Drug & supplement interaction

Gardenia + Goserelin

Goserelin brand name: Zoladex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gardenia and Goserelin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Gardenia and Goserelin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Goserelin and Gardenia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gardenia safety at a glance

Gardenia overall Use caution Human safety data are limited, and large or long-term amounts have not been well studied.
Pregnancy Avoid Not enough safety information is available, so it is best to avoid it during pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid it while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Goserelin and Gardenia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Goserelin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Goserelin is filed under a single classification — oral drugs. Gardenia has documented interactions with 1 drug class — the most serious being stimulant laxatives (moderate) — and none of Goserelin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gardenia Does Interact With Other Medications

Gardenia has 21 moderate known drug interactions in our database — Goserelin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 21 No known interaction 2,809 (incl. Goserelin)
Taking anything else?

Check Another of Your Medications Against Gardenia

Covers the 2,830 medications we’ve checked against Gardenia. Pick one to open its full report.

What to actually watch for

What Gardenia Itself Has Been Linked To

This is not an interaction — nothing below involves Goserelin. It is the side-effect record for Gardenia on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Gardenia, this list is the first place to look.

  • Stomach pain / Vomiting / Nausea Additional detail

    “Orally, there are case reports of mesenteric phlebosclerosis, a thickening of the walls of the intestine and mesenteric veins, which can lead to obstruction and occlusion. Typical presenting symptoms are paroxysmal abdominal pain with nausea and vomiting, and imaging studies reveal thickening and stiffening of the walls of the ascending and transverse colon, with dark purple discoloration of the colonic and rectal mu…”

    Gardenia · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 112954. Tong T, Fu J, Kong Y. Recurrent Abdominal Pain in a 61-Year-Old Woman. Gastroenterology 2023;164(6):887-890. PubMed
  • A skin rash Additional detail

    “Topically, exposure to gardenia fruit extract or the whole plant has been associated with allergic contact dermatitis.

    Orally, there is a case report of blue-gray skin pigmentation associated with taking a product containing the extracts of gardenia fruit, phellodendron bark, and licorice for 7 years in a 77-year-old female.”

    Gardenia · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 26518. Kubo, Y., Nonaka, S., and Yoshida, H. Allergic contact dermatitis from gardenia fruit. Contact Dermatitis 1990;22(2):65-7. PubMed
    2. 49078. Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers. Contact Dermatitis 1998;39(4):166-170. PubMed
    3. 102698. Mizawa M, Andoh T, Shimizu T. Gardenia fruit-related blue-gray skin pigmentation. JAMA Dermatol. 2020. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Gardenia — expand a row for the licensed statement it rests on. We haven’t matched Goserelin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Goserelin.

Everything else you take

See Every Supplement That Interacts With Goserelin

This page covers Gardenia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Goserelin page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Goserelin page

“Goserelin (Zoladex) is given as a small implant under the skin, usually for prostate cancer, certain breast cancers, or endometriosis, and I would want anyone on it to read this list with real attention. All 17 flagged ingredients raise the same basic concern, changing how drugs are absorbed or retained, and the single major-rated one…”

Reviewed by 2 · Jul 18, 2026

Open the Goserelin interaction page

One more smart check

Taking Gardenia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 240 real supplement products containing Gardenia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gardenia. Even though Gardenia itself has no known interaction with Goserelin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gardenia and Goserelin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gardenia
Top half

#531 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Goserelin
Steady interest

#1,832 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gardenia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gardenia and Goserelin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gardenia

What is Gardenia?

Gardenia
  • Liver and digestive complaints
  • Fever and inflammation
  • Anxiety, restlessness, and trouble sleeping
  • Blood pressure and blood sugar support (traditional)
  • Natural food and fabric coloring

Gardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are interesting, strong human evidence for its health benefits is lacking, so talk with your pharmacist or doctor before using it as a supplement.

Gardenia jasminoides · Rubiaceae · Fruit (the dried ripe fruit, called zhi zi in Chinese medicine), and sometimes the flower · Dried fruit, powders, capsules, teas/decoctions, liquid extracts, and as a natural food coloring (gardenia yellow/blue)

An interaction check asks whether these two react with each other — it does not ask whether Gardenia is a good idea for someone in your situation. Here is what our Gardenia record says about it on its own.

Gardenia: dosing

There is no standardized, well-established dose for gardenia supplements. Traditional formulas use the dried fruit in decoctions, but products sold today vary widely in strength and form.If you choose to use a gardenia product, follow the directions on the label and do not exceed the recommended amount.

From our Gardenia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gardenia monograph & all interactions
Medication

About Goserelin Implant

What Is Goserelin Implant Used For?

Brand name: Zoladex

  • Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. It is also used to treat advanced breast cancer in certain women. It is also used to manage endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms) and to help with the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.

Most-Reported Side Effects for Goserelin

From FAERS, the FDA’s public side-effect reporting system (13,351 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 1,340 reports
Fatigue 886 reports
Metastases to bone 698 reports
Neutropenia 656 reports
Nausea 600 reports
See full Goserelin Implant drug information
Keep checking

Other Drugs & Gardenia

Browse every other medication we’ve checked against Gardenia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
21Moderate
0Minor
2,808No known interaction
21 Moderate 2,808 No interaction
Moderate

21 interactions

No interaction 2,808 drugs checked — show the list

We also checked Gardenia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,808 medications checked with no known interaction — see the full Gardenia list.

See the full Gardenia interactions page
See every supplement checked against Goserelin, ranked by severity
Evidence & sources

Gardenia References

The 5 references that drive our Gardenia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kubo, Y., Nonaka, S., and Yoshida, H. Allergic contact dermatitis from gardenia fruit. Contact Dermatitis 1990;22(2):65-7. PubMed
  2. Yamauchi, K., Fujimoto, N., Kuwano, S., Inouye, H., and Inoue, K. The mechanism of purgative action of geniposide, an iridoid glucoside of the fruit of Gardenia, in mice. Planta Med 1976;30(1):39-47.
  3. Paulsen, E., Skov, P. S., and Andersen, K. E. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers. Contact Dermatitis 1998;39(4):166-170. PubMed
  4. Mizawa M, Andoh T, Shimizu T. Gardenia fruit-related blue-gray skin pigmentation. JAMA Dermatol. 2020. PubMed
  5. Tong T, Fu J, Kong Y. Recurrent Abdominal Pain in a 61-Year-Old Woman. Gastroenterology 2023;164(6):887-890. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gardenia and Goserelin Together: Common Questions

Is it safe to take Gardenia with Goserelin?
We do not list a known interaction between Gardenia and Goserelin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Gardenia and Goserelin combination checked?
Interactions in our licensed database are recorded against drug classes. Goserelin is filed under 1 classification, and Gardenia has documented interactions with 1 drug class — none of Goserelin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gardenia interact with any other medications?
Yes. Gardenia has 21 documented drug interactions in our database — Goserelin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Goserelin interact with any supplements?
Yes. Goserelin has documented interactions with 17 supplements in our database — Gardenia is not one of them. The Goserelin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gardenia monograph Uses, safety profile, and every drug interaction in one place Goserelin Implant drug information The full plain-English guide to this medication Goserelin supplement interactions Every supplement checked against Goserelin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Goserelin and Gardenia?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.