Drug & supplement interaction

Cubebs + Doxylamine Succinate, Pyridoxine Hydrochloride

Doxylamine Succinate, Pyridoxine Hydrochloride brand names: Diclegis, Bonjesta.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxylamine Succinate, Pyridoxine Hydrochloride states a food rule worth keeping to.

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Interaction report

Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxylamine Succinate, Pyridoxine Hydrochloride and Cubebs in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cubebs safety at a glance

Cubebs overall Use caution Likely fine in small culinary amounts, but safety of medicinal doses and the essential oil is not well studied.

Pregnancy Avoid Not enough safety information, so it is best avoided in medicinal amounts during pregnancy.

Breastfeeding Avoid No reliable safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxylamine Succinate, Pyridoxine Hydrochloride and Cubebs? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Doxylamine Succinate, Pyridoxine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxylamine Succinate, Pyridoxine Hydrochloride is filed under 2 classifications — anticholinergic drugs, oral drugs. Cubebs has documented interactions with 4 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), antacids (minor) and h2-blockers (minor) — and none of Doxylamine Succinate, Pyridoxine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cubebs Does Interact With Other Medications

Cubebs has 643 moderate, 22 minor known drug interactions in our database — Doxylamine Succinate, Pyridoxine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 Minor 22 No known interaction 2,165 (incl. Doxylamine Succinate, Pyridoxine Hydrochloride)

Taking anything else?

Check Another of Your Medications Against Cubebs

Covers the 2,830 medications we’ve checked against Cubebs. Pick one to open its full report.

What to actually watch for

What Doxylamine Succinate, Pyridoxine Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Cubebs. These are the most notable effects listed in the ADVERSE REACTIONS section of Doxylamine Succinate, Pyridoxine Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

Pain or burning when passing urine Worth acting on
Trouble passing urine Worth acting on
Confusion Worth acting on
Chest pain Worth acting on
Shortness of breath Worth acting on
An allergic reaction Worth acting on
Vivid dreams or nightmares
Migraine
Mood changes or irritability
Bloating or gas

Showing the 10 most notable of 27 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Doxylamine Succinate, Pyridoxine Hydrochloride. Read the label on DailyMed › Cubebs’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cubebs side to compare — that is a limit of the record, not a statement that Cubebs has no side effects.

How to take them

Some Doxylamine Succinate, Pyridoxine Hydrochloride Products Have a Food Rule — Cubebs Should Not Break It

At least one FDA label for a product containing Doxylamine Succinate, Pyridoxine Hydrochloride says to take it on an empty stomach. Most supplements — Cubebs included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxylamine Succinate, Pyridoxine Hydrochloride on its own and move Cubebs to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxylamine Succinate, Pyridoxine Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Take on an empty stomach with a glass of water [ see Clinical Pharmacology (12.3) ].

From the Dosage and Administration section of the FDA label we read for Doxylamine Succinate, Pyridoxine Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Doxylamine Succinate, Pyridoxine Hydrochloride

This page covers Cubebs only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxylamine Succinate, Pyridoxine Hydrochloride page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Doxylamine Succinate, Pyridoxine Hydrochloride page

“If you take doxylamine and pyridoxine (Diclegis, Bonjesta) for pregnancy nausea, this list deserves genuine care, because three of its 46 entries carry a major rating. The risk splits two ways.”

Reviewed by 2 · Jul 18, 2026

Open the Doxylamine Succinate, Pyridoxine Hydrochloride interaction page

One more smart check

Taking Cubebs as Part of a Dietary Supplement Product? Check It for Interactions

We hold 19 real supplement products containing Cubebs, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cubebs. Even though Cubebs itself has no known interaction with Doxylamine Succinate, Pyridoxine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cubebs

Top half

#543 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Doxylamine Succinate, Pyridoxine Hydrochloride

Steady interest

#2,586 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cubebs reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cubebs

What is Cubebs?

Coughs and bronchitis
Indigestion and gas
Urinary tract complaints
Sore throat
Culinary spice

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary problems. Modern human studies are very limited, so its benefits are not well proven. Use it cautiously as a food spice, and talk to your pharmacist or doctor before using concentrated extracts or oils.

Piper cubeba · Piperaceae · Dried unripe berries (fruit) and essential oil · Dried berries, powder, essential oil, tinctures, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Cubebs is a good idea for someone in your situation. Here is what our Cubebs record says about it on its own.

Cubebs: dosing

There is no well-established, standardized medicinal dose for cubebs. Traditional uses varied widely, and modern research has not defined a safe and effective amount.If you choose to use a cubeb product, follow the directions on the label and do not exceed the recommended amount. Essential oil should never be swallowed undiluted.

From our Cubebs monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cubebs monograph & all interactions

Medication

About Doxylamine and Pyridoxine

What Is Doxylamine and Pyridoxine Used For?

Brand names: Diclegis, Bonjesta

Doxylamine and pyridoxine is indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. This applies to the delayed-release tablets (including Diclegis and the generic doxylamine succinate and pyridoxine hydrochloride delayed-release tablets) as well as to Bonjesta, the extended-release tablet formulation.

None of these products have been studied in women with hyperemesis gravidarum (severe, persistent vomiting in pregnancy), so their use in that setting is not established.

See full Doxylamine and Pyridoxine drug information

Keep checking

Other Drugs & Cubebs

Browse every other medication we’ve checked against Cubebs — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

643Moderate

22Minor

2,164No known interaction

643 Moderate 22 Minor 2,164 No interaction

Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Cubebs page.

Minor

22 interactions

No interaction 2,164 drugs checked — show the list

We also checked Cubebs against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,164 medications checked with no known interaction — see the full Cubebs list.

See the full Cubebs interactions page

See every supplement checked against Doxylamine Succinate, Pyridoxine Hydrochloride, ranked by severity

Evidence & sources

Cubebs References

The 2 references that drive our Cubebs monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod 2005;68(1):64-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride Together: Common Questions

Is it safe to take Cubebs with Doxylamine Succinate, Pyridoxine Hydrochloride?

We do not list a known interaction between Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride at the same time of day?

At least one FDA label for a product containing Doxylamine Succinate, Pyridoxine Hydrochloride says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxylamine Succinate, Pyridoxine Hydrochloride on its own and move Cubebs to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Cubebs and Doxylamine Succinate, Pyridoxine Hydrochloride combination checked?

Interactions in our licensed database are recorded against drug classes. Doxylamine Succinate, Pyridoxine Hydrochloride is filed under 2 classifications, and Cubebs has documented interactions with 4 drug classes — none of Doxylamine Succinate, Pyridoxine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cubebs interact with any other medications?

Yes. Cubebs has 665 documented drug interactions in our database — Doxylamine Succinate, Pyridoxine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Doxylamine Succinate, Pyridoxine Hydrochloride interact with any supplements?

Yes. Doxylamine Succinate, Pyridoxine Hydrochloride has documented interactions with 46 supplements in our database — Cubebs is not one of them. The Doxylamine Succinate, Pyridoxine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cubebs monograph Uses, safety profile, and every drug interaction in one place Doxylamine and Pyridoxine drug information The full plain-English guide to this medication Doxylamine Succinate, Pyridoxine Hydrochloride supplement interactions Every supplement checked against Doxylamine Succinate, Pyridoxine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxylamine Succinate, Pyridoxine Hydrochloride and Cubebs?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.