn has documented interactions with 4 drug classes — none of Dextromethorphan, Methscopolamine, Phenylephrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does European Buckthorn interact with any other medications?
Yes. European Buckthorn has 99 documented drug interactions in our database — Dextromethorphan, Methscopolamine, Phenylephrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dextromethorphan, Methscopolamine, Phenylephrine interact with any supplements?
Yes. Dextromethorphan, Methscopolamine, Phenylephrine has documented interactions with 220 supplements in our database — European Buckthorn is not one of them. The Dextromethorphan, Methscopolamine, Phenylephrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

European Buckthorn monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan, Methscopolamine, Phenylephrine supplement interactions Every supplement checked against Dextromethorphan, Methscopolamine, Phenylephrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan, Methscopolamine, Phenylephrine and European Buckthorn?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.