Eurycoma Longifolia - Arcalyst (Rilonacept) Interaction
Herbal: Eurycoma Longifolia
Also Known As: Akar Pasak Bumi, Ali's Umbrella, Ali's Walking Stick, Bedara Pahit, Canne d'Ali, Cay ba binh, Eurycoma, Eurycoma Longifolia Jack, Ian-don, Jelaih, Long Jack, Longjack, Malaysian Ginseng, Pasak Bumi, Payung Ali, Pokok Jelas, Pokok Syurga, Setunjang Bumi, Tho Nan, Tongkat Ali
Drug: Rilonacept
Brand names:
Arcalyst

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Rilonacept and Eurycoma Longifolia. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Although there is no known interaction in this case, Eurycoma longifolia, most commonly known as Tongkat Ali, does have some potential interactions that are important to be aware of.
For example, it may interact with the following:
- CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
- CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
- CYTOCHROME P450 2A6 (CYP2A6) SUBSTRATES
- Propranolol
- Testosterone
Tongkat Ali has been reported to inhibit certain metabolizing enzymes in the liver (the ones mentioned above) and therefore, may increase the levels of substances metabolized by those enzymes. This could potentially affect the way these substances work or how long they stay in your system.
In regard to propranolol, some studies show that Tongkat Ali decreases how well propranolol is absorbed in the gut and could reduce its effects. It is not known if separating administration will prevent this interaction/
Lastly, testosterone, Tongkat Ali may theoretically further increase levels of testosterone, a hormone responsible for various functions in the body. You should be cautious combining the two.
- Dr. Brian Staiger, PharmDEurycoma Longifolia Overview

Rilonacept Overview
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Rilonacept injection is used to treat cryopyrin-associated periodic syndromes (CAPS; inherited conditions in which the body attacks its own tissues causing inflammation, joint and muscle pain, rash or other skin lesions, fever and chills, eye redness or pain, and fatigue), including familial cold autoinflammatory syndrome (FCAS), and Muckle-Wells syndrome (MWS) in adults and children 12 years of age or older. Rilonacept injection is also used to treat deficiency of interleukin-1 receptor antagonist (DIRA; a disorder in which the body attacks its own tissues causing inflammation and damages bones, nervous system, skin, lungs, liver, and joints) in adults and children who weigh at least 22 pounds (10 kg). Rilonacept injection is also used to treat recurrent pericarditis (swelling of the sac around the heart) and also to prevent the return of pericarditis in adults and children 12 years of age or older. Rilonacept is in a class of medications called interleukin antagonists. It works by blocking the activity of interleukin, a substance in the body that causes inflammation.
Eurycoma Longifolia - More Interactions
Eurycoma Longifolia interacts with 247 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.