Medication interaction hub

What Supplements Interact with Doxylamine Succinate, Pyridoxine Hydrochloride?

Doxylamine Succinate, Pyridoxine Hydrochloride brand names: Diclegis, Bonjesta. Every interaction below applies to the brands too.

46 Interactions 3 Major 32 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Doxylamine Succinate, Pyridoxine Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Doxylamine Succinate, Pyridoxine Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take doxylamine and pyridoxine (Diclegis, Bonjesta) for pregnancy nausea, this list deserves genuine care, because three of its 46 entries carry a major rating. The risk splits two ways. Thirty ingredients, henbane and scopolia among them, stack extra drying, sedating anticholinergic activity on top of doxylamine's own, raising the odds of severe dry mouth, blurred vision, constipation, and confusion. The other 17 change how pills absorb, and activated charcoal is the worst offender, able to soak up much of a dose before it reaches you.

Below those sit 32 moderate and 11 minor entries. A few work the opposite direction, herbs that raise acetylcholine and can blunt doxylamine so the nausea relief fades. My advice is simple. Skip the alkaloid-heavy plants entirely, and leave several hours between your dose and any charcoal or fiber product so the medicine actually gets absorbed.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 32 Minor 11 No known interaction 1,406

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Doxylamine Succinate, Pyridoxine Hydrochloride: Top Interactions at a Glance

The most significant Doxylamine Succinate, Pyridoxine Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 46 interacting ingredients — plus 1,406 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Doxylamine Succinate, Pyridoxine Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Doxylamine Succinate, Pyridoxine Hydrochloridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Henbane + Doxylamine Succinate, Pyridoxine Hydrochloridei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Scopolia + Doxylamine Succinate, Pyridoxine Hydrochloridei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Doxylamine Succinate, Pyridoxine Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 46 with a Doxylamine Succinate, Pyridoxine Hydrochloride interaction on file and 1,406 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Doxylamine Succinate, Pyridoxine Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Syrian Rue with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might decrease the effects of anticholinergic drugs.

Full Syrian Rue + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Agar with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Algin with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Black Psyllium with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Blond Psyllium with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Carob with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Karaya Gum with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Marshmallow with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Xanthan Gum with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Calabar Bean with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Deanol with Doxylamine Succinate, Pyridoxine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Activated Charcoal with Doxylamine Succinate, Pyridoxine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Henbane with Doxylamine Succinate, Pyridoxine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladon...

Full Henbane + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Scopolia with Doxylamine Succinate, Pyridoxine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of...

Full Scopolia + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Belladonna with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Belladonna may increase the risk of adverse effects when used concomitantly with anticholinergic drugs.

Full Belladonna + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Betel Nut with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.

Full Betel Nut + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Coffee Charcoal with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Datura Wrightii with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Datura wrightii contains atropine and scopolamine, as well as other tropane alkaloids with anticholinergic activity.

Full Datura Wrightii + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take European Mandrake with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Doxylamine Succinate, Pyridoxine Hydrochloride answer

Can you take Glucomannan with Doxylamine Succinate, Pyridoxine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Doxylamine Succinate, Pyridoxine Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Doxylamine Succinate, Pyridoxine Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Doxylamine Succinate, Pyridoxine Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Doxylamine Succinate, Pyridoxine Hydrochloride sits in 2 interaction categories. Open any one to see what the group means:

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Doxylamine Succinate, Pyridoxine Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Doxylamine Succinate, Pyridoxine Hydrochloride through this category.

About Doxylamine Succinate, Pyridoxine Hydrochloride

Doxylamine and pyridoxine is a combination antihistamine and vitamin B6 medication used to treat nausea and vomiting of pregnancy.

Generic name: Doxylamine Succinate, Pyridoxine Hydrochloride  ·  Brand names: Diclegis, Bonjesta.

See the full Doxylamine and Pyridoxine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Doxylamine Succinate, Pyridoxine Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Doxylamine Succinate, Pyridoxine Hydrochloride.

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Products that contain Doxylamine Succinate, Pyridoxine Hydrochloride-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Doxylamine Succinate, Pyridoxine Hydrochloride.

Calmhills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Migrahills by Herbal Hills contains Henbane Angiplex by UNDA Plex contains Belladonna Back & Neck Pain by BIOVEA Homeopathics contains Belladonna SuperFlex-H by NewtonEverett contains Belladonna CBD+13 by T-Relief contains Belladonna
Pharmacist Counseling Corner

Doxylamine Succinate, Pyridoxine Hydrochloride & Supplements: Common Questions

What supplements interact with Doxylamine Succinate, Pyridoxine Hydrochloride?
More than you might expect — 46 in total, though they are far from equal: 3 are rated major, 32 moderate, and 11 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Henbane, Scopolia.
Which Doxylamine Succinate, Pyridoxine Hydrochloride supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Henbane and Scopolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Doxylamine Succinate, Pyridoxine Hydrochloride?
Usually yes — most people on Doxylamine Succinate, Pyridoxine Hydrochloride can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Diclegis have the same supplement interactions as Doxylamine Succinate, Pyridoxine Hydrochloride?
Yes — Diclegis, Bonjesta all contain Doxylamine Succinate, Pyridoxine Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Doxylamine Succinate, Pyridoxine Hydrochloride and my other medications?
This page covers Doxylamine Succinate, Pyridoxine Hydrochloride against supplements and herbal ingredients. Checking Doxylamine Succinate, Pyridoxine Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Doxylamine and Pyridoxine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.