Germander + Doxylamine Succinate, Pyridoxine Hydrochloride
Doxylamine Succinate, Pyridoxine Hydrochloride brand names: Diclegis, Bonjesta.
We found no known interaction between Germander and Doxylamine Succinate, Pyridoxine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxylamine Succinate, Pyridoxine Hydrochloride states a food rule worth keeping to.
Germander and Doxylamine Succinate, Pyridoxine Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Doxylamine Succinate, Pyridoxine Hydrochloride and Germander in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Germander at all — not against Doxylamine Succinate, Pyridoxine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Germander safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Germander in Pregnancy & Breastfeeding
When used orally.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Doxylamine Succinate, Pyridoxine Hydrochloride Products Have a Food Rule — Germander Should Not Break It
At least one FDA label for a product containing Doxylamine Succinate, Pyridoxine Hydrochloride says to take it on an empty stomach. Most supplements — Germander included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxylamine Succinate, Pyridoxine Hydrochloride on its own and move Germander to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxylamine Succinate, Pyridoxine Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Take on an empty stomach with a glass of water [ see Clinical Pharmacology (12.3) ].
From the Dosage and Administration section of the FDA label we read for Doxylamine Succinate, Pyridoxine Hydrochloride — where that label names a specific product, the instruction is that product's. See the Doxylamine Succinate, Pyridoxine Hydrochloride drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Doxylamine Succinate, Pyridoxine Hydrochloride
This page covers Germander only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxylamine Succinate, Pyridoxine Hydrochloride page lists 46 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).
By severity: 3 major · 32 moderate · 11 minor.
From our pharmacist’s overview on the Doxylamine Succinate, Pyridoxine Hydrochloride page
“If you take doxylamine and pyridoxine (Diclegis, Bonjesta) for pregnancy nausea, this list deserves genuine care, because three of its 46 entries carry a major rating. The risk splits two ways.”
Reviewed by 2 · Jul 18, 2026
Open the Doxylamine Succinate, Pyridoxine Hydrochloride interaction page
Where Germander and Doxylamine Succinate, Pyridoxine Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,019 of 1,452 supplements looked up here in the last 7 days
#2,419 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Germander reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Germander and Doxylamine Succinate, Pyridoxine Hydrochloride records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Germander
What is Germander?
- Weight loss aids
- Digestive complaints
- Appetite stimulation
- Gout and arthritis (traditional)
- Fever and infections (traditional)
Germander is a traditional herb that was once used for weight loss and digestion, but it has been linked to serious and sometimes fatal liver damage. Because of these well-documented liver risks, germander has been banned or restricted in several countries, and we strongly advise against using it.
Teucrium chamaedrys · Lamiaceae · Above-ground parts (leaves and flowering tops) · Tea, capsules, tinctures, dried herb
An interaction check asks whether these two react with each other — it does not ask whether Germander is a good idea for someone in your situation. Here is what our Germander record says about it on its own.
Germander: dosing
There is no safe or established dose for germander. A safer, evidence-based option is almost always available.
From our Germander monograph — the full record covers uses, side effects and every documented interaction.
About Doxylamine and Pyridoxine
What Is Doxylamine and Pyridoxine Used For?
Brand names: Diclegis, Bonjesta
Doxylamine and pyridoxine is indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. This applies to the delayed-release tablets (including Diclegis and the generic doxylamine succinate and pyridoxine hydrochloride delayed-release tablets) as well as to Bonjesta, the extended-release tablet formulation.
None of these products have been studied in women with hyperemesis gravidarum (severe, persistent vomiting in pregnancy), so their use in that setting is not established.
Other Drugs & Germander
Browse every other medication we’ve checked against Germander — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Germander against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Amitriptyline ›
- Isotretinoin ›
- Methotrexate ›
- Bupropion ›
- Bendamustine ›
- Amlodipine Besylate ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Naproxen ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Germander list.
Germander References
The 5 references that drive our Germander monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris: Lavoisier Publishing, 1995. DOI
- Larrey D, Vial T, Pauwels A, et al. Hepatitis after germander (Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity. Ann Intern Med 1992;117:129-32.
- Pauwels A, Thierman-Duffaud D, Azanowsky JM, et al. [Acute hepatitis caused by wild germander. Hepatotoxicity of herbal remedies. Two cases]. Gastroenterol Clin Biol 1992;16:92-5.
- Castot A, Djezzar S, Deleau N, et al. [Pharmacovigilance off the beaten track: herbal surveillance or pharmacovigilance of medicinal plants]. Therapie 1997;52:97-103.
- Mostefa-Kara N, Pauwels A, Pines E, et al. Fatal hepatitis after herbal tea. Lancet 1992;340:674. DOI
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Germander and Doxylamine Succinate, Pyridoxine Hydrochloride Together: Common Questions
Is it safe to take Germander with Doxylamine Succinate, Pyridoxine Hydrochloride?
Should I take Germander and Doxylamine Succinate, Pyridoxine Hydrochloride at the same time of day?
Does Doxylamine Succinate, Pyridoxine Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.