Drug & supplement interaction

Glucomannan + Diclofenac epolamine

Diclofenac epolamine brand names: Flector, Licart.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Glucomannan and Diclofenac epolamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Glucomannan and Diclofenac epolamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac epolamine and Glucomannan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Glucomannan safety at a glance

Glucomannan overall Use caution Generally well tolerated when taken with plenty of water, but it can cause choking or blockage if not swallowed properly.
Pregnancy Use caution Not enough reliable safety data; talk to your doctor before using during pregnancy.
Breastfeeding Use caution Little is known about its safety while breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac epolamine and Glucomannan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diclofenac epolamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diclofenac epolamine is filed under 10 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Glucomannan has documented interactions with 1 drug class — the most serious being oral drugs (moderate) — and none of Diclofenac epolamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Glucomannan Does Interact With Other Medications

Glucomannan has 2,022 moderate known drug interactions in our database — Diclofenac epolamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2,022 No known interaction 808 (incl. Diclofenac epolamine)
Taking anything else?

Check Another of Your Medications Against Glucomannan

Covers the 2,830 medications we’ve checked against Glucomannan. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Glucomannan and Diclofenac epolamine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Glucomannan

    “Acute cholestatic hepatitis occurred in a 31-year-old male after taking glucomannan orally for 45 days. He was also taking other supplements, including garlic and chitosan, so it is unclear whether the hepatitis was due to glucomannan, other supplements, or the combination.”

    Glucomannan · Natural Medicines adverse-effect record, reported in hepatitis.

    1 source cited
    1. 57777. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed

    Diclofenac epolamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac epolamine. Read the label on DailyMed ›

  • Nausea reported in 5.2% of FDA reports for Diclofenac epolamine Additional detail

    Glucomannan

    “Orally, glucomannan can cause gastrointestinal disturbances, including abdominal pain, bloating, constipation, diarrhea, flatulence, nausea, and vomiting, especially when taken in doses of more than 3 grams daily. Esophageal and gastrointestinal obstructions have been reported when dry glucomannan-containing products are taken with insufficient fluid.”

    Glucomannan · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 57781. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
    2. 57784. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
    3. 92004. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
    4. 92010. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
    5. 92011. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
    6. 97935. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.

    Diclofenac epolamine

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac epolamine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Glucomannan but not commonly for Diclofenac epolamine: stomach upset, stomach pain, constipation and bloating or gas.

Effects for Diclofenac epolamine come from the ADVERSE REACTIONS section of its FDA label; effects for Glucomannan come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 4,258 voluntary FDA FAERS reports for Diclofenac epolamine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Diclofenac epolamine

This page covers Glucomannan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac epolamine page lists 292 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Beer (major), Danshen (major), Piracetam (major) and Siberian Cocklebur (major).

By severity: 6 major · 259 moderate · 27 minor.

From our pharmacist’s overview on the Diclofenac epolamine page

“Even as a patch, diclofenac epolamine (Flector, Licart) is still an NSAID that reaches the bloodstream, and its 292 supplement interactions call for genuine care, six of them rated major. The bulk of the list, 202 ingredients, thins the blood or slows clotting, which stacks onto an NSAID's built-in bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac epolamine interaction page

One more smart check

Taking Glucomannan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 467 real supplement products containing Glucomannan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Glucomannan. Even though Glucomannan itself has no known interaction with Diclofenac epolamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Glucomannan and Diclofenac epolamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Glucomannan
Top 25%

#223 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac epolamine
Top half

#776 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Glucomannan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Glucomannan and Diclofenac epolamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Glucomannan

What is Glucomannan?

Glucomannan
  • Weight loss and appetite control
  • Constipation
  • High cholesterol
  • Blood sugar support
  • Digestive health

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is generally well tolerated when taken with plenty of water, but it must be taken carefully because it can swell and cause choking or blockage if not swallowed properly. Talk with your pharmacist or doctor before starting it, especially if you have a health condition or take medicines.

Amorphophallus konjac · Araceae · Root (tuber/corm) · Capsules, tablets, powder, drink mixes; also used as a food ingredient (konjac noodles, shirataki noodles)

An interaction check asks whether these two react with each other — it does not ask whether Glucomannan is a good idea for someone in your situation. Here is what our Glucomannan record says about it on its own.

Glucomannan: dosing

There is no single official standardized dose of glucomannan, and the right amount can vary by product and purpose. Because it is a concentrated fiber, the way you take it matters as much as the amount.The best advice is to follow the directions on the product label and to take each dose with a full glass of water (and drink fluids throughout the day).

From our Glucomannan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Glucomannan monograph & all interactions
Medication

About Diclofenac epolamine

Most-Reported Side Effects for Diclofenac epolamine

From FAERS, the FDA’s public side-effect reporting system (4,258 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 236 reports
Nausea 220 reports
Headache 176 reports
Dizziness 163 reports
Rash 159 reports
Keep checking

Other Drugs & Glucomannan

Browse every other medication we’ve checked against Glucomannan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2,022Moderate
0Minor
807No known interaction
2,022 Moderate 807 No interaction
Moderate

2,022 interactions

Showing 60 of 2,022 moderate interactions — see all 2,022 on the Glucomannan page.

No interaction 807 drugs checked — show the list

We also checked Glucomannan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 807 medications checked with no known interaction — see the full Glucomannan list.

See the full Glucomannan interactions page
See every supplement checked against Diclofenac epolamine, ranked by severity
Evidence & sources

Glucomannan References

The 15 references that drive our Glucomannan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Glucomannan and Diclofenac epolamine Together: Common Questions

Is it safe to take Glucomannan with Diclofenac epolamine?
We do not list a known interaction between Glucomannan and Diclofenac epolamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Glucomannan and Diclofenac epolamine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Glucomannan and Diclofenac epolamine combination checked?
Interactions in our licensed database are recorded against drug classes. Diclofenac epolamine is filed under 10 classifications, and Glucomannan has documented interactions with 1 drug class — none of Diclofenac epolamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Glucomannan interact with any other medications?
Yes. Glucomannan has 2,022 documented drug interactions in our database — Diclofenac epolamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diclofenac epolamine interact with any supplements?
Yes. Diclofenac epolamine has documented interactions with 292 supplements in our database — Glucomannan is not one of them. The Diclofenac epolamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Glucomannan monograph Uses, safety profile, and every drug interaction in one place Diclofenac epolamine supplement interactions Every supplement checked against Diclofenac epolamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac epolamine and Glucomannan?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.