Drug & supplement interaction

Gamma Butyrolactone (gbl) + Liotrix

Liotrix brand names: Euthroid 3, Euthroid 1/2, Euthroid 1.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Gamma Butyrolactone (gbl) and Liotrix in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Liotrix states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Gamma Butyrolactone (gbl) and Liotrix

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liotrix and Gamma Butyrolactone (gbl) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamma Butyrolactone (gbl) safety at a glance

Gamma Butyrolacton... overall Avoid GBL is a toxic, illegal substance that can cause coma and death; it should never be consumed.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liotrix and Gamma Butyrolactone (gbl)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Liotrix

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liotrix is filed under 2 classifications — thyroid hormone, oral drugs. Gamma Butyrolactone (gbl) has documented interactions with 10 drug classes — the most serious being alcohol (ethanol) (moderate), amphetamines (moderate) and anticonvulsants (moderate) — and none of Liotrix’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gamma Butyrolactone (gbl) Does Interact With Other Medications

Gamma Butyrolactone (gbl) has 271 moderate known drug interactions in our database — Liotrix isn’t one of them. If you take anything else, check it against the full list below.

Moderate 271 No known interaction 2,559 (incl. Liotrix)
Taking anything else?

Check Another of Your Medications Against Gamma Butyrolactone (gbl)

Covers the 2,830 medications we’ve checked against Gamma Butyrolactone (gbl). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gamma Butyrolactone (gbl) and Liotrix May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Gamma Butyrolactone (gbl)

    “Orally, GBL can cause fainting, seizures, and severe central nervous system depression. In many cases, unconsciousness or coma have been reported.

    Withdrawal symptoms have been reported in people who ingest diluted products containing almost pure GBL every few hours. Withdrawal symptoms can start within 2-72 hours and can last for up to 15 days.”

    Gamma Butyrolactone (gbl) · Natural Medicines adverse-effect record, reported in depression.

    6 sources cited
    1. 665. LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.
    2. 682. FDA. FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Talk Paper, 21 January 1999.
    3. 1430. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
    4. 93819. Bosch OG, Eisenegger C, Gertsch J, et al. Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology. 2015 Dec;62:1-10. PubMed
    5. 95127. Corkery JM, Loi B, Claridge H, et al. Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use. Neurosci Biobehav Rev 2015;53:52-78. PubMed
    6. 95129. Eiden C, Capdevielle D, Deddouche C, et al. Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal. J Addict Med 2011;5(4):302-3. PubMed

    Liotrix

    Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

  • Sweating / Trouble sleeping / Fever Additional detail

    Gamma Butyrolactone (gbl)

    Recorded for Gamma Butyrolactone (gbl) in the same Natural Medicines adverse-effect record shown under Seizures above.

    Liotrix

    Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Gamma Butyrolactone (gbl)

    “Orally, GBL can cause bradycardia, hypotension, tachycardia, and cardiac arrest.

    Consistent use of GBL followed by abrupt discontinuation is associated with withdrawal symptoms, including tachycardia and hypertension.”

    Gamma Butyrolactone (gbl) · Natural Medicines adverse-effect record, reported in cardiac arrest.

    6 sources cited
    1. 665. LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.
    2. 682. FDA. FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Talk Paper, 21 January 1999.
    3. 1430. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
    4. 95127. Corkery JM, Loi B, Claridge H, et al. Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use. Neurosci Biobehav Rev 2015;53:52-78. PubMed
    5. 95128. Dargan PI, Button J, Davies S, et al. The first reported UK fatality related to gamma-butyrolactone (GBL) ingestion. J R Soc Med 2009;102(12):546-7.
    6. 95130. Heytens L, Neels H, Van Regenmortel N, et al. Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication. Ann Clin Biochem 2015;52(Pt 2):283-7. PubMed

    Liotrix

    Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Gamma Butyrolactone (gbl)

    “Orally, GBL can cause mental changes, such as agitation, combativeness, and amnesia.

    Withdrawal symptoms have been reported in people who ingest diluted products containing almost pure GBL every few hours. Withdrawal symptoms can start within 2-72 hours and can last up to 15 days.”

    Gamma Butyrolactone (gbl) · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 665. LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.
    2. 682. FDA. FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Talk Paper, 21 January 1999.
    3. 1430. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
    4. 95118. Bhattacharya IS, Watson F, Bruce M. A case of ?-butyrolactone associated with severe withdrawal delirium and acute renal failure. Eur Addict Res 2011;17(4):169-71. PubMed
    5. 95129. Eiden C, Capdevielle D, Deddouche C, et al. Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal. J Addict Med 2011;5(4):302-3. PubMed
    6. 10375. Schneir AB, Ly BT, Clark RF. A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. J Emerg Med 2001;21:31-3.. PubMed

    Liotrix

    Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Gamma Butyrolactone (gbl)

    “Orally, GBL can cause bowel incontinence and vomiting.

    Consistent use of GBL followed by abrupt discontinuation is associated with withdrawal symptoms, including nausea and vomiting.”

