Garlic - Acetaminophen, Doxylamine, Pseudoephedrine Interaction
Herbal: Garlic
Also Known As: Allium sativum, Aged Black Garlic Extract, Aged Garlic Extract, Ail, Ail Blanc, Ail Cultive, Ail Rocambole, Ajo, Alho, Allii Sativi Bulbus, Allium, Angio D'India, Black Garlic, Camphor Of The Poor, Clove Garlic, Common Garlic, Da Suan, Echte Rokkenbolle, Echter Knoblauch
Drug: Acetaminophen, Doxylamine, Pseudoephedrine
Brand names:
Ex Strength Tylenol Sinus Nighttime

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Acetaminophen, Doxylamine, Pseudoephedrine is classified as belonging to the following category: Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Gurley BJ, Gardner SF, Hubbard MA, et al. Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002;72:276-87..
Garlic Overview

Garlic - More Interactions
Garlic interacts with 964 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.