Drug & supplement interaction

Frostwort + Balsalazide Disodium

Balsalazide Disodium brand names: Colazal, Giazo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Frostwort and Balsalazide Disodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Frostwort and Balsalazide Disodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Balsalazide Disodium and Frostwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Frostwort at all — not against Balsalazide Disodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Frostwort safety at a glance

Frostwort overall Not established There is very little modern safety data on frostwort in humans.
Pregnancy Avoid Safety is not established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information exists, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Balsalazide Disodium and Frostwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Balsalazide Disodium’s Own FDA Label Lists

This is not an interaction — none of it involves Frostwort. These are the most notable effects listed in the ADVERSE REACTIONS section of Balsalazide Disodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Kidney stones Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Sun sensitivity

Showing the 10 most notable of 31 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Balsalazide Disodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 505 voluntary FDA FAERS reports for Balsalazide Disodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Frostwort’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Frostwort side to compare — that is a limit of the record, not a statement that Frostwort has no side effects.

Everything else you take

See Every Supplement That Interacts With Balsalazide Disodium

This page covers Frostwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Balsalazide Disodium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Balsalazide Disodium page

“Balsalazide Disodium (Colazal, Giazo) only works if it reaches the colon intact, and the 17 supplement interactions on file all threaten that journey, so this list deserves real care. Every entry comes down to absorption of the oral dose.”

Reviewed by 2 · Jul 18, 2026

Open the Balsalazide Disodium interaction page

How much people look this up

Where Frostwort and Balsalazide Disodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Frostwort
Top half

#602 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Balsalazide Disodium
Top half

#1,171 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Frostwort is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frostwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Frostwort and Balsalazide Disodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Frostwort

What is Frostwort?

  • Sore throat and mouth irritation
  • Diarrhea
  • Skin conditions and ulcers (topical)
  • Scrofula (historical/traditional use)
  • General astringent tonic

Frostwort is a North American wildflower used in traditional and folk herbal medicine, mainly as an astringent for sore throats, diarrhea, and skin problems. There is very little modern scientific research to confirm that it works or to define a safe dose, so it should be used cautiously and only after talking with a healthcare professional.

Helianthemum canadense · Cistaceae · Whole plant (leaves and aerial parts) · Dried herb, tea (infusion), tincture, sometimes topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Frostwort is a good idea for someone in your situation. Here is what our Frostwort record says about it on its own.

Frostwort: dosing

There is no established or standardized dose for frostwort. Traditional use varied widely and was not based on measured, tested amounts.If you choose to use a frostwort product, follow the directions on the product label and do not exceed them.

From our Frostwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Frostwort monograph & all interactions
Medication

About Balsalazide

What Is Balsalazide Used For?

Brand names: Colazal, Giazo

Balsalazide disodium capsules (sold as Balsalazide Disodium and Colazal) are used to treat mildly to moderately active ulcerative colitis — a condition where the lining of the colon becomes inflamed and causes symptoms like diarrhea, rectal bleeding, and abdominal pain. This use is approved for adults and for children ages 5 through 17.

The established treatment period is up to 8 weeks in children (ages 5–17) and up to 12 weeks in adults. Safety and effectiveness beyond those time frames have not been established in clinical trials.

Most-Reported Side Effects for Balsalazide Disodium

From FAERS, the FDA’s public side-effect reporting system (505 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 43 reports
Injection site pain 39 reports
Colitis ulcerative 32 reports
Fatigue 31 reports
Arthralgia 30 reports
See full Balsalazide drug information
Keep checking

Other Drugs & Frostwort

Browse every other medication we’ve checked against Frostwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Frostwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frostwort list.

See the full Frostwort interactions page
See every supplement checked against Balsalazide Disodium, ranked by severity
Evidence & sources

Frostwort References

The 1 sources that drive our Frostwort monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Frostwort is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Frostwort and Balsalazide Disodium Together: Common Questions

Is it safe to take Frostwort with Balsalazide Disodium?
We do not list a known interaction between Frostwort and Balsalazide Disodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Balsalazide Disodium interact with any supplements?
Yes. Balsalazide Disodium has documented interactions with 17 supplements in our database — Frostwort is not one of them. The Balsalazide Disodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Frostwort monograph Uses, safety profile, and every drug interaction in one place Balsalazide drug information The full plain-English guide to this medication Balsalazide Disodium supplement interactions Every supplement checked against Balsalazide Disodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Balsalazide Disodium and Frostwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.