Drug & supplement interaction

Forsythia + Doxylamine Succinate, Pyridoxine Hydrochloride

Doxylamine Succinate, Pyridoxine Hydrochloride brand names: Diclegis, Bonjesta.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxylamine Succinate, Pyridoxine Hydrochloride states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxylamine Succinate, Pyridoxine Hydrochloride and Forsythia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Forsythia safety at a glance

Forsythia overall Use caution Generally used short-term in traditional medicine, but human safety data are limited.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxylamine Succinate, Pyridoxine Hydrochloride and Forsythia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Doxylamine Succinate, Pyridoxine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxylamine Succinate, Pyridoxine Hydrochloride is filed under 2 classifications — anticholinergic drugs, oral drugs. Forsythia has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and azithromycin (zithromax) (minor) — and none of Doxylamine Succinate, Pyridoxine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Forsythia Does Interact With Other Medications

Forsythia has 122 moderate, 1 minor known drug interactions in our database — Doxylamine Succinate, Pyridoxine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 Minor 1 No known interaction 2,707 (incl. Doxylamine Succinate, Pyridoxine Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Forsythia

Covers the 2,830 medications we’ve checked against Forsythia. Pick one to open its full report.

What to actually watch for

What Doxylamine Succinate, Pyridoxine Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Forsythia. These are the most notable effects listed in the ADVERSE REACTIONS section of Doxylamine Succinate, Pyridoxine Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Trouble passing urine Worth acting on
  • Confusion Worth acting on
  • Chest pain Worth acting on
  • Shortness of breath Worth acting on
  • An allergic reaction Worth acting on
  • Vivid dreams or nightmares
  • Migraine
  • Mood changes or irritability
  • Bloating or gas

Showing the 10 most notable of 27 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Doxylamine Succinate, Pyridoxine Hydrochloride. Read the label on DailyMed › Forsythia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Forsythia side to compare — that is a limit of the record, not a statement that Forsythia has no side effects.

How to take them

Some Doxylamine Succinate, Pyridoxine Hydrochloride Products Have a Food Rule — Forsythia Should Not Break It

At least one FDA label for a product containing Doxylamine Succinate, Pyridoxine Hydrochloride says to take it on an empty stomach. Most supplements — Forsythia included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxylamine Succinate, Pyridoxine Hydrochloride on its own and move Forsythia to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxylamine Succinate, Pyridoxine Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Take on an empty stomach with a glass of water [ see Clinical Pharmacology (12.3) ].

From the Dosage and Administration section of the FDA label we read for Doxylamine Succinate, Pyridoxine Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Doxylamine Succinate, Pyridoxine Hydrochloride

This page covers Forsythia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxylamine Succinate, Pyridoxine Hydrochloride page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Doxylamine Succinate, Pyridoxine Hydrochloride page

“If you take doxylamine and pyridoxine (Diclegis, Bonjesta) for pregnancy nausea, this list deserves genuine care, because three of its 46 entries carry a major rating. The risk splits two ways.”

Reviewed by 2 · Jul 18, 2026

Open the Doxylamine Succinate, Pyridoxine Hydrochloride interaction page

One more smart check

Taking Forsythia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 355 real supplement products containing Forsythia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Forsythia. Even though Forsythia itself has no known interaction with Doxylamine Succinate, Pyridoxine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Forsythia
Top 25%

#325 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxylamine Succinate, Pyridoxine Hydrochloride
Top 25%

#325 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Forsythia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Forsythia

What is Forsythia?

  • Colds and flu symptoms
  • Sore throat
  • Fever
  • Inflammation
  • Antimicrobial support

Forsythia is a traditional Chinese herb, used mainly for cold and flu symptoms and as part of multi-herb formulas. Most evidence comes from laboratory, animal, and traditional use rather than strong human studies, so its real-world benefits remain unproven. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Forsythia suspensa · Oleaceae · Dried fruit (and sometimes leaves) · Dried fruit, teas, decoctions, capsules, and herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Forsythia is a good idea for someone in your situation. Here is what our Forsythia record says about it on its own.

Forsythia: dosing

There is no well-established standardized dose for forsythia. Traditional preparations use the dried fruit in decoctions, often as part of a multi-herb formula, and amounts vary by product and practitioner.If you use a commercial supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Forsythia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Forsythia monograph & all interactions
Medication

About Doxylamine and Pyridoxine

What Is Doxylamine and Pyridoxine Used For?

Brand names: Diclegis, Bonjesta

Doxylamine and pyridoxine treats nausea and vomiting of pregnancy in women who do not respond to conservative management. Diclegis, Bonjesta and generic doxylamine succinate and pyridoxine hydrochloride delayed-release tablets are all labeled for this use.

None of these products has been studied in women with hyperemesis gravidarum (severe, persistent vomiting in pregnancy).

See full Doxylamine and Pyridoxine drug information
Keep checking

Other Drugs & Forsythia

Browse every other medication we’ve checked against Forsythia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
1Minor
2,706No known interaction
122 Moderate 1 Minor 2,706 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Forsythia page.

Minor

1 interaction

No interaction 2,706 drugs checked — show the list

We also checked Forsythia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,706 medications checked with no known interaction — see the full Forsythia list.

See the full Forsythia interactions page
See every supplement checked against Doxylamine Succinate, Pyridoxine Hydrochloride, ranked by severity
Evidence & sources

Forsythia References

The 3 references that drive our Forsythia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kong XT, Fang HT, Jiang GQ, et al. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis Child 1993;68:468-71. PubMed
  2. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  3. Li XG, Ni J, Shen S, Wang XP, Tian JC. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats. Chin J Nat Med 2020;18(3):234-240. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride Together: Common Questions

Is it safe to take Forsythia with Doxylamine Succinate, Pyridoxine Hydrochloride?
We do not list a known interaction between Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride at the same time of day?
At least one FDA label for a product containing Doxylamine Succinate, Pyridoxine Hydrochloride says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxylamine Succinate, Pyridoxine Hydrochloride on its own and move Forsythia to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Forsythia and Doxylamine Succinate, Pyridoxine Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Doxylamine Succinate, Pyridoxine Hydrochloride is filed under 2 classifications, and Forsythia has documented interactions with 2 drug classes — none of Doxylamine Succinate, Pyridoxine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Forsythia interact with any other medications?
Yes. Forsythia has 123 documented drug interactions in our database — Doxylamine Succinate, Pyridoxine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Doxylamine Succinate, Pyridoxine Hydrochloride interact with any supplements?
Yes. Doxylamine Succinate, Pyridoxine Hydrochloride has documented interactions with 46 supplements in our database — Forsythia is not one of them. The Doxylamine Succinate, Pyridoxine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Forsythia monograph Uses, safety profile, and every drug interaction in one place Doxylamine and Pyridoxine drug information The full plain-English guide to this medication Doxylamine Succinate, Pyridoxine Hydrochloride supplement interactions Every supplement checked against Doxylamine Succinate, Pyridoxine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxylamine Succinate, Pyridoxine Hydrochloride and Forsythia?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.