    Gamma Butyrolactone (gbl) · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    6 sources cited
    1. 665. LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.
    2. 682. FDA. FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Talk Paper, 21 January 1999.
    3. 1430. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
    4. 93819. Bosch OG, Eisenegger C, Gertsch J, et al. Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology. 2015 Dec;62:1-10. PubMed
    5. 95130. Heytens L, Neels H, Van Regenmortel N, et al. Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication. Ann Clin Biochem 2015;52(Pt 2):283-7. PubMed
    6. 95118. Bhattacharya IS, Watson F, Bruce M. A case of ?-butyrolactone associated with severe withdrawal delirium and acute renal failure. Eur Addict Res 2011;17(4):169-71. PubMed

    Liotrix

    Listed in the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed ›

Reported for Gamma Butyrolactone (gbl) but not commonly for Liotrix: dependence or withdrawal symptoms, kidney problems, hallucinations and severe muscle breakdown.

Effects for Liotrix come from the ADVERSE REACTIONS section of its FDA label; effects for Gamma Butyrolactone (gbl) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Gamma Butyrolactone (gbl) in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Liotrix Products Have a Food Rule — Gamma Butyrolactone (gbl) Should Not Break It

At least one FDA label for a product containing Liotrix says to take it on an empty stomach. Most supplements — Gamma Butyrolactone (gbl) included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Liotrix on its own and move Gamma Butyrolactone (gbl) to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Liotrix products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Liotrix Is Prescribed For, and What Gamma Butyrolactone (gbl) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Liotrix is a prescription medicine with approved uses on its FDA label. Gamma Butyrolactone (gbl) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Gamma Butyrolactone (gbl) has been studied for:

  • Depression studied, not established Gamma Butyrolactone (gbl) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Gamma Butyrolactone (gbl) for depression

    Although there has been interest in using oral GBL for depression, there is insufficient reliable information about the clinical effects of GBL for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Liotrix on your own; if you are taking Gamma Butyrolactone (gbl) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Liotrix

This page covers Gamma Butyrolactone (gbl) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liotrix page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liotrix page

“Liotrix (Euthroid) combines both thyroid hormones, and since steady hormone levels are the entire point of treatment, this list deserves a slow, serious read. Most entries fall into two camps: twenty-one ingredients act on the hormone itself, some boosting it and others blunting it, while another seventeen change how well the dose is a…”

Reviewed by 2 · Jul 18, 2026

Open the Liotrix interaction page

How much people look this up

Where Gamma Butyrolactone (gbl) and Liotrix Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamma Butyrolactone (gbl)
Steady interest

#1,208 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liotrix
Steady interest

#2,306 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gamma Butyrolactone (gbl) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Gamma Butyrolactone (gbl) and Liotrix records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamma Butyrolactone (gbl)

What is Gamma Butyrolactone (gbl)?

Gamma Butyrolactone (gbl)
  • Recreational intoxication and euphoria
  • Relaxation and sedation
  • Sleep aid (misused)
  • Bodybuilding/muscle building claims (unproven)
  • Industrial solvent and cleaner

Gamma butyrolactone (GBL) is a toxic industrial solvent, not a dietary supplement, and the body converts it into GHB, a powerful and dangerous sedative. It is illegal to sell or possess for human use in the United States, has no proven medical or supplemental benefit, and can cause coma, seizures, and death. Do not take GBL — if you are seeking help for sleep, anxiety, or substance use, talk to a doctor or pharmacist.

Not applicable (synthetic industrial chemical) · Liquid (illicitly sold); used industrially as a solvent

An interaction check asks whether these two react with each other — it does not ask whether Gamma Butyrolactone (gbl) is a good idea for someone in your situation. Here is what our Gamma Butyrolactone (gbl) record says about it on its own.

Gamma Butyrolactone (gbl): dosing

There is no safe or recommended dose of GBL. It is not a supplement, it is illegal to sell for human use, and any amount can be dangerous because it converts into the potent sedative GHB.No pharmacist or doctor should recommend taking GBL.

From our Gamma Butyrolactone (gbl) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamma Butyrolactone (gbl) monograph & all interactions
Medication

About Liotrix

What Is Liotrix Used For?

Brand names: Euthroid 3, Euthroid 1/2, Euthroid 1

  • Liotrix is used to treat hypothyroidism (a condition that results when the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyroidism include lack of energy, depression, constipation, weight gain, hair loss, dry skin, dry coarse hair, muscle cramps, decreased concentration, aches and pains, swelling of the legs, and increased sensitivity to cold. When taken correctly, liotrix can reverse these symptoms. Liotrix is also used to treat goiter (enlarged thyroid gland). This medication is also used to test for hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormone). Liotrix is in a class of medications called thyroid agents. It works by supplying the thyroid hormones normally produced by the body.

See full Liotrix drug information
Keep checking

Other Drugs & Gamma Butyrolactone (gbl)

Browse every other medication we’ve checked against Gamma Butyrolactone (gbl) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
271Moderate
0Minor
2,558No known interaction
271 Moderate 2,558 No interaction
Moderate

271 interactions

Showing 60 of 271 moderate interactions — see all 271 on the Gamma Butyrolactone (gbl) page.

No interaction 2,558 drugs checked — show the list

We also checked Gamma Butyrolactone (gbl) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,558 medications checked with no known interaction — see the full Gamma Butyrolactone (gbl) list.

See the full Gamma Butyrolactone (gbl) interactions page
See every supplement checked against Liotrix, ranked by severity
Evidence & sources

Gamma Butyrolactone (gbl) References

The 28 references that drive our Gamma Butyrolactone (gbl) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Soderling E, Le Bell A, Kirstila V, Tenovuo J. Betaine-containing toothpaste relieves subjective symptoms of dry mouth. Acta Odontol Scand 1998;56:65-9.
  2. LoVecchio F, Curry SC, Bagnasco T. Butyrolactone-induced central nervous system depression after ingestion of RenewTrient, a dietary supplement. N Engl J Med 1998;339:847-8.
  3. FDA. FDA warns about products containing gamma butyrolactone or GBL and asks companies to issue a recall. Talk Paper, 21 January 1999.
  4. Anon. Adverse events associated with ingestion of gamma-butyrolactone--Minnesota, New Mexico, and Texas, 1998-1999. MMWR Morb Mortal Wkly Rep 1999;48:137-40.
  5. Harrington RD, Woodward JA, Hooton TM, et al. Life-threatening interactions between HIV-1 protease inhibitors and the illicit drugs MDMA and gamma-hydroxybutyrate. Arch Intern Med 1999;159:2221-4.
  6. Anon. FDA alert on misuse of consumer products containing GHB, GBL and BD. Food and Drug Administration, Rockville, MD. June 15, 1999.
  7. Anon. Important message for health professionals: Report serious adverse events associated with dietary supplements containing GBL, GHB or BD. Food and Drug Administration, Rockville, MD. August 25, 1999. Available at: http://vm.cfsan.fda.gov/~dms/mwg
  8. Anon. Multistate outbreak of poisonings associated with illicit use of gamma hydroxy butyrate. JAMA 1991;265:447-8. DOI
  9. Carotenuto A, De Feo V, Fattorusso E, et al. The flavonoids of Allium ursinum. Phytochem 1996;41:531-6. PubMed
  10. FDA Talk Paper. FDA Warns About GBL-Related Products. 1999. Available at: vm.cfsan.fda.gov/~lrd/tpgbl2.html
  11. Ferrara SD, Tedeschi L, Frison G, Rossi A. Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication. J Forensic Sci 1995;40:501-4. DOI
  12. Schneir AB, Ly BT, Clark RF. A case of withdrawal from the GHB precursors gamma-butyrolactone and 1,4-butanediol. J Emerg Med 2001;21:31-3.. PubMed
  13. Sivilotti ML, Burns MJ, Aaron CK, Greenberg MJ. Pentobarbital for severe gamma-butyrolactone withdrawal. Ann Emerg Med 2001;38:660-5.. PubMed
  14. Bosch OG, Eisenegger C, Gertsch J, et al. Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology. 2015 Dec;62:1-10. PubMed
  15. Thai D, Dyer JE, Benowitz NL, Haller CA. Gamma-hydroxybutyrate and ethanol effects and interactions in humans. J Clin Psychopharmacol. 2006 Oct;26(5):524-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gamma Butyrolactone (gbl) and Liotrix Together: Common Questions

Is it safe to take Gamma Butyrolactone (gbl) with Liotrix?
We do not list a known interaction between Gamma Butyrolactone (gbl) and Liotrix. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gamma Butyrolactone (gbl) and Liotrix have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Gamma Butyrolactone (gbl) and Liotrix at the same time of day?
At least one FDA label for a product containing Liotrix says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Liotrix on its own and move Gamma Butyrolactone (gbl) to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Are Gamma Butyrolactone (gbl) and Liotrix used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gamma Butyrolactone (gbl) in each. That is a conversation for your prescriber, especially if Liotrix is being adjusted to a target.
How was the Gamma Butyrolactone (gbl) and Liotrix combination checked?
Interactions in our licensed database are recorded against drug classes. Liotrix is filed under 2 classifications, and Gamma Butyrolactone (gbl) has documented interactions with 10 drug classes — none of Liotrix's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gamma Butyrolactone (gbl) interact with any other medications?
Yes. Gamma Butyrolactone (gbl) has 271 documented drug interactions in our database — Liotrix is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Liotrix interact with any supplements?
Yes. Liotrix has documented interactions with 38 supplements in our database — Gamma Butyrolactone (gbl) is not one of them. The Liotrix interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gamma Butyrolactone (gbl) monograph Uses, safety profile, and every drug interaction in one place Liotrix drug information The full plain-English guide to this medication Liotrix supplement interactions Every supplement checked against Liotrix, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 28 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.